Verproside
Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive and anti-asthmatic activities. Verproside has the potential for the study of chronic obstructive pulmonary disease (COPD).
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- CAS 番号: 50932-20-2
- 分子式: C22H26O13
- 分子量:498.43
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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NF-κB |
IKK |
Verproside (2.5-20 μM; for 2 hours) markedly reduces phosphorylation levels of IKKα/β, IκBα, and TAK1 in the 5-20 μM range[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NCI-H292 cells
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Concentration:2.5, 5, 10, 20 μM
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Incubation Time:2 hours
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Result:Resulted in markedly reduced phosphorylation levels of IKKα/β, IκBα, and TAK1.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Specific pathogen-free female BALB/c mice aged 8-10 weeks[2]
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Dosage:30 mg/kg
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Administration:Intragastrically; 48 hours
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Result:Reduced significantly the immunoglobulin E (IgE) levels.
化学情報
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CAS 番号 50932-20-2
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分子量 498.43
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分子式 C22H26O13
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SMILES
OC1=C(O)C=CC(C(O[C@@H]2[C@H]3[C@@](O3)(CO)[C@@]([C@@]2([H])C=CO4)([H])[C@@H]4O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)=O)=C1
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Lee SU, et al. Verproside inhibits TNF-α-induced MUC5AC expression through suppression of the TNF-α/NF-κB pathway in human airway epithelial cells. Cytokine. 2016 Jan;77:168-75. [Content Brief]
[2]. Oh SR, et al. Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma. Int Immunopharmacol. 2006 Jun;6(6):978-86. Epub 2006 Feb 10. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Verproside 関連分類
HY-126232 関連分類
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