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Doramapimod

(Synonyms: BIRB 796)
52 Cited Publications
고객리뷰

Based on 52 publication(s) in Google Scholar

Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (Kd=0.1 nM). Doramapimod also inhibits B-Raf with an IC50 of 83 nM.

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  • Purity: 99.93%
  • CAS No.: 285983-48-4
  • 화학식: C31H37N5O3
  • 분자량:527.66
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Doramapimod Chemical Structure
    Doramapimod Chemical Structure
  • Experimental Validation Results for Doramapimod
  • Experimental Validation Results for Doramapimod
  • Experimental Validation Results for Doramapimod
  • Experimental Validation Results for Doramapimod
  • Experimental Validation Results for Doramapimod
CAS No.: 285983-48-4
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IP2D/3D Cell Culture and DifferentiationWBIF
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  • 2D/3D Cell Culture and Differentiation
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All p38 MAPK Isoforms

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  • Doramapimod Chemical Structure
    Doramapimod Chemical Structure
    1/16
  • 1/16

    Doramapimod purchased from MedChemExpress. Usage Cited in: Engineering. 2025 Mar 4.

    Customer Validation
     BIRB 796 (10 μM, 36 h) inhibited the expression of p-p38 MAPK induced by LPS (200 ng/mL) in THP-1 cells.

  • 1/16

    Doramapimod purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Sep 6:76:103344. [Abstract]

    Customer Validation
     BIRB 796 (DORA, 10 μM, 4 h) inhibited the expression of p-p38 MAPK induced by LPS (1000 ng/mL) in 10T1/2 cells.

  • 1/16

    Doramapimod purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Sep 6:76:103344. [Abstract]

    Customer Validation
     BIRB 796 (DORA, 10 μM, 4 h) inhibited the mitochondrial recruitment of DRP1 and the fission induced by LPS (1000 ng/mL) in 10T1/2 cells.

  • 1/16

    Doramapimod purchased from MedChemExpress. Usage Cited in: Cell Res. 2020 Jul;30(7):574-589. [Abstract]

    Customer Validation
     Birb 796 (0.1, 0.3, 1, and 3 μM, 3 days) impaired the ability of SSK1 (0.5 μM,3 days) to specifically kill senescent HUVEC.

  • 1/16

    Doramapimod purchased from MedChemExpress. Usage Cited in: Nature. 2019 Jul;571(7763):127-131. [Abstract]

    Customer Validation
     BIRB 796 (1 μM, 4.5 h) did not abrogate EGF-induced pUGDH in A549 cells stably expressing Flag–UGDH.

  • Doramapimod