NT376
NT376 is a high potency and selectivity inhibitor of class-IIa Histone deacetylases (HDAC) with an IC50 value of 32 nM, similar to NT160 (HY-149285) (IC50= 46 nM) in HT-29 cells. NT376 is proming for research of various cancers and in the diseases of the central nervous system (CNS) such as Alzheimer’s and Huntington’s diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2820208-97-5
- 分子式: C21H20F4N4O2
- 分子量:436.40
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
HDAC4 1.26 nM (IC50, HT-29 cells) |
HDAC5 2.85 nM (IC50, HT-29 cells) |
HDAC1 1483 nM (IC50, HT-29 cells) |
HDAC11 4851 nM (IC50, HT-29 cells) |
Class I/IIb >4000 nM (IC50, HT-29 cells) |
HDAC6 5035 nM (IC50, HT-29 cells) |
体外実験
NT376 (1.26-5035 nM, 3 h) exhibits high selectivity and high potency to class-IIa Histone deacetylases (HDAC)s (IC50=32 nM) over other HDAC classes (IC50= >4.0 µM), performing slightly better than NT160 (HY-149285) in the functional cell-based assay in HT-29 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 2820208-97-5
-
分子量 436.40
-
分子式 C21H20F4N4O2
-
SMILES
O=C(N[C@H](C)CN(CC1=CC=CC=C1)C)C2=CC=C(C3=NOC(C(F)(F)F)=N3)C=C2F
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NT376 関連分類
HY-163806 関連分類
Powered by Bioz