PROTAC EZH2 Degrader-42
PROTAC EZH2 Degrader-42 (compound 57) is an EZH2-targeting PROTAC degrader and antiproliferative agent. PROTAC EZH2 Degrader-42 induces cIAP-mediated ubiquitination and subsequent proteasomal degradation of EZH2. PROTAC EZH2 Degrader-42 can be used for the research of lymphoma.
(Pink: EZH2 ligand (HY-147230); Blue: cIAP ligand (HY-137159); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 3093642-42-0
- Formula: C65H93N11O11
- Molecular Weight:1204.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PROTAC EZH2 Degrader-42 (compound 57) (10.00-30.00 μM) degrades EZH2 in SU-DHL-6 cells at 10.00 μM and 30.00 μM, and exhibits cytotoxic activity against SU-DHL-6 (IC50 = 10.22 μM) and HBL-1 (IC50 = 10.17 μM) diffuse large B-cell lymphoma cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3093642-42-0
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Molecular Weight 1204.50
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Formula C65H93N11O11
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SMILES
CCN(C1CCOCC1)C2=CC(C3=CC=C(C=C3)CN4CCN(CC4)C(CCC5=CN(N=N5)CCOCCOCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@H](N)CC6=CC=CC=C6)=O)=O)=O)=CC(C(NCC7=C(C=C(NC7=O)C)C)=O)=C2C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC EZH2 Degrader-42 Related Classifications
HY-181411 Related Classifications
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