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Cat. No.: HY-160962

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SM1044

SM1044 is a dihydroartemisinin (DHA) dimer. SM1044 activates caspase, induces apooptosis in RL95-2 and KLE cells. SM1044 inhibits proliferations of cancer cells RL95-2, KLE, HEC-50, HEC-1-A, HEC-1-B, AN3CA, with IC₅₀ < 3.6 μM . SM1044 inhbits tumor growth in RL95-2 xenograft mouse model.

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CAS No.: 1331880-08-0
화학식: C₃₄H₅₅NO₁₀
분자량:637.80

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SM1044 Chemical Structure

CAS No.: 1331880-08-0

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Caspase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
AN3-CA	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human AN3-CA cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human AN3-CA cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
HEC-1-A	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human HEC-1-A cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HEC-1-A cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
HEC-1B cell line	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human HEC-1B cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HEC-1B cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
KLE	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human KLE cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human KLE cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
RL95-2	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human RL95-2 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human RL95-2 cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]

Chemical Information

CAS No. 1331880-08-0
분자량 637.80
화학식 C₃₄H₅₅NO₁₀
SMILES

C[C@@H]1[C@@]2([H])[C@]34[C@](O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C)([H])O[C@@H]1OCCNCCO[C@@H]5[C@@H]([C@@]6([H])[C@]78[C@](O[C@](OO7)(CC[C@@]8([H])[C@@H](CC6)C)C)([H])O5)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhu Y, et al., Novel dihydroartemisinin dimer containing nitrogen atoms inhibits growth of endometrial cancer cells and may correlate with increasing intracellular peroxynitrite. Sci Rep. 2019 Oct 29;9(1):15528. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

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SM1044

All Caspase Isoforms