Piribedil maleate
Based on 1 publication(s) in Google Scholar
Piribedil maleate is a potent and orally active dopamine D2 and dopamine D3 agonist. Piribedil maleate is also a α2-adrenoceptors antagonist. Piribedil maleate can inhibit MLL1 methyltransferase activity (EC50: 0.18 μM). Piribedil maleate has the potential for the research of parkinson's disease, circulatory disorders, cancers.
For research use only. We do not sell to patients.
- CAS No.: 937719-94-3
- Formula: C20H22N4O6
- Molecular Weight:414.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Piribedil maleate
MoreAll Dopamine Receptor Isoforms
MoreAll Adrenergic Receptor Isoforms
MoreAll Histone Methyltransferase Isoforms
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Biological Activity
Chemical Information
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CAS No. 937719-94-3
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Molecular Weight 414.41
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Formula C20H22N4O6
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SMILES
O=C(/C=C\C(O)=O)O.C1(N2CCN(CC2)CC3=CC=C4OCOC4=C3)=NC=CC=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Front Chem
Terazosin Analogs Targeting Pgk1 as Neuroprotective Agents: Design, Synthesis, and Evaluation. [Abstract]2022 Jul 26:10:906974. PMID: 35958233
Purity & Documentation
References
[1]. Sweet RD, et al. Piribedil, a dopamine agonist, in Parkinson's disease. Clin Pharmacol Ther. 1974 Dec;16(6):1077-82. [Content Brief]
[2]. Gerlach M, et al. The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson's disease: differential role of α(2) adrenergic mechanisms. J Neural Transm (Vienna). 2013 Jan;120(1):31-6. [Content Brief]
[3]. Smith LA, Tet al. Repeated administration of piribedil induces less dyskinesia than L-dopa in MPTP-treated common marmosets: a behavioural and biochemical investigation. Mov Disord. 2002 Sep;17(5):887-901. [Content Brief]
[4]. Xiong Zhang, et al. Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis. Cancer Lett. 2018 Sep 1;431:150-160. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Piribedil maleate Related Classifications
HY-12707B Related Classifications
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