1. PI3K/Akt/mTOR
    Cytoskeleton
    Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
    Apoptosis
  2. PI3K
    Akt
    Microtubule/Tubulin
    MMP
    Apoptosis
  3. PI3K/AKT-IN-2

PI3K/AKT-IN-2 

Cat. No.: HY-147768
Handling Instructions

PI3K/AKT-IN-2 (Compound 12c) is a PI3K and AKT inhibitor. PI3K/AKT-IN-2 blocks the epithelial-mesenchymal transition (EMT) and induces apoptosis. PI3K/AKT-IN-2 inhibits the polymerization of tubulin.

For research use only. We do not sell to patients.

PI3K/AKT-IN-2 Chemical Structure

PI3K/AKT-IN-2 Chemical Structure

CAS No. : 2684412-41-5

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Description

PI3K/AKT-IN-2 (Compound 12c) is a PI3K and AKT inhibitor. PI3K/AKT-IN-2 blocks the epithelial-mesenchymal transition (EMT) and induces apoptosis. PI3K/AKT-IN-2 inhibits the polymerization of tubulin[1].

IC50 & Target

MMP-2

 

In Vitro

PI3K/AKT-IN-2 (Compound 12c) shows antiproliferative activity with IC50 values of 14.84 ± 1.53, 4.79 ± 0.71, 14.34 ± 0.57, 0.89 ± 0.023, >100 and 98.75 ± 1.59 µM against H460, MCF-7, A549, HGC-27, 293 T and GES-1 cells, respectively[1].
PI3K/AKT-IN-2 suppresses the expressions/activities of matrix metalloprotease (MMP)− 2, vimentin and up-regulation E-cadherin[1].
PI3K/AKT-IN-2 induces significant up-regulation of CDK1 proteins expression with a down-regulation of cyclin B1 and Cdc25C[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

651.45

Formula

C32H27BrO10

CAS No.
SMILES

O=C(O[[email protected]@H]1[[email protected]]2([H])[[email protected]@](C(OC2)=O)([H])[[email protected]](C3=CC(OC)=C(OC)C(OC)=C3)C4=C1C=C5OCOC5=C4)/C=C/C(C6=CC=C(Br)C=C6)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
PI3K/AKT-IN-2
Cat. No.:
HY-147768
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