2. Apoptosis
  3. Caspase Apoptosis
  4. MMPSI

MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection.

For research use only. We do not sell to patients.

MMPSI Chemical Structure

MMPSI Chemical Structure

CAS No. : 220509-74-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 285 In-stock
Solution
10 mM * 1 mL in DMSO USD 285 In-stock
Solid
1 mg USD 120 In-stock
5 mg USD 400 In-stock
10 mg USD 640 In-stock
25 mg USD 1216 In-stock
50 mg USD 1884 In-stock
100 mg USD 2920 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

MMPSI Related Antibodies

Top Publications Citing Use of Products

View All Caspase Isoform Specific Products:

View All Isoforms
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection[1].

IC50 & Target

human Caspase-3

1.7 μM (IC50)

Molecular Weight

324.35

Formula

C14H16N2O5S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1NC2=C(C=C(S(=O)(N3[C@H](COC)CCC3)=O)C=C2)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (308.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0831 mL 15.4154 mL 30.8309 mL
5 mM 0.6166 mL 3.0831 mL 6.1662 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0831 mL 15.4154 mL 30.8309 mL 77.0772 mL
5 mM 0.6166 mL 3.0831 mL 6.1662 mL 15.4154 mL
10 mM 0.3083 mL 1.5415 mL 3.0831 mL 7.7077 mL
15 mM 0.2055 mL 1.0277 mL 2.0554 mL 5.1385 mL
20 mM 0.1542 mL 0.7708 mL 1.5415 mL 3.8539 mL
25 mM 0.1233 mL 0.6166 mL 1.2332 mL 3.0831 mL
30 mM 0.1028 mL 0.5138 mL 1.0277 mL 2.5692 mL
40 mM 0.0771 mL 0.3854 mL 0.7708 mL 1.9269 mL
50 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5415 mL
60 mM 0.0514 mL 0.2569 mL 0.5138 mL 1.2846 mL
80 mM 0.0385 mL 0.1927 mL 0.3854 mL 0.9635 mL
100 mM 0.0308 mL 0.1542 mL 0.3083 mL 0.7708 mL
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MMPSI Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMPSI220509-74-0CaspaseApoptosisCardioprotectionInfarct sizeheartIschemic MyocardiumCardiomyocytesInhibitorinhibitorinhibit

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