E67-2
E67-2, as the E67 derivative, is a low-toxicity, selective KIAA1718 Jumonji domain inhibitor with an IC50 value of 3.4 µM. E67-2 selectively inhibits histone H3 lysine 9 (H3K9) Jumonji demethylase as well as histone H3 lysine 4 (H3K4) demethylase.
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- CAS 番号: 1364914-62-4
- 分子式: C21H36N6O2
- 分子量:404.55
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
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Help & FAQs
Histone Methyltransferase アイソフォーム固有の製品をすべて表示
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生物活性
IC50: 3.4 μM (H3K9 Jumonji demethylase)[1]
E67-2 (1~100 μM; 5 minutes) reduces inhibitory effect against GLP by a factor of approximately 1500, resulting in an IC50 of 75 µM. E67-2 has much reduced inhibition on PHF8 on the doubly methylated H3(1-24)K4me3K9me2 peptide substrate. E67-2 (100~100000 nM; 24 hours; fibroblasts) has significantly reduced cell toxicity [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1364914-62-4
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分子量 404.55
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分子式 C21H36N6O2
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SMILES
CN(C)C1=C2C=C(OC)C(OCCCCCN)=CC2=NC(NCCCN(C)C)=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (264 KB)
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SDS (252 KB)
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- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
E67-2 関連分類
HY-122746 関連分類
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