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製品番号: HY-W707749

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Isomalathion

Isomalathion is an isomer and impurity of Malathion (HY-B0943). Isomalathion inhibits Carboxyesterase and AChE, with an IC₅₀ value of 3.2 μM against bovine acetylcholinesterase. Isomalathion moderately reduces CYP1A2 transcript levels, increases CYP2B6 transcript levels, and induces dose-dependent DNA damage. Malathion is an organophosphorus insecticide.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3344-12-5
分子式: C₁₀H₁₉O₆PS₂
分子量:330.36

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Isomalathion 構造式

CAS 番号: 3344-12-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[2]^[1]

AChE

3.2 μM (IC₅₀)

CYP1A2

CYP2B6

Cholinesterase (ChE) アイソフォーム固有の製品をすべて表示 :

AChE
BChE

Cytochrome P450 アイソフォーム固有の製品をすべて表示 :

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

体外実験

ApoptosisOxidative StressOthers

Apoptosis

Isomalathion (0.05-50 μM; 24 h) induces dose-dependent activation of caspase-3 in differentiated HepaRG cells, and this effect is triggered at a concentration of 5 μM after 24 h of exposure^[1].

Oxidative Stress

Isomalathion (0.05-50 μM; 24 h) induces mild reactive oxygen species (ROS) production in differentiated HepaRG cells at the concentration of 50 μM following 24 h of exposure^[1].
Isomalathion (0.05-50 μM; 24 h) increases HO-1 mRNA expression levels by twofold in differentiated HepaRG cells. This effect occurs after 24 h of exposure at a concentration of 25 μM, but has no impact on the expression of Nrf2 or MnSOD^[1].

Others

Isomalathion (100-500 μM; 24 h) reduces the viability of differentiated HepaRG cells starting at a concentration of 100 μM with a 24 h exposure^[1].
Isomalathion potently inhibits free bovine erythrocyte acetylcholinesterase (AChE), with an IC₅₀ of 3.2 μM for its irreversible inhibitory effect^[2].
Isomalathion potently inhibits immobilized bovine erythrocyte acetylcholinesterase (AChE), with an IC₅₀ of 2.7 μM, and immobilization does not alter the sensitivity of this enzyme to Isomalathion^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

differentiated human HepaRG cells
Concentration:

100-500 μM
Incubation Time:

24 h
Result:

Reduced HepaRG cell viability starting at 100 μM, with further decreases observed at 200 μM and 500 μM.
Restricted morphological alterations to hepatocyte-like cells within the culture.

Real Time qPCR^[1]

Cell Line:

differentiated human HepaRG cells
Concentration:

0.05-50 μM
Incubation Time:

24 h
Result:

Increased HO-1 mRNA expression in HepaRG cells by two-fold at 25 μM.
Observed no significant effects on Nrf2 or MnSOD mRNA levels at any tested concentration.\n
Decreased CYP1A2 mRNA levels and increased CYP2B6 mRNA levels in HepaRG cells at concentrations from 5 μM up to 50 μM.
Observed no significant effect on CYP3A4 mRNA levels.

Related Protocols :

Genotoxicity/Mutagenicity Study

化学情報

CAS 番号 3344-12-5
分子量 330.36
分子式 C₁₀H₁₉O₆PS₂
SMILES

O=C(CC(C(OCC)=O)SP(OC)(SC)=O)OCC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Josse R, et al. Impact of isomalathion on malathion cytotoxicity and genotoxicity in human HepaRG cells. Chemico-biological interactions. 2014 Feb 25;209:68-76.

[2]. Krstić DZ, et al. Inhibition of AChE by malathion and some structurally similar compounds. Journal of enzyme inhibition and medicinal chemistry. 2008 Aug;23(4):562-73.

[3]. Błasiak J, et al. In vitro studies on the genotoxicity of the organophosphorus insecticide malathion and its two analogues. Mutation research. 1999 Sep 30;445(2):275-83.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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製品番号:
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Isomalathion

Cholinesterase (ChE) アイソフォーム固有の製品をすべて表示

Cytochrome P450 アイソフォーム固有の製品をすべて表示

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Isomalathion 関連分類

HY-W707749 関連分類

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