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製品番号: HY-126211

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KBH-A42

KBH-A42 is a novel histone deacetylase (HDAC) inhibitor with significant anti-inflammatory properties. KBH-A42 against TNF-α and NO production with IC₅₀ values of 1.10 and 2.71 µM, respectively, in the LPS-induced murine macrophage RAW 264.7 cells.

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CAS 番号: 798543-50-7
分子式: C₁₇H₂₂N₂O₃
分子量:302.37

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

KBH-A42 構造式

CAS 番号: 798543-50-7

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

HDAC アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
ACHN	GI₅₀	1.17 μM Compound: 14c	Growth inhibition of ACHN cells by SRB assay Growth inhibition of ACHN cells by SRB assay	[PMID: 17477518]
ACHN	GI₅₀	1.17 μM Compound: 4h	Cytotoxicity against human ACHN cells Cytotoxicity against human ACHN cells	[PMID: 21256006]
HCT-15	GI₅₀	4.99 μM Compound: 14c	Growth inhibition of HCT15 cells by SRB assay Growth inhibition of HCT15 cells by SRB assay	[PMID: 17477518]
HCT-15	GI₅₀	4.99 μM Compound: 4h	Cytotoxicity against human HCT15 cells Cytotoxicity against human HCT15 cells	[PMID: 21256006]
HeLa	IC₅₀	0.27 μM Compound: 14c	Inhibition of HDAC in HeLa cells by fluorescent activity assay Inhibition of HDAC in HeLa cells by fluorescent activity assay	[PMID: 17477518]
LOX IMVI	GI₅₀	3.34 μM Compound: 14c	Growth inhibition of LOX-IMVI cells by SRB assay Growth inhibition of LOX-IMVI cells by SRB assay	[PMID: 17477518]
LOX IMVI	GI₅₀	3.34 μM Compound: 4h	Cytotoxicity against human LOXIMVI cells Cytotoxicity against human LOXIMVI cells	[PMID: 21256006]
MDA-MB-231	GI₅₀	0.5 μM Compound: 14c	Growth inhibition of human MDA-MB-231 cells by SRB assay Growth inhibition of human MDA-MB-231 cells by SRB assay	[PMID: 17477518]
MDA-MB-231	GI₅₀	0.5 μM Compound: 4h	Cytotoxicity against human MDA-MB-231 cells Cytotoxicity against human MDA-MB-231 cells	[PMID: 21256006]
NCI-H23	GI₅₀	3.79 μM Compound: 14c	Growth inhibition of NCI-H23 cells by SRB assay Growth inhibition of NCI-H23 cells by SRB assay	[PMID: 17477518]
NCI-H23	GI₅₀	3.79 μM Compound: 4h	Cytotoxicity against human NCI-H23 cells Cytotoxicity against human NCI-H23 cells	[PMID: 21256006]
PC-3	GI₅₀	5.04 μM Compound: 14c	Growth inhibition of PC3 cells by SRB assay Growth inhibition of PC3 cells by SRB assay	[PMID: 17477518]
PC-3	GI₅₀	6.98 μM Compound: 4h	Cytotoxicity against human PC3 cells Cytotoxicity against human PC3 cells	[PMID: 21256006]
RAW264.7	IC₅₀	1.1 μM Compound: 14c	Inhibition of LPS-stimulated TNFalpha production in RAW264.7 cells after 24 hrs by ELISA Inhibition of LPS-stimulated TNFalpha production in RAW264.7 cells after 24 hrs by ELISA	[PMID: 17477518]
RAW264.7	IC₅₀	2.71 μM Compound: 14c	Inhibition of LPS-stimulated NO production in RAW264.7 cells after 24 hrs by ELISA Inhibition of LPS-stimulated NO production in RAW264.7 cells after 24 hrs by ELISA	[PMID: 17477518]

化学情報

CAS 番号 798543-50-7
分子量 302.37
分子式 C₁₇H₂₂N₂O₃
SMILES

O=C(CCC1=CCCN(C1=O)CCCC2=CC=CC=C2)NO
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (264 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Yongseok Choi, et al. Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model. Experimental & Molecular Medicine. 2008, 40, 574-581.

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How should lyophilized recombinant proteins be reconstituted and stored?

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100 mg

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