Ribociclib-d6 hydrochloride
Based on 1 Customer Validation
Ribociclib-d6 (LEE011-d6) hydrochloride is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
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- Pureté : 98.26%
- CAS No.: 2934109-69-8
- Formule: C23H25D6ClN8O
- Masse moléculaire:477.04
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2934109-69-8
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Unlabeled CAS 1211443-80-9
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Appearance Solid
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Masse moléculaire 477.04
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Formule C23H25D6ClN8O
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Color Light yellow to light brown
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SMILES
O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C([2H])([2H])[2H])C([2H])([2H])[2H].Cl
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Synonyms
LEE011-d6 hydrochloride
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (209.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
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Fiche technique (271 KB)
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SDS (789 KB)
- English - EN (789 KB)
- Français - FR (789 KB)
- Deutsch - DE (789 KB)
- Norwegian - NO (789 KB)
- Español - ES (789 KB)
- Swedish - SV (789 KB)
- Italian - IT (789 KB)
- Korean - KR (789 KB)
- Portuguese - PT (789 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0963 mL | 10.4813 mL | 20.9626 mL | 52.4065 mL |
| 5 mM | 0.4193 mL | 2.0963 mL | 4.1925 mL | 10.4813 mL | |
| 10 mM | 0.2096 mL | 1.0481 mL | 2.0963 mL | 5.2407 mL | |
| 15 mM | 0.1398 mL | 0.6988 mL | 1.3975 mL | 3.4938 mL | |
| 20 mM | 0.1048 mL | 0.5241 mL | 1.0481 mL | 2.6203 mL | |
| 25 mM | 0.0839 mL | 0.4193 mL | 0.8385 mL | 2.0963 mL | |
| 30 mM | 0.0699 mL | 0.3494 mL | 0.6988 mL | 1.7469 mL | |
| 40 mM | 0.0524 mL | 0.2620 mL | 0.5241 mL | 1.3102 mL | |
| 50 mM | 0.0419 mL | 0.2096 mL | 0.4193 mL | 1.0481 mL | |
| 60 mM | 0.0349 mL | 0.1747 mL | 0.3494 mL | 0.8734 mL | |
| 80 mM | 0.0262 mL | 0.1310 mL | 0.2620 mL | 0.6551 mL | |
| 100 mM | 0.0210 mL | 0.1048 mL | 0.2096 mL | 0.5241 mL |
Ribociclib-d6 hydrochloride Related Classifications
HY-15777AS Related Classifications
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