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Cat. No.: HY-187134

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mTOR-IN-31

mTOR-IN-31 is a selective mTOR inhibitor with an IC₅₀ of 0.9 nM. mTOR-IN-31 inhibits the proliferation of prostate cancer cells. mTOR-IN-31 is applicable for cancer-related research.

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CAS No.: 1144075-32-0
화학식: C₂₀H₂₁N₅O₂S
분자량:395.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

mTOR-IN-31 Chemical Structure

CAS No.: 1144075-32-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

mTOR-IN-31 is a selective mTOR inhibitor with an IC₅₀ of 0.9 nM. mTOR-IN-31 inhibits the proliferation of prostate cancer cells. mTOR-IN-31 is applicable for cancer-related research^[1].

IC₅₀ & Target^[1]

mTOR

0.9 nM (IC₅₀)

PI3Kα

423 nM (IC₅₀)

All mTOR Isoforms :

All PI3K Isoforms :

In Vitro

mTOR-IN-31 (compound 9a) potently inhibits recombinant mTOR with an IC₅₀ of 0.9 nM, and exhibits over 1000-fold selectivity against recombinant PI3K-α^[1].
mTOR-IN-31 inhibits the proliferation of human prostate cancer cell line LNCaP (IC₅₀ = 85 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1144075-32-0
분자량 395.48
화학식 C₂₀H₂₁N₅O₂S
SMILES

O=C(NC)NC1=CC=C(C2=NC3=C(C(N4CC5OC(CC5)C4)=N2)SC=C3)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Verheijen J C, et al. Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabicyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorg Med Chem Lett, 2010, 20(1): 375-379.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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mTOR-IN-31

All mTOR Isoforms

All PI3K Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

mTOR-IN-31 Related Classifications

HY-187134 Related Classifications