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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2087 Results for "
Probe L
" in MedChemExpress (MCE) Product Catalog:
Products (2087)
2087 Results for "Probe L" in MCE Product Catalog:
Cat. No.: HY-D3082
CAS No.: 2222720-58-1
Target:
Research Areas:
Probe L is an AIE-based dual-sensing fluorescent probe for the detection of Zn 2+ and single-stranded DNA (ssDNA). Coordination of Probe L with Zn 2+ restricts intramolecular rotation and triggers ESIPT, turning on fluorescence at 490 nm. Upon further binding of the Probe L-Zn 2+ complex to ssDNA, enhanced emission is generated at 550 nm. Ex/Em = 365/490 nm (Zn 2+); Ex/Em = 365/550 nm (ssDNA) .
846
331
331 Cited Publications
Cat. No.: HY-D1055
CAS No.: 1003197-00-9
Excitation/emission wavelength: 510/580 nm.
310
Research Areas:
(+)-JQ-1 (JQ1), a chemical probe, is a potent, specific, CNS-penetrant and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)) . (+)-JQ-1 also activates autophagy .
247
115
115 Cited Publications
Research Areas:
A-485, a chemical probe, is a potent and selective catalytic inhibitor of p300/CBP with IC50s of 9.8 nM and 2.6 nM for p300 and CBP histone acetyltransferase (HAT), respectively .
100
100 Cited Publications
Cat. No.: HY-128868
CAS No.: 60842-46-8
100
100 Cited Publications
Cat. No.: HY-128868A
CAS No.: 60842-46-8
87
87 Cited Publications
Cat. No.: HY-D0985A
CAS No.: 115532-52-0
Synonyms: Tetramethylrhodamine ethyl ester perchlorate
84
84 Cited Publications
Target:
Research Areas:
2-NBDG is a fluorescently-labeled deoxyglucose analog that is used primarily to directly monitor glucose uptake by living cells and tissues. It is also used as a topical contrast reagent for the detection of neoplasia. 2-NBDG can be used in real-time confocal, high-resolution, or wide-field fluorescence microscopy as well as in flow cytometry. The probe can be excited by the Argon laser at 488 nm to give the environment-sensitive fluorescence. It has lower photostability than the rhodamine-based fluorescent probes.
60
60 Cited Publications
Target:
Research Areas:
BAY-876, a chemical probe, is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis .
49
49 Cited Publications
Cat. No.: HY-D1533
CAS No.: 1447815-38-4
44
42
42 Cited Publications
Cat. No.: HY-D0989
CAS No.: 145037-81-6
41
41 Cited Publications
NVP-2 is a potent and selective ATP-competitive cyclin dependent kinase 9 (CDK9) probe, inhibits CDK9/CycT activity with an IC50 of 0.514 nM. NVP-2 displays inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases with IC50 values of 0.584 μM, 0.706 μM, and 0.605 μM, respectively. NVP-2 induces cell apoptosis.
37
37 Cited Publications
36
36 Cited Publications
Cat. No.: HY-D1913
33
33 Cited Publications
Target:
Research Areas:
GSK343, a chemical probe, is a highly potent and selective EZH2 inhibitor with an IC50 of 4 nM.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
