Leukotriene E4-d5
Based on 1 Customer Validation
Leukotriene E4-d5 (LTE4-d5) is the d-5-labeled Leukotriene E4 (HY-113465). Leukotriene E4 is a stable final metabolite of cysteinyl leukotrienes, produced by immune cells such as mast cells and eosinophils. Leukotriene E4 serves as a key biomarker for evaluating asthma severity, Aspirin (HY-14654) sensitivity, and mast cell activation disorders. Leukotriene E4 is a full functional agonist of CysLT1R, which induces sustained intracellular calcium mobilization and Erk phosphorylation. Leukotriene E4 mediates inflammation in a P2Y12 receptor-dependent manner. Leukotriene E4 can be used in the research of asthma and non-steroidal anti-inflammatory drug-exacerbated respiratory diseases.
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- Purity: 98.5%
- CAS No.: 1240398-14-4
- 화학식: C23H32D5NO5S
- 분자량:444.64
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보관:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
MoreAll Leukotriene Receptor Isoforms
MoreAll Calcium Channel Isoforms
MoreAll P2Y Receptor Isoforms
More
Biological Activity
제품 설명
신청
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1240398-14-4
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Unlabeled CAS 75715-89-8
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Appearance Liquid
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분자량 444.64
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화학식 C23H32D5NO5S
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Color Colorless to light yellow
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SMILES
OC(CCC[C@H](O)[C@@H](/C=C/C=C/C=C\C/C=C\CCCC([2H])([2H])C([2H])([2H])[2H])SC[C@H](N)C(O)=O)=O
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Synonyms
LTE4-d5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Solution, -20°C, 2 years
순도&문서
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Data Sheet (263 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Leukotriene E4-d5 Related Classifications
HY-113465S Related Classifications
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Keywords
- Leukotriene E4-d5
- 1240398-14-4
- LTE4-d5
- Isotope-Labeled Compounds
- Endogenous Metabolite
- Leukotriene Receptor
- Calcium Channel
- ERK
- P2Y Receptor
- CysLT1
- HEK293T cells
- BALB/c mice
- C57BL/6 mice
- P2Y12
- NSAID-exacerbated respiratory disease
- Chinese hamster ovary cells
- LAD2 human mast cells
- LUVA human mast cells
- asthma
- Inhibitor
- inhibitor
- inhibit