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Cat. No.: HY-181318

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PROTAC EZH2 Degrader-20

PROTAC EZH2 Degrader-20 (compound 54) is an EZH2-target PROTAC degrader with antiproliferative activity and IC₅₀ values of about 10 μM against lymphoma cells. PROTAC EZH2 Degrader-20 can be used for the research of lymphoma.
(Pink: EZH2 ligand (HY-147230); Blue: cIAP ligand (HY-137159); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3093642-35-1
Formula: C₅₈H₇₆N₁₀O₉
Molecular Weight:1057.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC EZH2 Degrader-20 Chemical Structure

CAS No.: 3093642-35-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

PROTAC EZH2 Degrader-20 (compound 54) is an EZH2-target PROTAC degrader with antiproliferative activity and IC₅₀ values of about 10 μM against lymphoma cells. PROTAC EZH2 Degrader-20 can be used for the research of lymphoma^[1]. (Pink: EZH2 ligand (HY-147230); Blue: cIAP ligand (HY-137159); Black: linker).

All PROTACs Isoforms :

All Histone Methyltransferase Isoforms :

In Vitro

PROTAC EZH2 Degrader-20 (compound 54) inhibits proliferation of SU-DHL-6 and HBL-1 diffuse large B-cell lymphoma cells, with IC₅₀ values of 10.38 μM and 10.26 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3093642-35-1
Molecular Weight 1057.29
Formula C₅₈H₇₆N₁₀O₉
SMILES

CCN(C1=CC(C2=CC=C(CN3CCN(C(CCC4=CN(CC(N[C@H](CC5=CC=CC=C5)[C@@H](C(N[C@H](C(OC)=O)CC(C)C)=O)O)=O)N=N4)=O)CC3)C=C2)=CC(C(NCC6=C(C)C=C(C)NC6=O)=O)=C1C)C7CCOCC7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. S Abulkhair H, et al. Therapeutic horizons in the development of PROTAC-based EZH2 inhibitors: recent achievements, comparative analysis, and future perspectives. RSC Adv. 2026;16(4):3034-3056. Published 2026 Jan 14. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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PROTAC EZH2 Degrader-20

All PROTACs Isoforms

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC EZH2 Degrader-20 Related Classifications

HY-181318 Related Classifications