Tylvalosin
Based on 2 publication(s) in Google Scholar
Tylvalosin (Acetylisovaleryltylo?sin) is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin is an antiviral agent used to study PRRSV infection. Tylvalosin induces apoptosis. Tylvalosin also has anti-inflammatory activity, alleviates oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.00%
- CAS 番号: 63409-12-1
- 分子式: C53H87NO19
- 分子量:1042.25
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Tylvalosin
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生物活性
Tylvalosin (10 μg/mL; 0.5, 1 h) increases caspase-3 cleavage in porcine neutrophils, leading to DNA fragmentation during apoptosis[4].
Tylvalosin (0.1-10 μg/mL; 0.5 h) promotes endocytosis of porcine neutrophils by macrophages without changing phagocytosis[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Porcine neutrophils
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Concentration:0.1, 1.0, or 10 µg/mL
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Incubation Time:0.5, 1 h
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Result:Resulted induction of concentration- and time-dependent apoptosis in porcine monocyte-derived macrophages.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:PRRSV-free commercial breed piglets[5]
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Dosage:800 mg/kg Aivlosin (20% Tylvalosin Tartrate Premix)
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Administration:po; 7-14 days
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Result:Attenuated the increase in total white blood cells induced by immunization at day one post-immunization (DPI) and induced an increase in monocyte counts after seven DPI.
Attenuate the reduction in the percentage of CD8+ T cells induced by PRRSV-inactivated vaccine immunization at seven DPI.
化学情報
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CAS 番号 63409-12-1
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性状 Solid
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分子量 1042.25
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分子式 C53H87NO19
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Color White to off-white
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SMILES
O[C@@H]1[C@@H](C)O[C@@H](OC[C@H]([C@@H](CC)OC(C[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC(CC(C)C)=O)[C@@](O)(C)C3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@H]4C)=O)/C=C(C)/C=C/C4=O)[C@H](OC)[C@@H]1OC
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別名
Acetylisovaleryltylosin
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
De novo design mini-binder proteins targeting the capsid-forming domain of type 2 PRRSV nucleocapsid protein to inhibit PRRSV replication in vitro. [Abstract]2025 Aug 26;323(Pt 2):147118. PMID: 40865823 -
Rapid Commun Mass Spectrom
2025;39(20):e10103. PMID: 40589310
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (95.95 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (281 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Albert Philip Adrian Mockett, et al. Use of tylvalosin as antiviral agent. Patent. WO2008007104.
[2]. Zhao Z, et al. Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-κB activation. Biochem Pharmacol. 2014 Jul 1;90(1):73-87. [Content Brief]
[3]. Moges R, et al. Anti-Inflammatory Benefits of Antibiotics: Tylvalosin Induces Apoptosis of Porcine Neutrophils and Macrophages, Promotes Efferocytosis, and Inhibits Pro-Inflammatory CXCL-8, IL1α, and LTB4 Production, While Inducing the Release of Pro-Resolving Lipoxin A4 and Resolvin D1. Front Vet Sci. 2018 Apr 11;5:57. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9595 mL | 4.7973 mL | 9.5946 mL | 23.9866 mL |
| 5 mM | 0.1919 mL | 0.9595 mL | 1.9189 mL | 4.7973 mL | |
| 10 mM | 0.0959 mL | 0.4797 mL | 0.9595 mL | 2.3987 mL | |
| 15 mM | 0.0640 mL | 0.3198 mL | 0.6396 mL | 1.5991 mL | |
| 20 mM | 0.0480 mL | 0.2399 mL | 0.4797 mL | 1.1993 mL | |
| 25 mM | 0.0384 mL | 0.1919 mL | 0.3838 mL | 0.9595 mL | |
| 30 mM | 0.0320 mL | 0.1599 mL | 0.3198 mL | 0.7996 mL | |
| 40 mM | 0.0240 mL | 0.1199 mL | 0.2399 mL | 0.5997 mL | |
| 50 mM | 0.0192 mL | 0.0959 mL | 0.1919 mL | 0.4797 mL | |
| 60 mM | 0.0160 mL | 0.0800 mL | 0.1599 mL | 0.3998 mL | |
| 80 mM | 0.0120 mL | 0.0600 mL | 0.1199 mL | 0.2998 mL |
Tylvalosin 関連分類
HY-128423A 関連分類
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