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Cat. No.: HY-N10782

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Balanophonin

Balanophonin is an anti-inflammatory and anti-cancer agent. Balanophonin inhibits microglial activation and neurodegeneration via inhibiting activated microglia-induced apoptosis.

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CAS No.: 80286-36-8
화학식: C₂₀H₂₀O₆
분자량:356.37

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Balanophonin Chemical Structure

CAS No.: 80286-36-8

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Balanophonin is an anti-inflammatory and anti-cancer agent. Balanophonin inhibits microglial activation and neurodegeneration via inhibiting activated microglia-induced apoptosis^[1].

IC₅₀ & Target

^[1]

COX-2

p38

All COX Isoforms :

All TNF Receptor Isoforms :

All p38 MAPK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	7.07 μM Compound: 11	Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 26774654]
Hep 3B2	IC₅₀	31.5 μM Compound: 1b	Cytotoxicity against human Hep3B cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human Hep3B cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 29567344]
HepG2	IC₅₀	38.7 μM Compound: 1b	Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 29567344]

In Vitro

Balanophonin (1-10 μM; 24 h) reduces Lipopolysaccharides (LPS; HY-D1056)-mediated TLR4 activation and NO production in BV2 cells^[1].
Balanophonin (1-10 μM; 6 h) reduces iNOS and COX2 protein expression and TNF-α and IL-1β production in LPS-induced microglial cells^[1].
Balanophonin (1-10 μM; 30 min) effectively inhibits MAPK activation^[1].
Balanophonin (1-10 μM; 24 h) inhibits neuronal cell death resulting from LPS-activated microglia by regulating cleaved caspase-3 and poly ADP ribose polymerase (PARP) cleavage in N2a cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

LPS-activated BV-2 cells
Concentration:

1, 5, and 10 μM
Incubation Time:

30 min for MAPKs, 6 h for iNOS and COX2 and 24 h for PGE2, TNF-α and IL-1β
Result:

Downregulated TLR4. Reduced iNOS and COX2 expression. Significantly reduced the secretion of TNF-α and IL-1β. Decreased the phosphorylation of MAPKs such as pERK, pJNK, and p-p38.

Western Blot Analysis^[1]

Cell Line:

Neuroblastoma N2a cells
Concentration:

1, 5, and 10 μM
Incubation Time:

24 h
Result:

Slightly increased Bcl-2. Inhibited caspase-3 activation and PARP cleavage.

Chemical Information

CAS No. 80286-36-8
분자량 356.37
화학식 C₂₀H₂₀O₆
SMILES

OC[C@@H]1C2=CC(/C=C/C=O)=CC(OC)=C2O[C@H]1C3=CC(OC)=C(C=C3)O
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lim SY, et al. A New Neolignan Derivative, Balanophonin Isolated from Firmiana simplex Delays the Progress of Neuronal Cell Death by Inhibiting Microglial Activation. Biomol Ther (Seoul). 2017 Sep 1;25(5):519-527. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Balanophonin

All COX Isoforms

All TNF Receptor Isoforms

All p38 MAPK Isoforms