OUL245
OUL245 is a 7-Hydroxy derivative, and a selectively PARP2 inhibitor (IC50=44 nM). OUL245 also inhibits other PARP and TNKS enzymes with IC50s of 2.9-8.8 μM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1023814-45-0
- 分子式: C8H5N3OS
- 分子量:191.21
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
PARP2 44 nM (IC50) |
PARP-1 570 nM (IC50) |
PARP3 8.8 μM (IC50) |
PARP4 6.0 μM (IC50) |
TNKS1 1.6 μM (IC50) |
TNKS2 370 μM (IC50) |
PARP10 2.9 μM (IC50) |
PARP14 6.7 μM (IC50) |
PARP15 2.0 μM (IC50) |
体外実験
OUL245 (1 μM; 10-12 d) unlike other derivatives, does not save cells overexpressing PARP10 from ADP ribosylation-dependent cell death[1].
Pharmacokinetic Analysis[1]
| water solubility μg/mL | GI Papp×10-6 cm/s (RM %) | BBB Papp×10-6 cm/s (RM %) | metabolic stablity % | stab in human plasma | stab. in MeOH | stab in PBS pH 7.4 |
| 24.91 | 0.019 | 0.164 | 95.05 | >24 | >24 | >24 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 1023814-45-0
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分子量 191.21
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分子式 C8H5N3OS
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SMILES
C1=CC2=C(C=C1O)SC3=NN=CN23
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
OUL245 関連分類
HY-W294889 関連分類
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