MHP 133
MHP 133 is a agent with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.
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- CAS No.: 147340-43-0
- 화학식: C17H20ClN5O3
- 분자량:377.83
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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HY-N0342
ScopoletinCholinesterase (ChE) Inhibitor -
HY-N0342R
Scopoletin (Standard)Cholinesterase (ChE) Inhibitor -
HY-A0009
Galanthamine hydrobromideAChE Inhibitor -
HY-75247
CoumaranAChE Inhibitor -
HY-103374
PhenserineAChE Inhibitor -
HY-17388
(±)-Huperzine ADrug Isomer -
HY-75247R
Coumaran (Standard)AChE Inhibitor -
HY-A0009R
Galanthamine hydrobromide (Standard)AChE Inhibitor
All 5-HT Receptor Isoforms
More
Biological Activity
제품 설명
IC50 & Target
[1]|
mAChR1 |
mAChR2 |
5-HT4 Receptor |
AChE 69 μM (Ki) |
In Vitro
MHP-133 is be active (>50% displacement or activity) against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors. MHP-133 exhibits this nicotinic-like activity in the cell line. Although the ED50 for inducing TrkA expression is only about 1 μM, it does predicts the cytoprotective action of MHP-133 in differentiated PC-12 cells deprived of growth factor for 24 h. MHP-133 (10-100 μM) significantly increases the levels of sAPP from cultured astrocytes by 40-60%. MHP-133 produces a bi-phasic effect on slice survival, particularly in the dentate gyrus and the CA1 regions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 147340-43-0
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분자량 377.83
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화학식 C17H20ClN5O3
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SMILES
O=C(N/N=C/C1=C(OC(N(C)C)=O)C=CC=[N+]1C)NC2=CC=CC=C2.[Cl-]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MHP 133 Related Classifications
HY-101653 Related Classifications
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