2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. HSP Estrogen Receptor/ERR
  4. Mequinol

Mequinol  (Synonyms: p-Hydroxyanisole)

Cat. No.: HY-30270 Purity: 99.93%
COA Handling Instructions

Molarity Calculator

Mequinol (4-Methoxyphenol)yes MercurialisOne of the bioactive ingredients, mainly used for skin discoloration. MequinolIs an antioxidant that has additive/synergistic effects on carcinogenesis when combined with other phenolic antioxidants. Mequinolalso promote hERαDependent chaperone production with potential estrogenic activity.

For research use only. We do not sell to patients.

Mequinol Chemical Structure

Mequinol Chemical Structure

CAS No. : 150-76-5

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of Mequinol:

Mequinol Related Antibodies

Top Publications Citing Use of Products

View All HSP Isoform Specific Products:

View All Isoforms
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

View All Estrogen Receptor/ERR Isoform Specific Products:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mequinol (4-Methoxyphenol)yes MercurialisOne of the bioactive ingredients, mainly used for skin discoloration[1]. MequinolIs an antioxidant that has additive/synergistic effects on carcinogenesis when combined with other phenolic antioxidants. Mequinolalso promote hERαDependent chaperone production with potential estrogenic activity[1][2][3].

IC50 & Target

HSP27, GRP94, GRP78[2]
In Vitro

Mequinol (1-10 μM; 48 h) ignificantly increases the protein levels of HSP27, GRP94, and GRP78/BiPs in HEGO13 and V2 cell[2].
Mequinol acts function in a hERα-dependent manner and has potential estrogenic activity[2]/s.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mequinol Related Antibodies

Western Blot Analysis[2]

Cell Line: HEGO13 and V2 cells with hERa expression
Concentration: 1, 10, 100 μM
Incubation Time: 48 h
Result: Significantly increased the protein levels of HSP27, GRP94, and GRP78/BiP at 1 and 10 μM, but not at 100 μM.
Molecular Weight

124.14

Formula

C7H8O2
CAS No.
Appearance

Solid

Color

White to light brown

SMILES

OC(C=C1)=CC=C1OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (805.54 mM)

DMSO : ≥ 100 mg/mL (805.54 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.0554 mL 40.2771 mL 80.5542 mL
5 mM 1.6111 mL 8.0554 mL 16.1108 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (20.14 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (20.14 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.98%

COA (246 KB) HNMR (127 KB) GC (190 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 8.0554 mL 40.2771 mL 80.5542 mL 201.3855 mL
5 mM 1.6111 mL 8.0554 mL 16.1108 mL 40.2771 mL
10 mM 0.8055 mL 4.0277 mL 8.0554 mL 20.1386 mL
15 mM 0.5370 mL 2.6851 mL 5.3703 mL 13.4257 mL
20 mM 0.4028 mL 2.0139 mL 4.0277 mL 10.0693 mL
25 mM 0.3222 mL 1.6111 mL 3.2222 mL 8.0554 mL
30 mM 0.2685 mL 1.3426 mL 2.6851 mL 6.7129 mL
40 mM 0.2014 mL 1.0069 mL 2.0139 mL 5.0346 mL
50 mM 0.1611 mL 0.8055 mL 1.6111 mL 4.0277 mL
60 mM 0.1343 mL 0.6713 mL 1.3426 mL 3.3564 mL
80 mM 0.1007 mL 0.5035 mL 1.0069 mL 2.5173 mL
100 mM 0.0806 mL 0.4028 mL 0.8055 mL 2.0139 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mequinol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mequinol150-76-5p-HydroxyanisoleHSPEstrogen Receptor/ERRHeat shock proteinsMercurialisdepigmentationInhibitorinhibitorinhibit

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