NPD-001
Based on 1 Customer Validation
NPD-001 is a potent Trypanosoma brucei phosphodiesterases 1/2 (TbrPDEB1/2) inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits hPDE4. NPD-001 can increase cAMP levels in parasites, prevent cytokinesis, and cause the parasites to form multinucleated, multi-flagellated cells that eventually lyse. NPD-001 can be used for the research of infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.11%
- CAS 番号: 469863-16-9
- 分子式: C33H40N6O4
- 分子量:584.72
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Trypanosoma |
PDE1 4 nM (IC50) |
PDE2 3 nM (IC50) |
hPDE4D |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
>25 μM
Compound: 15; MMV690027
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by resazurin dye based fluorescence assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by resazurin dye based fluorescence assay
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[PMID: 30647879] |
| Sf21 | IC50 |
0.004 μM
Compound: 3, PPS54019
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Inhibition of Trypanosoma brucei full length PDEB1 expressed in insect SF21 cells using cAMP as substrate by scintillation proximity assay
Inhibition of Trypanosoma brucei full length PDEB1 expressed in insect SF21 cells using cAMP as substrate by scintillation proximity assay
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[PMID: 23409953] |
NPD-001 inhibits the proliferation of Trypanosoma brucei bloodstream form trypomastigotes, with -log EC50 of 7.7[1].
NPD-001 shows low cytotoxicity against human MRC-5 fibroblasts, with a selectivity index (MRC-5 cells/T. b. brucei) of 316[1].
NPD-001 potently inhibits human PDE4 subtypes (pIC50 = 9.2 for hPDE4B1, 9.3 for hPDE4B2, 9.2 for hPDE4D3)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 469863-16-9
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性状 Solid
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分子量 584.72
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分子式 C33H40N6O4
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Color Off-white to light yellow
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SMILES
O=C1N(C2CCCCCC2)N=C(C3=CC=C(OC)C(OCCCCOC4=CC=C(C5=NN=NN5)C=C4)=C3)[C@@]6([H])CC=CC[C@@]16[H]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (171.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7102 mL | 8.5511 mL | 17.1022 mL | 42.7555 mL |
| 5 mM | 0.3420 mL | 1.7102 mL | 3.4204 mL | 8.5511 mL | |
| 10 mM | 0.1710 mL | 0.8551 mL | 1.7102 mL | 4.2756 mL | |
| 15 mM | 0.1140 mL | 0.5701 mL | 1.1401 mL | 2.8504 mL | |
| 20 mM | 0.0855 mL | 0.4276 mL | 0.8551 mL | 2.1378 mL | |
| 25 mM | 0.0684 mL | 0.3420 mL | 0.6841 mL | 1.7102 mL | |
| 30 mM | 0.0570 mL | 0.2850 mL | 0.5701 mL | 1.4252 mL | |
| 40 mM | 0.0428 mL | 0.2138 mL | 0.4276 mL | 1.0689 mL | |
| 50 mM | 0.0342 mL | 0.1710 mL | 0.3420 mL | 0.8551 mL | |
| 60 mM | 0.0285 mL | 0.1425 mL | 0.2850 mL | 0.7126 mL | |
| 80 mM | 0.0214 mL | 0.1069 mL | 0.2138 mL | 0.5344 mL | |
| 100 mM | 0.0171 mL | 0.0855 mL | 0.1710 mL | 0.4276 mL |
NPD-001 関連分類
HY-136637 関連分類
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