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Cat. No.: HY-181332

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PROTAC EZH2 Degrader-37

PROTAC EZH2 Degrader-37 (compound 16) is a PROTAC protein degrader targeting EZH2 with a target IC₅₀ of 144 nM. PROTAC EZH2 Degrader-37 is applicable to lymphoma-related research.
(Pink: EZH2 ligand (HY-147230); Blue: Cereblon ligand (HY-103596); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 2653338-73-7
Formula: C₅₇H₇₃N₇O₈
Molecular Weight:984.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC EZH2 Degrader-37 Chemical Structure

CAS No.: 2653338-73-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

PROTAC EZH2 Degrader-37 (compound 16) is a PROTAC protein degrader targeting EZH2 with a target IC₅₀ of 144 nM. PROTAC EZH2 Degrader-37 is applicable to lymphoma-related research^[1]. (Pink: EZH2 ligand (HY-147230); Blue: Cereblon ligand (HY-103596); Black: linker).

All PROTACs Isoforms :

All Histone Methyltransferase Isoforms :

In Vitro

PROTAC EZH2 Degrader-37 (compound 16) inhibits EZH2 enzymatic activity with an IC₅₀ of 144.00 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2653338-73-7
Molecular Weight 984.23
Formula C₅₇H₇₃N₇O₈
SMILES

CCN(C1CCOCC1)C2=CC(C3=CC=C(C=C3)CN4CCN(CC4)CCCCCCCCCCOC5=C(C6=CC=C5)C(N(C6=O)C7CCC(NC7=O)=O)=O)=CC(C(NCC8=C(C=C(NC8=O)C)C)=O)=C2C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. S Abulkhair H, et al. Therapeutic horizons in the development of PROTAC-based EZH2 inhibitors: recent achievements, comparative analysis, and future perspectives. RSC Adv. 2026;16(4):3034-3056. Published 2026 Jan 14. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
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References

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PROTAC EZH2 Degrader-37

All PROTACs Isoforms

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC EZH2 Degrader-37 Related Classifications

HY-181332 Related Classifications