Solaprubart
Based on 1 Customer Validation
Solaprubart (STAR-0310) is a fully human IgG1 subtype monoclonal antibody targeting OX40 (CD134/TNFRSF4), with a Kd of 7.2 nM. By blocking the OX40/OX40L co-stimulatory signal, Solaprubart effectively inhibits cytokine release (IFN-γ, TNF-α, IL-5, IL-13) from activated effector T cells (Th1/Th2/Th17-associated). Solaprubart can be used in research related to moderate-to-severe atopic dermatitis.
For research use only. We do not sell to patients.
- Purity: 99.59%
- CAS No.: 3057433-10-7
- Molecular Weight:145.347 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Orexin Receptor (OX Receptor) Isoforms
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Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
OX40L |
IL-13 |
IL-6 |
In Vitro
Solaprubart (0.1-1000 nM) potently inhibits the release of IFNγ, TNF-α, IL-5 and IL-13 from pre-activated human T cells, with EC50 values of 11.8, 4.2, 16.4 and 5.3 nM, respectively[1].
Solaprubart (0-100 nM) significantly reduces ADCC activity against activated human T cells and regulatory human T cells, with EC50 values of 0.1 nM and 2.31 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
Accession
Target
TNFRSF4/OX40/CD134
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IgG1-kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized OX40/TNFRSF4 Protein, Human (HEK293, HY-P78189) can bind Solaprubart, The ED50 for this effect is 19.11 ng/mL.
Chemical Information
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CAS No. 3057433-10-7
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Appearance Liquid
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Molecular Weight 145.347 kDa
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Color Colorless to light yellow
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SMILES
[Solaprubart]
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Synonyms
STAR-0310
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Solaprubart Related Classifications
HY-P992132 Related Classifications
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