TC-2153
Based on 1 Customer Validation
TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), with psychotropic activity and low acute toxicity. TC-2153 increases the expression of brain-derived neurotropic factor (BDNF) in the brain. And it decreases MAOA and 5-HT1A receptors mRNA level in midbrain. TC-2153 also inhibits 5-HT2A receptor-mediated signaling.
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- Purity: 98.19%
- CAS No.: 1381769-23-8
- 화학식: C7H5ClF3NS5
- 분자량:355.89
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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All 5-HT Receptor Isoforms
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Biological Activity
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5-HT1A Receptor |
5-HT2A Receptor |
MAO-A |
Acute TC-2153 treatment: TC-2153 (10 mg/kg and 20 mg/kg; p.o.; single dose) inhibits the functional activity of 5-HT2A receptors in vivo in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SPF-state adult mouse males[1]
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Dosage:10 mg/kg and 20 mg/kg; with or without 1 mg/kg DOI i.p. at 3 h after final treatment
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Administration:Oral gavage or intraperitoneal injection; single dose or once daily for 7 d
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Result:Showed antidepressant-like effect in the forced swim test without any adverse side effects on locomotor activity, anxiety, exploration, motor skill and obsessive-compulsive-like behavior.
Both acute and chronic methods inhibited the functional activity of 5-HT2A receptors.
Chemical Information
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CAS No. 1381769-23-8
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Appearance Solid
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분자량 355.89
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화학식 C7H5ClF3NS5
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Color Off-white to light yellow
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SMILES
NC1=C2SSSSSC2=CC(C(F)(F)F)=C1.[H]Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMSO : 100 mg/mL (280.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.02 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8099 mL | 14.0493 mL | 28.0986 mL | 70.2464 mL |
| 5 mM | 0.5620 mL | 2.8099 mL | 5.6197 mL | 14.0493 mL | |
| 10 mM | 0.2810 mL | 1.4049 mL | 2.8099 mL | 7.0246 mL | |
| 15 mM | 0.1873 mL | 0.9366 mL | 1.8732 mL | 4.6831 mL | |
| 20 mM | 0.1405 mL | 0.7025 mL | 1.4049 mL | 3.5123 mL | |
| 25 mM | 0.1124 mL | 0.5620 mL | 1.1239 mL | 2.8099 mL | |
| 30 mM | 0.0937 mL | 0.4683 mL | 0.9366 mL | 2.3415 mL | |
| 40 mM | 0.0702 mL | 0.3512 mL | 0.7025 mL | 1.7562 mL | |
| 50 mM | 0.0562 mL | 0.2810 mL | 0.5620 mL | 1.4049 mL | |
| 60 mM | 0.0468 mL | 0.2342 mL | 0.4683 mL | 1.1708 mL | |
| 80 mM | 0.0351 mL | 0.1756 mL | 0.3512 mL | 0.8781 mL | |
| 100 mM | 0.0281 mL | 0.1405 mL | 0.2810 mL | 0.7025 mL |
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