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Cat. No.: HY-183387

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K11002 hydrobromide

K11002 hydrobromide is a cysteine protease inhibitor. K11002 hydrobromide forms a covalent bond with the active site cysteine residue via Michael addition. K11002 hydrobromide inhibits the growth of Trypanosoma brucei. K11002 hydrobromide can be used in the research of African human trypanosomiasis (sleeping sickness).

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CAS No.: 1348565-08-1
화학식: C₃₁H₃₆BrN₃O₅S
분자량:642.60

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

K11002 hydrobromide Chemical Structure

CAS No.: 1348565-08-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
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Biological Activity

제품 설명

All Parasite Isoforms :

All Cathepsin Isoforms :

In Vitro

Hydrobromide form of K11002 (24 h potently inhibits the growth of bloodstream-form and anterior-circulation-form Trypanosoma brucei, with ED₅₀ values of 4.1 nM and 7.0 nM respectively after 24 h of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1348565-08-1
분자량 642.60
화학식 C₃₁H₃₆BrN₃O₅S
SMILES

O=S(/C=C/[C@H](CCC1=CC=CC=C1)NC([C@@H](NC(N2CCOCC2)=O)CC3=CC=CC=C3)=O)(C4=CC=CC=C4)=O.Br
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Yang PY, et al. Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei. Chemical communications (Cambridge, England). 2012 Jan 21;48(6):835-7. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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K11002 hydrobromide

All Parasite Isoforms

All Cathepsin Isoforms