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Tomaralimab

(別名: OPN-305)
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Based on 1 Customer Validation

Tomaralimab (OPN-305) is a humanized anti-TLR2 IgG4 monoclonal antibody. Tomaralimab inhibits TLR2, MyD88, NLRP3, and reduces pro-inflammatory cytokine (IL-1β, IL-6, IL-8) production. Tomaralimab reduces tau pathology. Tomaralimab improves cognition, atopic dermatitis. Tomaralimab has anticancer effects on pancreatic ductal adenocarcinoma. Tomaralimab is being studied in myelodysplastic syndrome (MDS), atopic dermatitis, pancreatic ductal adenocarcinoma, Alzheimer's disease, and myocardial ischemia/reperfusion injury.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度: 99.42%
  • CAS 番号: 1449294-76-1
  • 分子量:145.32 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tomaralimab
  • Experimental Validation Results for Tomaralimab
  • Experimental Validation Results for Tomaralimab
  • Tomaralimab Chemical Structure
    Tomaralimab 構造式
CAS 番号: 1449294-76-1
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized Human TLR2 Protein can bind Tomaralimab. The EC50 for this effect is 649.63 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5X106 THP-1 cells with Tomaralimab (HY-P99555, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa, Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Tomaralimab Chemical Structure
    1/16
  • Tomaralimab
  • Immobilized Human TLR2 Protein can bind Tomaralimab. The EC50 for this effect is 649.63 ng/mL.
  • Flow cytometric analysis of 1.5X106 THP-1 cells with Tomaralimab (HY-P99555, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa, Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).