製品番号: HY-N2086

パルミチン酸エチル

(別名: Ethyl palmitate; Ethyl hexadecanoate)

2 Cited Publications

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Ethyl palmitate (Ethyl hexadecanoate) is a CHIKV virus inhibitor with an EC₅₀ value of 0.0068 μM. Ethyl palmitate can reduce levels of TNF-α, IL-6, and NF-κB in endotoxemic rats, showing anti-inflammatory activity.

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純度: 99.09%
CAS 番号: 628-97-7
分子式: C₁₈H₃₆O₂
分子量:284.48

保管条件:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Ethyl palmitate 構造式

CAS 番号: 628-97-7

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Amount: USD 0.00

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製品説明

NF-κB アイソフォーム固有の製品をすべて表示 :

Interleukin Related アイソフォーム固有の製品をすべて表示 :

TNF Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

Ethyl palmitate (1 μg/mL; 24, 48 h) can inhibit the expression and viral activity of CHIKV virus E2 protein, with an EC₅₀ value of 0.0068 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2].

Cell Line:

CHIKV infected Vero cells
Concentration:

1 μg/mL
Incubation Time:

24, 48 h
Result:

Resulted in no expression of CHIKV E2 protein.

体内実験

Ethyl palmate (10 mL/kg; once; i.p.) can reduce the levels of TNF-α, IL-6, and NF-κB in endotoxemia rats, improve the histopathological changes induced by LPS, and has anti-inflammatory activity^[1].
Ethyl palmate (1.5 mg/kg; once daily; 3 weeks; i.v.) can inhibit the phagocytic function of the reticuloendothelial system (RES) in dogs and reduce liver blood flow^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

A rat model of lipopolysaccharide (LPS)-induced endotoxemia^[1].
Dosage:

10 mL/kg
Administration:

Intraperitoneal injection (i.p.); once
Result:

Reduced plasma levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), decreased NF-κB expression in liver and lung tissues and ameliorated histopathological changes caused by LPS.

Animal Model:

12 dogs of both sexes, weighing between 5.0 and 11.2 kg^[3].
Dosage:

1.5 mg/kg
Administration:

Intravenous injection (i.v.); once daily; 3 weeks
Result:

Inhibited the phagocytic activity of red blood cells and led to hepatocyte degeneration and local necrosis.

化学情報

CAS 番号 628-97-7
性状 <24°C Solid,>26°C Liquid
分子量 284.48
分子式 C₁₈H₃₆O₂
Color Colorless to light yellow
SMILES

CCCCCCCCCCCCCCCC(OCC)=O
別名

Ethyl palmitate; Ethyl hexadecanoate
Structure Classification
- Lipids
Initial Source
- Plants
- Umbelliferae
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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PLoS Biol

A high-throughput behavioral screening platform for measuring chemotaxis by C. elegans. [Abstract]

2024 Jun 27;22(6):e3002672. PMID: 38935621
bioRxiv

An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in C. elegans. [Abstract]

2024 Apr 3:2023.06.02.542933. PMID: 37333363

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (351.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.5152 mL

17.5759 mL

35.1519 mL

5 mM

0.7030 mL

3.5152 mL

7.0304 mL

10 mM

0.3515 mL

1.7576 mL

3.5152 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (8.79 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (8.79 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (8.79 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

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COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
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参考文献

[1]. Saeed NM, et al. Anti-inflammatory activity of methyl palmitate and ethyl palmitate in different experimental rat models. Toxicol Appl Pharmacol. 2012 Oct 1;264(1):84-93. [Content Brief]

[2]. Sagna A, et al. Ethyl palmitate, an anti-chikungunya virus principle from Sauropus androgynus, a medicinal plant used to alleviate fever in ethnomedicine. J Ethnopharmacol. 2023 Jun 12;309:116366. [Content Brief]

[3]. Areekul S, et al. Studies on liver blood flow and phagocytic activity of reticuloendothelial system in dogs treated with ethyl palmitate. Southeast Asian J Trop Med Public Health. 1973 Sep;4(3):395-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.5152 mL	17.5759 mL	35.1519 mL	87.8796 mL
	5 mM	0.7030 mL	3.5152 mL	7.0304 mL	17.5759 mL
	10 mM	0.3515 mL	1.7576 mL	3.5152 mL	8.7880 mL
	15 mM	0.2343 mL	1.1717 mL	2.3435 mL	5.8586 mL
	20 mM	0.1758 mL	0.8788 mL	1.7576 mL	4.3940 mL
	25 mM	0.1406 mL	0.7030 mL	1.4061 mL	3.5152 mL
	30 mM	0.1172 mL	0.5859 mL	1.1717 mL	2.9293 mL
	40 mM	0.0879 mL	0.4394 mL	0.8788 mL	2.1970 mL
	50 mM	0.0703 mL	0.3515 mL	0.7030 mL	1.7576 mL
	60 mM	0.0586 mL	0.2929 mL	0.5859 mL	1.4647 mL
	80 mM	0.0439 mL	0.2197 mL	0.4394 mL	1.0985 mL
	100 mM	0.0352 mL	0.1758 mL	0.3515 mL	0.8788 mL

Keywords

Ethyl palmitate

2 Cited Publications

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MedChemExpress（MCE）の使用を引用している文献 Ethyl palmitate

NF-κB アイソフォーム固有の製品をすべて表示

Interleukin Related アイソフォーム固有の製品をすべて表示

TNF Receptor アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (2)

溶剤 & 溶解度