Pseudouridimycin TFA
Pseudouridimycin (PUM) TFA is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin TFA is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin TFA inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis.
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- CAS No.: 2760807-99-4
- 화학식: C19H27F3N8O11
- 분자량:600.46
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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RNA Polymerase |
Pseudouridimycin (PUM) TFA is selective because of its side chain that binds in a region that is conserved in bacterial RNA polymerases but not in humans. In vitro bactericidal activity is reported for Pseudouridimycin TFA against drug-sensitive, drug-resistant, and multidrug-resistant Streptococcus species[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female ICR mice (23-25 g) intraperitoneal injection of 0.5 mL saline solution (supplemented with 1% peptone) containing 4 × 103 cfu S. pyogenes C203[3].
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Dosage:3.2 mg/kg, 8 mg/kg, 20 mg/kg, 50 mg/kg
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Administration:iv; 10 min after infection and again 6 h after infection
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Result:Showed antibacterial activity in vivo.
Chemical Information
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CAS No. 2760807-99-4
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분자량 600.46
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화학식 C19H27F3N8O11
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SMILES
O=C1NC(C([C@H]2[C@@H]([C@@H]([C@@H](CNC([C@H](CCC(N)=O)N(C(CNC(N)=N)=O)O)=O)O2)O)O)=CN1)=O.OC(C(F)(F)F)=O
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Synonyms
PUM TFA
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Rosenqvist P, et al. Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin. Sci Rep. 2019 Jun 20;9(1):8935. [Content Brief]
[2]. Kunthavai Pavundurai Chandra, et al. Pseudouridimycin-A Potent Nucleoside Inhibitor of the RNA. ACS Omega. 2023 Feb 13;8(8):7989-8000. [Content Brief]
[3]. Maffioli SI, et al. Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell. 2017 Jun 15;169(7):1240-1248.e23. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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