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Cat. No.: HY-155397

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PRO-HD2

PRO-HD2 is a HDAC6 PROTAC degrader. PRO-HD2 exerts antiproliferative activity in leukemia cells. PRO-HD2 can be used for leukemia research.

(Pink: HDAC6 ligand (HY-175627); Blue: Cereblon ligand (HY-41547); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3126555-89-0
Formula: C₃₈H₃₉N₅O₅S
Molecular Weight:677.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

PRO-HD2 Chemical Structure

CAS No.: 3126555-89-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PRO-HD2 is a HDAC6 PROTAC degrader. PRO-HD2 exerts antiproliferative activity in leukemia cells. PRO-HD2 can be used for leukemia research^[1].
(Pink: HDAC6 ligand (HY-175627); Blue: Cereblon ligand (HY-41547); Black: linker).

IC₅₀ & Target^[1]

HDAC6

Cereblon

All PROTACs Isoforms :

All HDAC Isoforms :

In Vitro

PRO-HD2 (500 nM-5 μM; 24 h) efficiently degrades HDAC6 in A549 cells. After 24 h of incubation, almost complete depletion of HDAC6 is observed at concentrations ≥ 500 nM^[1].
PRO-HD2 (0.5-1 μM; 12-48 h) efficiently degrades HDAC6 in MCF-7, HCT-116, A549 and Jurkat cells^[1].
PRO-HD2 (48 h) inhibits the proliferation of Jurkat cells, with an IC₅₀ of 2.62 μM after 48 h of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

A549 cells (adenocarcinomic human alveolar basal epithelial cells)
Concentration:

500 nM, 1 μM, 5 μM
Incubation Time:

24 h
Result:

Nearly completely depleted HDAC6 protein.
Exhibited higher HDAC6 degradation efficiency compared to PRO-HD1 and PRO-HD3.

Chemical Information

CAS No. 3126555-89-0
Molecular Weight 677.81
Formula C₃₈H₃₉N₅O₅S
SMILES

S=C1N(CC2=CC=C(C3=CC=C(CNCCCCCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)C=C3)C=C2)C=CC=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jia Q, et al. Cell-Specific Degradation of Histone Deacetylase Using Warhead-Caged Proteolysis Targeting Chimeras. Analytical chemistry. 2023 Nov 14;95(45):16474-16480. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PRO-HD2

All PROTACs Isoforms

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PRO-HD2 Related Classifications

HY-155397 Related Classifications