Multi-kinase-IN-1
Multi-kinase-IN-1 (Compound 11k) is a potent kinase inhibitor with antitumor activity. Multi-kinase-IN-1 induces cell apoptosis, and can be studied for colorectal cancer.
For research use only. We do not sell to patients.
- CAS No.: 2470807-67-9
- Formula: C35H36F2N6O6S
- Molecular Weight:706.76
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Ron 0.122 μM (IC50) |
PDGFRα 0.384 μM (IC50) |
c-Src 0.421 μM (IC50) |
AXL 0.632 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
0.31 μM
Compound: 11k
|
Anticancer activity against human HT-29 cells assessed as inhibition of cell proliferation by MTT assay
Anticancer activity against human HT-29 cells assessed as inhibition of cell proliferation by MTT assay
|
[PMID: 32731184] |
Multi-kinase-IN-1 (Compound 11k) (0-5 µg/mL, 0-72 h) induces antiproliferation and cytotoxicity in a dose- and time-dependent manner in HT-29 cells, and is much less toxic to normal colorectal mucosa epithelial cells[1].
Multi-kinase-IN-1 (0-3 µg/mL, 0-72 h) induces cell apoptosis in a time- and dose-dependent manner[1].
Multi-kinase-IN-1 (0-3 µg/mL, 48 h) slightly induces cell cycle arrest in G2/M phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HT-29 (human colon cancer cell) and FHC (normal colorectal mucosa epithelial cells)
-
Concentration:0.56, 1.67, and 5 µg/mL for HT-29, 10 µg/mL for FHC
-
Incubation Time:0-72 h
-
Result:Led to significant cytotoxicity in a dose- and time-dependent manner in HT-29 cells. Showed low toxicity in FHC cells.
-
Cell Line:HT-29
-
Concentration:0.3, 1, and 3 µg/mL
-
Incubation Time:0-72 h
-
Result:Induced cell apoptosis in a time- and dose-dependent manner.
-
Cell Line:HT-29
-
Concentration:0.3, 1, and 3 µg/mL
-
Incubation Time:48 h
-
Result:Slightly induced cell cycle arrest with a G2/M percentage of 4.4% at 3.0 mg/mL compared to 0.1% DMSO (2.4%).
Chemical Information
-
CAS No. 2470807-67-9
-
Molecular Weight 706.76
-
Formula C35H36F2N6O6S
-
SMILES
O=C(N1CCC(OC2=C(OC)C=C3C(OC4=CC=C(NC(NN5C(C6=C(F)C=CC=C6F)SCC5=O)=O)C=C4)=CC=NC3=C2)CC1)NC(C)C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz