EA-Ri-153
EA-Ri-153 is a selective D3R agonist. EA-Ri-153 has a Ki = 2.8 nM and pEC50 = 8.9 for D3R, and a Ki = 1.2 μM for D2R, with a D3/D2 selectivity ratio of 435-fold. EA-Ri-153 has a Ki = 2.5 μM for 5-HT1AR and a Ki = 22.8 μM for 5-HT2AR. EA-Ri-153 can be used for research on diseases related to the dopamine D3 receptor subtype.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C22H36FN3O4S
- 分子量:457.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
D3 Receptor 2.8 nM (Ki) |
D3 Receptor 8.9 (pEC50) |
D2 Receptor 1.2 nM (Ki) |
体外実験
EA-Ri-153 is a potent agonist of WT D3R in HEK293 cells, with a pEC50 of 8.9 and an Emax of 107% in the GαoA BRET GPA assay[1].
EA-Ri-153 has a Ki = 2.5 μM for 5‑HT1AR and a Ki = 22.8 μM for 5‑HT2AR[1].
EA-Ri-153 shows a logPe of -4.53 in BBB-PAMPA, with a predicted logBB of 0.76[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 457.60
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分子式 C22H36FN3O4S
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SMILES
O=S(CCOC)(N[C@H]1CC[C@H](CCN2CCN(C3=CC=CC(OC)=C3F)CC2)CC1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
EA-Ri-153 関連分類
HY-189719 関連分類
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