(±)-trans-BAS-2
(±)-trans-BAS-2 is a hHDAC6 inhibitor with an IC50 value of 0.462 μM. (±)-trans-BAS-2 serves as a scaffold for the design of proteolysis-targeting chimeras (PROTACs) and induces proteasome-dependent degradation of hHDAC6 in cells. (±)-trans-BAS-2 can be used in the research of triple-negative breast cancer and multiple myeloma.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 2790482-16-3
- 화학식: C13H21N3O2S
- 분자량:283.39
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
|
HDAC6 0.462 μM (IC50) |
(±)-trans-BAS-2 (compound 1) (0.462-30 μM; 1 h) potently inhibits recombinant full-length human HDAC6 with an IC50 of 0.462 μM[1].
(±)-trans-BAS-2 (10-12.68 μM; 24 h) induces dose-dependent cell death in MDA-MB-231 triple-negative breast cancer cells with an IC50 of 12.68 μM[1].
(±)-trans-BAS-2 (10-12.68 μM; 24 h) induces dose-dependent cell death in JJN3 multiple myeloma cells with an IC50 of 12.68 μM[1].
(±)-trans-BAS-2 (2 mM; 30 min) does not inhibit recombinant zebrafish HDAC6 CD2 at a concentration of 2 mM[1].
(±)-trans-BAS-2 (50 μM; 24 h) inhibits WT human HDAC6 activity in MDA-MB-231 cells, increasing acetyl-α-tubulin levels, but does not inhibit D567N mutant human HDAC6 activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MDA-MB-231 triple-negative breast cancer cells
-
Concentration:12.68 μM (IC50); 10 μM
-
Incubation Time:24 h
-
Result:Induced dose-dependent cell death in MDA-MB-231 cells, with an IC50 of 12.68 μM for cell death.
Caused 28.72% cell death at 10 μM.
-
Cell Line:JJN3 multiple myeloma cells
-
Concentration:12.68 μM (IC50); 10 μM
-
Incubation Time:24 h
-
Result:Induced dose-dependent cell death in JJN3 cells, with an IC50 of 12.68 μM for cell death.
Caused 28.72% cell death at 10 μM.
-
Cell Line:MDA-MB-231 cells transfected with WT or D567N human HDAC6-FLAG
-
Concentration:50 μM
-
Incubation Time:24 h
-
Result:Significantly increased acetyl-α-tubulin levels in cells transfected with WT human HDAC6-FLAG (densitometry value of ~12 × 104 relative units, normalized to FLAG).
Had no effect on acetyl-α-tubulin levels in cells transfected with D567N human HDAC6-FLAG.
Chemical Information
-
CAS No. 2790482-16-3
-
분자량 283.39
-
화학식 C13H21N3O2S
-
SMILES
[H][C@@]12[C@](NC(SCC(N3CCOCC3)=O)=N2)([H])CCCC1
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(±)-trans-BAS-2 Related Classifications
HY-184505 Related Classifications
Powered by Bioz