Nexopamil
Based on 1 Customer Validation
Nexopamil is a calcium antagonist of Ca2+ channel, 5HT2, 5HT1A, 5HT1C and dopamine D2 receptors. Nexopamil exhibits vasodilatory, cardioprotective, and platelet aggregation inhibiting effects. Nexopamil can be used for researches of stable or unstable angina and possibly of peripheral arterial occlusive disease.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.57%
- CAS No.: 136033-49-3
- 화학식: C24H40N2O3
- 분자량:404.59
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
All Calcium Channel Isoforms
MoreAll 5-HT Receptor Isoforms
MoreAll Dopamine Receptor Isoforms
More
Biological Activity
제품 설명
IC50 & Target
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5-HT1A Receptor |
5-HT1C Receptor |
Chemical Information
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CAS No. 136033-49-3
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Appearance Solid
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분자량 404.59
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화학식 C24H40N2O3
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Color White to off-white
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SMILES
CCCCCCN(C)CCC[C@@](C#N)(C1=CC(OC)=C(OC)C(OC)=C1)C(C)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 100 mg/mL (247.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
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Ca2+ Staining Technique
Ca2+ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca2+ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
순도&문서
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.4716 mL | 12.3582 mL | 24.7164 mL | 61.7909 mL |
| 5 mM | 0.4943 mL | 2.4716 mL | 4.9433 mL | 12.3582 mL | |
| 10 mM | 0.2472 mL | 1.2358 mL | 2.4716 mL | 6.1791 mL | |
| 15 mM | 0.1648 mL | 0.8239 mL | 1.6478 mL | 4.1194 mL | |
| 20 mM | 0.1236 mL | 0.6179 mL | 1.2358 mL | 3.0895 mL | |
| 25 mM | 0.0989 mL | 0.4943 mL | 0.9887 mL | 2.4716 mL | |
| 30 mM | 0.0824 mL | 0.4119 mL | 0.8239 mL | 2.0597 mL | |
| 40 mM | 0.0618 mL | 0.3090 mL | 0.6179 mL | 1.5448 mL | |
| 50 mM | 0.0494 mL | 0.2472 mL | 0.4943 mL | 1.2358 mL | |
| 60 mM | 0.0412 mL | 0.2060 mL | 0.4119 mL | 1.0298 mL | |
| 80 mM | 0.0309 mL | 0.1545 mL | 0.3090 mL | 0.7724 mL | |
| 100 mM | 0.0247 mL | 0.1236 mL | 0.2472 mL | 0.6179 mL |
Nexopamil Related Classifications
HY-106904 Related Classifications
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