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Alisertib

(Synonyms: MLN 8237)
73 Cited Publications
고객리뷰

Based on 73 publication(s) in Google Scholar

Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC50=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity.

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  • Purity: 99.36%
  • CAS No.: 1028486-01-2
  • 화학식: C27H20ClFN4O4
  • 분자량:518.92
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Alisertib Chemical Structure
  • Experimental Validation Results for Alisertib
  • Experimental Validation Results for Alisertib
  • Experimental Validation Results for Alisertib
  • Alisertib Chemical Structure
    Alisertib Chemical Structure
  • Experimental Validation Results for Alisertib
  • Experimental Validation Results for Alisertib
  • Experimental Validation Results for Alisertib
CAS No.: 1028486-01-2
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IFIHCWB
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All Aurora Kinase Isoforms

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  • Alisertib Chemical Structure
    Alisertib Chemical Structure
    1/16
  • 1/16

    Alisertib purchased from MedChemExpress. Usage Cited in: FASEB J. 2018 May;32(5):2735-2746. [Abstract]

    Customer Validation
     Representative immunofluorescence (IF) image and graph with frequency of ciliated WT or Pkd12/2 murine renal epithelial cells at 2 h after treatment with vehicle (V), Ganetespib (G), or Alisertib (A) to inhibit AURKA, or (C) combination of Alisertib and Ganetespib. On IF, acetylated a-tubulin (red); g-tubulin (green); DAPI (blue).

  • 1/16

    Alisertib purchased from MedChemExpress. Usage Cited in: Drexel University. 2016 Nov.

    Customer Validation
     Alisertib and combination treatment suppress proliferation in BT474 orthotopic tumors as shown by decrease in Ki-67, which is statistically significantly different between vehicle and combination treatment, FRAX1036 and Alisertib, and FRAX1036 and combination treatment.

  • 1/16

    Alisertib purchased from MedChemExpress. Usage Cited in: Drexel University. 2016 Nov.

    Customer Validation
     Alisertib enhances FRAX1036 inhibitory effect on PAK1 phosphorylation in BT474 xenograft model.

  • Alisertib