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Cat. No.: HY-184210

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XYD224

XYD224 is a selective BRD9 PROTAC degrader with a DC₅₀ of 7.3 nM. XYD224 inhibits the proliferation of acute myeloid leukemia cells. XYD224 suppresses tumor growth in xenograft models. XYD224 is applicable for the research of acute myeloid leukemia (AML).
(Pink: BRD9 ligand (HY-184211); Blue: Cereblon ligand (HY-179307); Black: linker).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₄₃H₅₁FN₆O₅
분자량:750.90

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

XYD224 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

XYD224 is a selective BRD9 PROTAC degrader with a DC₅₀ of 7.3 nM. XYD224 inhibits the proliferation of acute myeloid leukemia cells. XYD224 suppresses tumor growth in xenograft models. XYD224 is applicable for the research of acute myeloid leukemia (AML)^[1]. (Pink: BRD9 ligand (HY-184211); Blue: Cereblon ligand (HY-179307); Black: linker).

IC₅₀ & Target^[1]

BRD9

7.3 nM (DC₅₀)

Cereblon

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

In Vitro

XYD224 (0.0001-100 μM; 72-120 h) exhibits potent antiproliferative activity against multiple AML cell lines, with IC₅₀ values of 33 nM, 0.15 μM, 0.52 μM and 0.37 μM against MV4-11, MOLM-16, MOLM-13 and Kasumi-1, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MV4-11, MOLM-16, MOLM-13 and Kasumi-1 cells
Concentration:

0.0001, 0.01, 1, 100 μM
Incubation Time:

72 h (MOLM-16, MOLM-13 and Kasumi-1) and 120 h (MV4-11)
Result:

Had strong anti-proliferative activity against multiple AML cell lines.

Parmacokinetics

Species	Dose	Route	V_z	CL	T_1/2 (Elimination)
Rat^[1]	1 mg/kg	i.v.	148680 mL/kg	8816 mL/h/kg	12.03 h

In Vivo

XYD224 (10-20 mg/kg; i.p.; daily; 14 days) achieves tumor growth inhibition rates of 70% and 79%, respectively, with a favorable safety profile in the MV4-11 AML xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NOD/SCID (male, 4 weeks old, subcutaneous xenograft model via injection of 3 × 10⁶ MV4-11 cells)^[1]
Dosage:

10 mg/kg; 20 mg/kg
Administration:

i.p.; daily; 14 days
Result:

Achieved a tumor growth inhibition (TGI) rate of 70% at 10 mg/kg.
Achieved a TGI rate of 79% at 20 mg/kg.
Significantly reduced BRD9 protein levels in tumor tissues at both doses.
Caused no significant reduction in body weight.
Maintained serum levels of AST, CREA, and UREA within normal physiological ranges.
Caused no obvious histopathological changes in heart, liver, spleen, lung, or kidney tissues.

Chemical Information

분자량 750.90
화학식 C₄₃H₅₁FN₆O₅
SMILES

O=C(CCC1NC2=CC=C(C(F)=C2)N3CC4(C3)CCN(CC4)CC5CCN(CC5)CC6=C(OC)C=C(C=C6OC)C7=C8N(C(C(C)=O)=C7)C=CC=C8)NC1=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Tang X, et al. Discovery of a Highly Potent and Efficient BRD9 Degrader with Strong In Vivo Antitumor Activity. J Med Chem. 2026 Jun 11;69(11):13528-13550.
[Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

XYD224

All PROTACs Isoforms

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

XYD224 Related Classifications

HY-184210 Related Classifications