SH491
SH491 (Compound 33) is an antiosteoporosis agent. SH491 inhibits RANKL-induced osteoclast differentiation on bone-marrow-derived monocytes (BMMs) (IC50: 11.8 nM). SH491 inhibits the expression of osteoclastogenesis-related marker genes (TRAP, CTSK, MMP-9, and ATPase v0d2) and proteins (TRAP, CTSK, MMP-9).
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- CAS 番号: 2975285-28-8
- 分子式: C33H50N2O
- 分子量:490.76
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BMMC | IC50 |
10.3 nM
Compound: 33; SH491
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Anti-osteoclastogenic activity in C57/BL6 mouse BMMC cells assessed as inhibition of RANKL-induced osteoclast differentiation incubated for 5 to 7 days in presence of M-CSF by TRAP staining based microscopic analysis relative to control
Anti-osteoclastogenic activity in C57/BL6 mouse BMMC cells assessed as inhibition of RANKL-induced osteoclast differentiation incubated for 5 to 7 days in presence of M-CSF by TRAP staining based microscopic analysis relative to control
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[PMID: 37597216] |
化学情報
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CAS 番号 2975285-28-8
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分子量 490.76
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分子式 C33H50N2O
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SMILES
C[C@]12[C@]([H])(C(C)(C)C3=C(C2)C=NC(C)=N3)CC[C@@]4([C@@]1(C[C@H]([C@]5([C@]4(CC[C@@H]5C(CC/C=C(C)\C)=C)C)[H])O)[H])C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SH491 関連分類
HY-155960 関連分類
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