189 Results for "

PI3K/AKT/mTOR

" in MedChemExpress (MCE) Product Catalog:
Products (189)

189 Results for "PI3K/AKT/mTOR" in MCE Product Catalog:

4
Flavokawain C
Flavokawain C
0 Images
4 Cited Publications
Cat. No.: HY-N2445
CAS No.: 37308-75-1
Category:  

Piperaceae Extract Plants Other Families Extract Flavonoids Chalcones Piper methysticum G.Forst. Phenols Polyphenols Disease Research Fields Cancer

Target:  

Apoptosis Akt JNK PERK Caspase PARP MDM-2/p53 IAP Reactive Oxygen Species (ROS) SOD FABP Autophagy AMPK mTOR GLUT EGFR PI3K HSP VEGFR FAK

Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces apoptosis. Flavokawain C downregulates FABP4, induces autophagy in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer .
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Typhaneoside
Typhaneoside
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4 Cited Publications
Cat. No.: HY-N0712
CAS No.: 104472-68-6
Category:  

Cardiovascular Disease Flavonols Flavonoids Typhaceae Extract Typha angustifolia L. Phenols Polyphenols Plants Disease Research Fields

Target:  

mTOR Akt FXR PI3K Autophagy Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Calcium Channel

Typhaneoside is an orally active activator of PI3K/Akt/mTOR and farnesoid X receptor. Typhaneoside promotes the activation of AMPK and Caspase-3, induces apoptosis, ferroptosis, autophagy, ROS accumulation, cell cycle arrest at the G2/M phase, and reduces cancer cell viability. Typhaneoside improves glucose and lipid metabolism, alleviates inflammatory responses, oxidative stress and hepatic lipid accumulation, and exerts hepatoprotective effects. Typhaneoside can be used in research related to heart failure after myocardial infarction, acute myeloid leukemia, non-alcoholic fatty liver disease and neurological disorders .
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Tegaserod
Tegaserod
0 Images
4 Cited Publications
Cat. No.: HY-14153
CAS No.: 145158-71-0
Purity:  99.89%
Target:  

5-HT Receptor Apoptosis

Research Areas:  

Metabolic Disease Cancer

Tegaserod is an orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist and a 5-HT2B receptor antagonist. Tegaserod has pKis of 7.5, 8.4 and 7.0 for human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research .
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Tegaserod maleate
Tegaserod maleate
0 Images
4 Cited Publications
Cat. No.: HY-14153A
CAS No.: 189188-57-6
Purity:  99.90%
Synonyms: SDZ-HTF-919; HTF-919
Target:  

5-HT Receptor Apoptosis

Research Areas:  

Neurological Disease Metabolic Disease Cancer

Tegaserod maleate (SDZ-HTF-919) is an orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist and a 5-HT2B receptor antagonist. Tegaserod maleate has pKis of 7.5, 8.4 and 7.0 for human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. Tegaserod maleate causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod maleate has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research .
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3
Izorlisib
Izorlisib
0 Images
3 Cited Publications
Cat. No.: HY-15466
CAS No.: 1007207-67-1
Purity:  99.01%
Synonyms: CH5132799
Target:  

PI3K Apoptosis mTOR Akt

Research Areas:  

Cancer

Izorlisib (CH5132799) is an orally active, selective Class I PI3K inhibitor with an IC50 value of 14 nM against PI3Kα. Izorlisib specifically inhibits Class I PI3K (particularly PI3Kα and its mutants) and blocks the PI3K/Akt/mTOR pathway; this leads to cell cycle arrest at the G1 phase and apoptosis without triggering feedback activation of Akt by competitively binding to the ATP-binding site of PI3K. Izorlisib can be used in research on cancers harboring PIK3CA mutations or PTEN loss (such as breast, ovarian, prostate, and endometrial cancers) .
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2
Lipoteichoic acid
Lipoteichoic acid
0 Images
2 Cited Publications
Cat. No.: HY-N9481
CAS No.: 56411-57-5
Category:  

Natural Products Microorganisms Disease Research Fields Inflammation/Immunology

Target:  

Complement System Autophagy mTOR Akt PI3K ERK Interleukin Related

Lipoteichoic acid is an orally effect anti-inflammatory and antitumor agent. Lipoteichoic acid is a crucial immune molecule in Gram-positive bacteria that activates the complement system by inducing C3 and inhibiting CD55. Lipoteichoic acid regulates macrophage autophagy through the PI3K/Akt/mTOR pathway. Lipoteichoic acid induces lung damage in mice. Lipoteichoic acid inhibits the production of melanin .
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2
Hederacolchiside A1
Hederacolchiside A1
0 Images
2 Cited Publications
Cat. No.: HY-N6950
CAS No.: 106577-39-3
Category:  

Infection Triterpenes Terpenoids Plants Other Families Extract Disease Research Fields

Target:  

PI3K Akt mTOR Parasite Apoptosis

Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway . Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro .
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Amarogentin
Amarogentin
0 Images
2 Cited Publications
Cat. No.: HY-N2447
CAS No.: 21018-84-8
Category:  

Gentiana scabra Bunge Iridoids Terpenoids Metabolic Disease Gentianaceae Extract Phenols Polyphenols Plants Disease Research Fields

Target:  

AMPK Apoptosis

Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK .
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2
PI3K/mTOR Inhibitor-11
PI3K/mTOR Inhibitor-11
0 Images
2 Cited Publications
Cat. No.: HY-151622
CAS No.: 2845104-25-6
Purity:  98.74%
Target:  

PI3K mTOR

Research Areas:  

Cancer

PI3K/mTOR Inhibitor-11 is an orally active PI3K/mTOR inhibitor (IC50: 3.5, 4.6, and 21.3 nM for PI3Kα, PI3Kδ, and mTOR). PI3K/mTOR Inhibitor-11 regulates the PI3K/AKT/mTOR signaling pathway by inhibiting the phosphorylation of AKT and S6 proteins. PI3K/mTOR Inhibitor-11 can be used in the research of cancers .
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2
Bellidifolin
Bellidifolin
0 Images
2 Cited Publications
Cat. No.: HY-N2000
CAS No.: 2798-25-6
Category:  

Infection Xanthones Swertia bimaculata (Sieb. et Zucc.) Hook. f. et Thoms. ex C. B. Clark Gentianaceae Extract Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

STAT PI3K mTOR Akt

Bellidifolin is an orally active compound with antiproliferative, anti-inflammatory and antioxidant properties. Bellidifolin modulates key signaling pathways including STAT3, PI3K-Akt, mTOR and BRD4, and inhibits the viral protein R (Vpr). Bellidifolin induces cell cycle arrest and apoptosis, exerts significant antifibrotic effects, and protects the heart, liver and nervous system. Bellidifolin is applicable to the research of various diseases such as lung cancer, non-alcoholic fatty liver disease, myocardial hypertrophy and ischemic cranial nerve injury .
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2
Brassinin
Brassinin
0 Images
2 Cited Publications
Cat. No.: HY-111334
CAS No.: 105748-59-2
Purity:  99.74%
Synonyms: Brassinine
Category:  

Beassica pekinensis (Lour. ) Rupr. Alkaloids Cruciferae Extract Cosmetic Research Plants Disease Research Fields Cancer Indole Alkaloids

Target:  

Endogenous Metabolite Indoleamine 2,3-Dioxygenase (IDO) Apoptosis Autophagy Paraptosis Reactive Oxygen Species (ROS) Tie Akt PERK PI3K mTOR Ribosomal S6 Kinase (RSK)

Brassinin is an indole derivative found in cruciferous plants. Brassinin acts as an IDO inhibitor (Ki = 97.7 μM). Brassinin inhibits angiogenesis and induces apoptosis, autophagy, paraptosis, ROS production, and ER stress. Brassinin selectively stimulates lysosomal degradation of Tie2 and promotes lysosomal and proteasomal degradation of FGFR1 in endothelial cells, downregulating AKT and ERK phosphorylation. Brassinin inhibits endothelial cell proliferation, migration, tube formation, spheroid sprouting, and angiogenesis. Brassinin inhibits PI3K/Akt/mTOR/S6K1 signaling, upregulates p21 and p27, and induces G1 phase cell cycle arrest through RB hypophosphorylation. Brassinin inhibits tyrosinase catalytic activity, reduces tyrosinase mRNA, and inhibits MITF nuclear translocation. Brassinin is used for research on triple-negative breast cancer, chronic myeloid leukemia, colon cancer, glioma, atherosclerosis, and skin cancer .
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Phellodendrine chloride
Phellodendrine chloride
0 Images
2 Cited Publications
Cat. No.: HY-N0735
CAS No.: 104112-82-5
Category:  

Rutaceae Extract Alkaloids Phellodendron amurense Rupr. Phenols Polyphenols Plants Disease Research Fields Isoquinoline Alkaloids Cancer

Target:  

Autophagy Apoptosis AMPK mTOR STAT Interleukin Related PKC p38 MAPK NF-κB COX Reactive Oxygen Species (ROS) PI3K Akt MMP

Phellodendrine chloride is an orally active plant alkaloid. Phellodendrine chloride inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine chloride promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine chloride can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine chloride suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine chloride inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine chloride has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway .
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Pectolinarigenin
Pectolinarigenin
0 Images
2 Cited Publications
Cat. No.: HY-N0493
CAS No.: 520-12-7
Category:  

Flavonoids Flavones Campylotropis hirtella (Franch.) Schindl. Phenols Polyphenols Plants Compositae Extract Disease Research Fields Inflammation/Immunology

Target:  

COX Lipoxygenase NF-κB p38 MAPK ERK HIF/HIF Prolyl-Hydroxylase Keap1-Nrf2 PI3K Apoptosis Autophagy

Pectolinarigenin is an orally active dual inhibitor of COX-2/5-LOX with anti-inflammatory, antioxidant, antitumor and neuroprotective activities. Pectolinarigenin exerts neuroprotective and anti-inflammatory effects on astrocyte inflammation via the NFκB and MAPK pathways. Pectolinarigenin inhibits LPS-induced phosphorylation of ERK1/2, N-FκB and p38MAPK, directly inhibits the enzymatic activity or binding of COX-2, 5-LOX and HIF-1α, and reduces the level of XIAP. Pectolinarigenin modifies Keap1 to promote nuclear accumulation of Nrf2, induces ARE-mediated antioxidant enzyme expression, and possesses direct free radical scavenging activity. Pectolinarigenin reduces the release of NO, proinflammatory mediators and leukotrienes, and increases the level of IL-10. Pectolinarigenin induces G2/M cell cycle arrest, apoptosis (Apoptosis) and autophagy (Autophagy) via the PI3K/AKT/mTOR signaling pathway. Pectolinarigenin reduces renal crystal deposition and inhibits melanin synthesis. Pectolinarigenin inhibits inflammation and alleviates allergy in mouse models of inflammation. Pectolinarigenin alleviates renal injury, inflammation and oxidative stress in mice by inhibiting HIF-1α activity. Pectolinarigenin can be used for the research of neurodegenerative diseases, inflammatory/allergic diseases, calcium oxalate nephrocalcinosis, gastric cancer, melasma, post-inflammatory diseases and chloasma .
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Licoricesaponin G2
Licoricesaponin G2
0 Images
1 Cited Publications
Cat. No.: HY-N6983
CAS No.: 118441-84-2
Category:  

Other Terpenoids Terpenoids Leguminosae Extract Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer

Target:  

TNF Receptor PI3K Akt mTOR Reactive Oxygen Species (ROS)

Licoricesaponin G2 is an orally active component found in Licorice. Licoricesaponin G2 significantly ameliorates Bleomycin (HY-108345)-induced pulmonary fibrosis by inhibiting the TNF-α signaling pathway, reducing epithelial-mesenchymal transition, and decreasing extracellular matrix deposition. Licoricesaponin G2 inhibits cancer cells proliferation, migration, inhibits PI3K/AKT/mTOR signaling pathway and increases ROS production. Licoricesaponin G2 can be used for the research of lung cancer and pulmonary fibrosis .
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ARI-1
ARI-1
0 Images
1 Cited Publications
Cat. No.: HY-139534
CAS No.: 3078120-01-8
Purity:  99.16%
Target:  

ROR Apoptosis Akt mTOR PARP

Research Areas:  

Cancer

ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor. ARI-1 blocks the PI3K/AKT/mTOR signaling pathway in a ROR1-dependent manner. ARI-1 upregulates cleaved-PARP and p-P38. ARI-1 induces Apoptosis. ARI-1 has anticancer activity against non-small cell lung cancer .
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Isoviolanthin
Isoviolanthin
0 Images
1 Cited Publications
Cat. No.: HY-N6896
CAS No.: 40788-84-9
Category:  

Flavonoids Flavones Phenols Polyphenols Plants Other Families Extract Disease Research Fields Cancer

Target:  

TGF-beta/Smad PI3K Akt mTOR MMP Histone Demethylase

Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2 and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma .
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Raddeanin A
Raddeanin A
0 Images
1 Cited Publications
Cat. No.: HY-N0819
CAS No.: 89412-79-3
Category:  

Triterpenes Terpenoids Plants Other Families Extract Disease Research Fields Cancer

Target:  

Apoptosis PI3K Akt ERK mTOR Wnt β-catenin Wee1 JNK VEGFR CDK

Raddeanin A is an oleanane-type triterpenoid saponin with oral activity. Raddeanin A inhibits SRC, mTOR, JNK, VEGFR2, NLRP3 inflammasome, Wnt/β-catenin, Wee1, PI3K/AKT signaling pathway, MAPK/ERK signaling pathway, AR-FL, AR-Vs, and downregulates the expression of p-PI3K and p-AKT. Raddeanin A inhibits osteoclast formation, bone resorption, osteolysis, cancer cell invasion, migration, proliferation, angiogenesis and epithelial-mesenchymal transition, while induces apoptosis, cell cycle arrest, ROS production, immunogenic cell death and dendritic cell maturation. Raddeanin A improves blood-retinal barrier function, alleviates inflammation, regulates the tumor microenvironment, and enhances the activity of anti-PD-1 antibody. Raddeanin A is applicable to the research of breast cancer-associated osteolysis, human osteosarcoma, colorectal cancer, glioblastoma, Alzheimer's disease, cholangiocarcinoma, melanoma, non-small cell lung cancer, castration-resistant prostate cancer and multiple myeloma .
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Curzerenone
Curzerenone
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1 Cited Publications
Cat. No.: HY-N3651
CAS No.: 20493-56-5
Category:  

Infection Zingiberaceae Extract Terpenoids Sesquiterpenes Plants Curcuma phaeocaulis Valeton Disease Research Fields

Target:  

Bacterial Reactive Oxygen Species (ROS) Apoptosis PI3K Akt mTOR

Curzerenone is an orally active sesquiterpene compound and Antibacterial agent. Curzerenone can be isolated from Curcuma zedoaria and Curcuma aeruginosa plants. Curzerenone increases ROS levels, activates Apoptotic signaling pathways, and attenuates the PI3K/AKT/mTOR signaling pathway. Curzerenone exhibits anticancer activity against liver cancer and cervical cancer. Curzerenone has antioxidant effects. Curzerenone shows weak antibacterial activity against Escherichia coli. Curzerenone can be used in research related to hepatocellular carcinoma, cervical cancer, and Escherichia coli infection .
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Voacamine
Voacamine
0 Images
1 Cited Publications
Cat. No.: HY-N6932
CAS No.: 3371-85-5
Category:  

Alkaloids Metabolic Disease Plants Other Families Extract Disease Research Fields Indole Alkaloids

Target:  

Cannabinoid Receptor P-glycoprotein PI3K Akt mTOR Apoptosis Autophagy EGFR

Voacamine is an indole alkaloid with cannabinoid 1 (CB1) antagonistic activity. Voacamine can inhibit nuclear translocation. Voacamine is effective in enhancing the effect of Doxorubicin (HY-15142A) as it interferes with the P-glycoprotein (P-gp) function. Voacamine promotes apoptosis-independent autophagic cell death in human osteosarcoma cells. Voacamine activates mitochondrial-associated apoptosis signaling pathway and inhibition of PI3K/Akt/mTOR signaling pathway to suppress breast cancer progression. Voacamine inhibits EGFR to exert oncogenic activity against colorectal cancer .
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Rhodiolin
Rhodiolin
0 Images
1 Cited Publications
Cat. No.: HY-N6841
CAS No.: 86831-53-0
Category:  

Flavonols Flavonoids Rhodiola rosea Linn. Other Diseases Phenols Polyphenols Crassulaceae Extract Plants Disease Research Fields

Target:  

Glucose-6-Phosphate Isomerase (GPI) Casein Kinase Virus Protease Flavivirus PI3K Akt mTOR Apoptosis

Rhodiolin, a flavonoid, is an orally active glucose 6-phosphate isomerase (GPI) inhibitor. Rhodiolin inhibits papillary thyroid cancer (PTC) by targeting glycolysis enzyme glucose 6-phosphate isomerase GPI and suppressing PI3K/AKT/mTOR phosphorylation and induce apoptosis. Rhodiolin as a NS2B-NS3 protease inhibitor can disrupt dengue viral replication. Rhodiolin is also a potential candidate for developing anticancer strategies inhibiting CK1ε kinase. Rhodiolin can be used for the study of anti-tumor and anti-viral .
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