SIJ1777
SIJ1777 is a GNF-7 (HY-10943) derivative, possesses potent anti-cancer effects on melanoma cells harboring BRAF class I/II/III mutations. SIJ1777 substantially inhibits the activation of MEK, ERK, and AKT. SIJ1777 remarkably induces apoptosis and significantly blocks migration, invasion, and anchorage-independent growth of melanoma cells harboring BRAF class I/II/II mutations.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 839707-55-0
- 分子式: C26H23F3N8O2
- 分子量:536.51
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
SIJ1777 possesses 2 to 14-fold enhanced anti-proliferative activities compared with GNF-7 (HY-10943) against melanoma cells (SK-MEL-2, SK-MEL-28, A375, WM3670, WM3629)[1].
SIJ1777 completely suppressed phospho-MEK, -ERK, and -AKT levels at 1 μM concentration, regardless of BRAF mutation status in melanoma cells[1].
SIJ1777 increases cleaved PARP level in a concentration-dependent manner on melanoma cells (SK-MEL-2, SK-MEL-28, C8161, WM3629)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 839707-55-0
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分子量 536.51
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分子式 C26H23F3N8O2
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SMILES
O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=NN(C)C=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SIJ1777 関連分類
HY-164400 関連分類
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