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製品番号: HY-186272

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MS8847N2

MS8847N2 is a negative control analog of an EZH2 PROTAC degrader that binds EZH2 but does not bind the VHL E3 ligase or induce EZH2 degradation.

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CAS 番号: 3050872-64-2
分子式: C₇₀H₉₈N₁₀O₈S
分子量:1239.65

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

MS8847N2 構造式

CAS 番号: 3050872-64-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

MS8847N2 is a negative control analog of an EZH2 PROTAC degrader that binds EZH2 but does not bind the VHL E3 ligase or induce EZH2 degradation^[1].

体外実験

MS8847N2 (0.03-0.3 μM; 24 h) does not degrade EZH2 or reduce H3K27me3 levels in EOL-1 MLL-rearranged acute myeloid leukemia cells after 24 h treatment at concentrations up to 0.3 μM^[1].
MS8847N2 (0.03-0.3 μM; 24 h) does not degrade EZH2 in MV4;11 MLL-rearranged acute myeloid leukemia cells after 24 h treatment at concentrations up to 0.3 μM, with only minimal reduction of H3K27me3 levels^[1].
MS8847N2 (5 days) does not inhibit cell growth in MV4;11 MLL-rearranged acute myeloid leukemia cells after 5 days of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

EOL-1 MLL-rearranged acute myeloid leukemia cells
Concentration:

0.03, 0.1, 0.3 μM
Incubation Time:

24 h
Result:

Showed no degradation of EZH2 protein at any tested concentration.
Showed no reduction of H3K27me3 protein levels compared to DMSO control.

Western Blot Analysis^[1]

Cell Line:

MV4;11 MLL-rearranged acute myeloid leukemia cells
Concentration:

0.03, 0.1, 0.3 μM
Incubation Time:

24 h
Result:

Showed no degradation of EZH2 protein at any tested concentration.
Showed only minimal reduction of H3K27me3 protein levels compared to DMSO control.

化学情報

CAS 番号 3050872-64-2
分子量 1239.65
分子式 C₇₀H₉₈N₁₀O₈S
SMILES

CCN(C1CCOCC1)C2=CC(C3=CC=C(C=C3)CN4CCN(CC4)CCC(NCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@H](C[C@@H](C5)O)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O)=O)=CC(C(NCC8=C(C=C(NC8=O)C)C)=O)=C2C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Velez J, et al. Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2. European journal of medicinal chemistry. 2024 Mar 05;267:116154. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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