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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
759 Results for "
Epithelial
" in MedChemExpress (MCE) Product Catalog:
Products (759)
759 Results for "Epithelial" in MCE Product Catalog:
6
6 Cited Publications
Synonyms: p-Tolyl sulfate
Target:
6
Category:
Flavonols Flavonoids Monophenols Phenols Epimedium brevicornu Maxim. Plants Disease Research Fields Inflammation/Immunology Berberidaceae Extract
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5
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R(+)-Methylindazone (R(+)-IAA-94) is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-Methylindazone inhibits Nef-sdAb19 (single-domain antibody) interaction and binds to negative factor (Nef) .
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5
5 Cited Publications
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ZINC40099027 is a selective FAK activator. ZINC40099027 promotes FAK phosphorylation, without activating its paralogs Pyk2 and Src. ZINC40099027 promotes the wound closure of human intestinal epithelial monolayers and the healing of mouse ulcers by activating FAK. ZINC40099027 can be used for diseases related to gastrointestinal mucosal injury research .
5
5 Cited Publications
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LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding .
LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells .
4
4 Cited Publications
Synonyms: Boc-Met-Leu-Phe-OH
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Boc-MLF (Boc-Met-Leu-Phe-OH) is a competitive FPR1 antagonist. Boc-MLF inhibits fMLF-induced neutrophil activation through FPR. Boc-MLF inhibits receptor-induced inflammation and cell migration. Boc-MLF inhibits amniotic epithelial-mesenchymal transition. Boc-MLF reduces pro-inflammatory cytokine levels. Boc-MLF increases collagen expression in fetal membranes. Boc-MLF reverses fetal membrane epithelial cell collapse, increases villi, and reduces mucus attachment. Boc-MLF can be used in research on premature rupture of fetal membranes .
4
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Boc-MLF TFA (Boc-Met-Leu-Phe-OH TFA) is a competitive FPR1 antagonist. Boc-MLF TFA inhibits fMLF-induced neutrophil activation through FPR. Boc-MLF TFA inhibits receptor-induced inflammation and cell migration. Boc-MLF TFA inhibits amniotic epithelial-mesenchymal transition. Boc-MLF TFA reduces pro-inflammatory cytokine levels. Boc-MLF TFA increases collagen expression in fetal membranes. Boc-MLF TFA reverses fetal membrane epithelial cell collapse, increases villi, and reduces mucus attachment. Boc-MLF TFA can be used in research on premature rupture of fetal membranes .
4
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4
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Seeds of Cassia tora Linn. Leguminosae Extract Plants Other Families Extract Quinones Anthraquinones Phenols Polyphenols Disease Research Fields Cancer
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4
4 Cited Publications
Synonyms: 5'-Uridylic acid
4
4 Cited Publications
Cat. No.: HY-W013175
CAS No.: 3387-36-8
Synonyms: 5'-Uridylic acid disodium salt
4
Category:
Plants Endogenous metabolite Indole Alkaloids Alkaloids Human Gut Microbiota Metabolites Microorganisms Other Diseases Isatis tinctoria L. Cruciferae Extract Disease Research Fields
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4
3
3 Cited Publications
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ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 hydrochloride reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 hydrochloride also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 hydrochloride can be used in the study of endometriosis and liver fibrosis .
3
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CPA inhibitor (Compound 5) (Carboxypeptidase inhibitor) is an orally active competitive carboxypeptidase A (CPA) inhibitor with a Ki value of 0.32 μM. CPA inhibitor blocks the activity of carboxypeptidase A3 (CPA3). CPA activator activates the Wnt/Lrp6/β-catenin signaling pathway. CPA inhibitor reduces epithelial damage. CPA inhibitor is applicable to research related to inflammatory bowel disease, including ulcerative colitis and Crohn's disease .
3
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Ospemifene (FC-1271a) is an orally active and non-estrogenic selective estrogen receptor modulator (SERM) with Ki values of 380 and 410 nM for estrogen receptor α (ERα) and ERβ, respectively. Ospemifene inhibits caspase-3 activity. Ospemifene inhibits neuronal degeneration, prevents bone loss, and increases vaginal weight and vaginal epithelial height. Ospemifene has anticancer activity against breast cancer .
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3
3 Cited Publications
Synonyms: Tris; Tris(hydroxymethyl)aminomethane
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THAM (Tris) is a low-toxicity amino alcohol buffer, a specific CO2-consuming proton acceptor that buffers carbon dioxide and acid both in vitro and in vivo. THAM binds protons to form bicarbonate, reduces PaCO2, and induces intracellular alkalization, thereby ameliorating hypercapnia-induced elevation of pulmonary blood vessels and pulmonary arterial pressure. THAM may cause PaCO2 rebound, hypoglycemia, and respiratory depression. THAM removes amniotic epithelium and preserves the basement membrane, but depletes extracellular matrix and reduces the adhesion rate of limbal epithelial cells. THAM can act as a CO2 carrier to enhance the productivity and carbon utilization rate of Scenedesmus obliquus. THAM is a key component of buffer solutions used in various biological, cell culture, biochemical, and molecular biology applications .
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3 Cited Publications
Cat. No.: HY-N4185
CAS No.: 61153-77-3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
