OUL245
OUL245 is a 7-Hydroxy derivative, and a selectively PARP2 inhibitor (IC50=44 nM). OUL245 also inhibits other PARP and TNKS enzymes with IC50s of 2.9-8.8 μM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1023814-45-0
- 分子式: C8H5N3OS
- 分子量:191.21
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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PARP2 44 nM (IC50) |
PARP-1 570 nM (IC50) |
PARP3 8.8 μM (IC50) |
PARP4 6.0 μM (IC50) |
TNKS1 1.6 μM (IC50) |
TNKS2 370 μM (IC50) |
PARP10 2.9 μM (IC50) |
PARP14 6.7 μM (IC50) |
PARP15 2.0 μM (IC50) |
OUL245 (1 μM; 10-12 d) unlike other derivatives, does not save cells overexpressing PARP10 from ADP ribosylation-dependent cell death[1].
Pharmacokinetic Analysis[1]
| water solubility μg/mL | GI Papp×10-6 cm/s (RM %) | BBB Papp×10-6 cm/s (RM %) | metabolic stablity % | stab in human plasma | stab. in MeOH | stab in PBS pH 7.4 |
| 24.91 | 0.019 | 0.164 | 95.05 | >24 | >24 | >24 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1023814-45-0
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分子量 191.21
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分子式 C8H5N3OS
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SMILES
C1=CC2=C(C=C1O)SC3=NN=CN23
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
OUL245 関連分類
HY-W294889 関連分類
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