Hardwickiic acid
Based on 1 publication(s) in Google Scholar
Hardwickiic acid ((-)-Hardwickiic acid) is a diterpenoid compound. Hardwickiic acid can block tetrodotoxin-sensitive voltage-dependent sodium channels and possesses multiple activities such as insecticidal, antinociceptive, and neurotransmitter release-regulating effects. Hardwickiic acid can be used in the study of neurological diseases.
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- 純度: 99.91%
- CAS 番号: 1782-65-6
- 分子式: C20H28O3
- 分子量:316.43
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Hardwickiic acid
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生物活性
Hardwickiic acid (0-100 nM; 90 s) promotes K+-evoked [3H]noradrenaline overflow in mouse hippocampal synaptosomes[1].
Hardwickiic acid (5 ppm; 24 h) causes 62% mortality in adult female Aphis craccivora aphids[2].
Hardwickiic acid (20 μM) inhibits tetrodotoxin-sensitive voltage-gated sodium channels in rat dorsal root ganglion neurons[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Sprague-Dawley rats (225-250 g) treated HIV-1 gp120 or Paclitaxel (HY-B0015)[3]
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Dosage:2 μg/5 μL
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Administration:Intrathecal injection; single dose
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Result:Significantly reversed mechanical allodynia 1-2 h post-injection, with the effect lasting for 2-3 additional hours in HIV-1 gp120-induced sensory neuropathy model.
Significantly relieved mechanical allodynia 0.5 h post-injection, with the effect lasting for 2-3 hours in paclitaxel-induced peripheral neuropathy model.
化学情報
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CAS 番号 1782-65-6
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性状 Solid
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分子量 316.43
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分子式 C20H28O3
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Color White to off-white
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SMILES
C[C@]12[C@@](CCC=C2C(O)=O)([H])[C@](C)([C@H](C)CC1)CCC3=COC=C3
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別名
(-)-Hardwickiic acid; (-)-Hardwikiic acid
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Structure Classification
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
2023 Jun 3;14(1):3224. PMID: 37270609
純度とドキュメンテーション
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データシート (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Pittaluga A, et al. Effects of the neoclerodane Hardwickiic acid on the presynaptic opioid receptors which modulate noradrenaline and dopamine release in mouse central nervous system. Neurochem Int. 2013 Mar;62(4):354-9. [Content Brief]
[2]. Bandara BM, et al. Isolation and Insecticidal Activity of (-)-Hardwickiic Acid from Croton aromaticus. Planta Med. 1987 Dec;53(6):575. [Content Brief]
[3]. Cai S, et al. (-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 Mar 20;10(3):1716-1728. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Hardwickiic acid 関連分類
HY-N3990 関連分類
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