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Cat. No.: HY-100855

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DC_C66

DC_C66 is a cell-permeable, selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC₅₀ of 1.8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC₅₀=21 μM), PRMT6 (IC₅₀= 47μM), and PRMT5.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 108181-00-6
화학식: C₂₈H₂₂NO₂⁺
분자량:404.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

DC_C66 Chemical Structure

CAS No.: 108181-00-6

사이즈

가격

재고

수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC50: 1.8 μM (CARM1)^[1]

All Histone Methyltransferase Isoforms :

In Vitro

DC_C66 (6.25-100 μM; 24-72 hours) exhibits antiproliferation activity in several CARM1-associated cancer cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HELA, K562, MCF7 cells
Concentration:

6.25, 12.5, 25, 50, 100 μM
Incubation Time:

24, 48, 72 hours
Result:

Inhibits proliferation of cancer cells in a time-dependent and dose-dependent manner in HELA, K562, and MCF7 cells.

Chemical Information

CAS No. 108181-00-6
분자량 404.48
화학식 C₂₈H₂₂NO₂⁺
SMILES

O=C(OCC)C1=[N+]2C(C(C=CC=C3)=C3CC2)=CC4=C1C(C=CC=C5)=C5C6=C4C=CC=C6
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ye F, et al. Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays. Biomed Res Int. 2016;2016:7086390. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

DC_C66

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

DC_C66 Related Classifications

HY-100855 Related Classifications