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Cat. No.: HY-N7385

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Nudol

고객리뷰

Based on 1 Customer Validation

Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits MMP-2M and MMP-9 activity (K_i: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.60%
CAS No.: 86630-46-8
화학식: C₁₆H₁₄O₄
분자량:270.28

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Nudol Chemical Structure

CAS No.: 86630-46-8

사이즈

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수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[2]

MMP-2

988.9 nM (Ki)

MMP-9

1.76 μM (Ki)

All MMP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>10 μM Compound: 15	Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay	[PMID: 27310249]
HeLa	IC₅₀	>10 μM Compound: 15	Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay	[PMID: 27310249]
HSC-T6	IC₅₀	>100 μM Compound: 13	Antiproliferative activity against rat HSC-T6 cells after 48 hrs by MTT assay Antiproliferative activity against rat HSC-T6 cells after 48 hrs by MTT assay	[PMID: 18052323]
MCF7	IC₅₀	>10 μM Compound: 15	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay	[PMID: 27310249]
Neutrophil	IC₅₀	>10 μM Compound: 11	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction	[PMID: 27525452]
Neutrophil	IC₅₀	1.7 μM Compound: 11	Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/cytochalasin B-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by FMLP/cytochal Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/cytochalasin B-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by FMLP/cytochal	[PMID: 27525452]

In Vitro

Nudol (0-40 μM, 24-72 h) decreases cell viability in several cancer cell lines^[1].
Nudol (0-20 μM, 24/48 h) suppresses the cell migration and causes cell cycle arrest at G2/M phase in U2OS cells^[1].
Nudol (20 μM, 48 h) induces cell apoptosis through the caspase-dependent pathway in U2OS cells^[1].
Nudol (compound 4) inhibits MMP-2 and MMP-9 activity with K_i values of 988.9 nM and 1.76 μM respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

U2OS, MG63, MDA-MB-231, MCF-7, and A549 cells
Concentration:

0, 10, 20, 30, 40 μM
Incubation Time:

24, 48, and 72 h
Result:

Decreased the cell viability of osteosarcoma cells in dose- and time-dependent manners.

Cell Cycle Analysis^[1]

Cell Line:

U2OS cells
Concentration:

0, 5, 10, 20 μM
Incubation Time:

24, 48, and 72 h
Result:

Triggered G2/M phase arrest by decreasing cell cycle-related proteins (CDK1, CDK2, CDK4, and CDK10).

Western Blot Analysis^[1]

Cell Line:

U2OS cells
Concentration:

0, 5, 10, 20, 40 μM
Incubation Time:

24, 48, and 72 h
Result:

Increased the protein level of cytochrome c.
Down-regulated anti-apoptotic Bcl-2, accompanied by an increased level of pro-apoptotic Bax.

Chemical Information

CAS No. 86630-46-8
Appearance Solid
분자량 270.28
화학식 C₁₆H₁₄O₄
Color Off-white to light brown
SMILES

OC1=C(OC)C(OC)=C2C3=CC=C(O)C=C3C=CC2=C1
Structure Classification
- Phenols
- Polyphenols
Initial Source
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yuying Zhang, et al. Nudol, a phenanthrene derivative from Dendrobium nobile, induces cell cycle arrest and apoptosis and inhibits migration in osteosarcoma cells. Drug Des Devel Ther. 2019 Jul 29;13:2591-2601. [Content Brief]

[2]. Mohammad Al-Amin, et al. Inhibitory Effect of Dioscorea bulbifera Tubers on the Migration of Triple-Negative Breast Cancer Cells. Breast Cancer Cells. Rev. Bras. Farmacogn. 31, 335–341 (2021).

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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Nudol

High-Throughput Bioactive Compound Library

All MMP Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Nudol Related Classifications

HY-N7385 Related Classifications