Multi-kinase-IN-1
Multi-kinase-IN-1 (Compound 11k) is a potent kinase inhibitor with antitumor activity. Multi-kinase-IN-1 induces cell apoptosis, and can be studied for colorectal cancer.
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- CAS No.: 2470807-67-9
- Formule: C35H36F2N6O6S
- Masse moléculaire:706.76
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
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Ron 0.122 μM (IC50) |
PDGFRα 0.384 μM (IC50) |
c-Src 0.421 μM (IC50) |
AXL 0.632 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| HT-29 | IC50 |
0.31 μM
Compound: 11k
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Anticancer activity against human HT-29 cells assessed as inhibition of cell proliferation by MTT assay
Anticancer activity against human HT-29 cells assessed as inhibition of cell proliferation by MTT assay
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[PMID: 32731184] |
In Vitro
Multi-kinase-IN-1 (Compound 11k) (0-5 µg/mL, 0-72 h) induces antiproliferation and cytotoxicity in a dose- and time-dependent manner in HT-29 cells, and is much less toxic to normal colorectal mucosa epithelial cells[1].
Multi-kinase-IN-1 (0-3 µg/mL, 0-72 h) induces cell apoptosis in a time- and dose-dependent manner[1].
Multi-kinase-IN-1 (0-3 µg/mL, 48 h) slightly induces cell cycle arrest in G2/M phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT-29 (human colon cancer cell) and FHC (normal colorectal mucosa epithelial cells)
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Concentration:0.56, 1.67, and 5 µg/mL for HT-29, 10 µg/mL for FHC
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Incubation Time:0-72 h
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Result:Led to significant cytotoxicity in a dose- and time-dependent manner in HT-29 cells. Showed low toxicity in FHC cells.
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Cell Line:HT-29
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Concentration:0.3, 1, and 3 µg/mL
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Incubation Time:0-72 h
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Result:Induced cell apoptosis in a time- and dose-dependent manner.
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Cell Line:HT-29
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Concentration:0.3, 1, and 3 µg/mL
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Incubation Time:48 h
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Result:Slightly induced cell cycle arrest with a G2/M percentage of 4.4% at 3.0 mg/mL compared to 0.1% DMSO (2.4%).
Chemical Information
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CAS No. 2470807-67-9
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Masse moléculaire 706.76
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Formule C35H36F2N6O6S
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SMILES
O=C(N1CCC(OC2=C(OC)C=C3C(OC4=CC=C(NC(NN5C(C6=C(F)C=CC=C6F)SCC5=O)=O)C=C4)=CC=NC3=C2)CC1)NC(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Multi-kinase-IN-1 Related Classifications
HY-146014 Related Classifications
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