Pseudouridimycin TFA
Pseudouridimycin (PUM) TFA is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin TFA is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin TFA inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis.
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- CAS 番号: 2760807-99-4
- 分子式: C19H27F3N8O11
- 分子量:600.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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RNA Polymerase |
Pseudouridimycin (PUM) TFA is selective because of its side chain that binds in a region that is conserved in bacterial RNA polymerases but not in humans. In vitro bactericidal activity is reported for Pseudouridimycin TFA against drug-sensitive, drug-resistant, and multidrug-resistant Streptococcus species[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female ICR mice (23-25 g) intraperitoneal injection of 0.5 mL saline solution (supplemented with 1% peptone) containing 4 × 103 cfu S. pyogenes C203[3].
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Dosage:3.2 mg/kg, 8 mg/kg, 20 mg/kg, 50 mg/kg
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Administration:iv; 10 min after infection and again 6 h after infection
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Result:Showed antibacterial activity in vivo.
化学情報
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CAS 番号 2760807-99-4
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分子量 600.46
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分子式 C19H27F3N8O11
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SMILES
O=C1NC(C([C@H]2[C@@H]([C@@H]([C@@H](CNC([C@H](CCC(N)=O)N(C(CNC(N)=N)=O)O)=O)O2)O)O)=CN1)=O.OC(C(F)(F)F)=O
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別名
PUM TFA
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Rosenqvist P, et al. Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin. Sci Rep. 2019 Jun 20;9(1):8935. [Content Brief]
[2]. Kunthavai Pavundurai Chandra, et al. Pseudouridimycin-A Potent Nucleoside Inhibitor of the RNA. ACS Omega. 2023 Feb 13;8(8):7989-8000. [Content Brief]
[3]. Maffioli SI, et al. Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell. 2017 Jun 15;169(7):1240-1248.e23. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Pseudouridimycin TFA 関連分類
HY-125650A 関連分類
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