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Results for "

AC

" in MedChemExpress (MCE) Product Catalog:

969

Inhibitors & Agonists

26

Fluorescent Dye

25

Biochemical Assay Reagents

573

Peptides

1

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7

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44

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Products

10

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27

Isotope-Labeled Compounds

46

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21

Click Chemistry

66

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1

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1098
    Ac2-26
    5+ Cited Publications

    		 Annexin A NF-κB Inflammation/Immunology
    Ac2-26 is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ameliorates lung ischemia-reperfusion injury. Ac2-26 also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .
    Ac2-26
  • HY-P1393
    AC 187

    		Amylin Receptor Endocrinology
    AC 187 is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 has neuroprotective effects .
    AC 187
  • HY-P10149
    Ac-IEPD-CHO
    1 Publications Verification

    		 Caspase Cancer
    Ac-IEPD-CHO is a reversible granzyme B inhibitor with a Ki of 80 nM . Ac-IEPD-CHO is also a caspase-8 inhibitor .
    Ac-IEPD-CHO
  • HY-P11212
    Ac-RHKK(Ac)-AMC

    		Fluorescent Dye Metabolic Disease Cancer
    Ac-RHKK(Ac)-AMC (Compound S1) is a fluorescent substrate for SITR6, that is based on p53 sequence. Ac-RHKK(Ac)-AMC mimics H3K56 deacetylation site and significantly increases the deacetylation signal with low signal-to-background ratio. Ac-RHKK(Ac)-AMC can be used for ageing and cancers research .
    Ac-RHKK(Ac)-AMC
  • HY-P1098A
    Ac2-26 TFA
    5+ Cited Publications

    		 Annexin A NF-κB Inflammation/Immunology
    Ac2-26 TFA is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ameliorates lung ischemia-reperfusion injury. Ac2-26 also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .
    Ac2-26 TFA
  • HY-P4547
    Ac-Trp-Glu-His-Asp-AMC

    AC-WEHD-AMC

    		 Caspase Others
    Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .
    Ac-Trp-Glu-His-Asp-AMC
  • HY-P2717
    Ac-YVAD-AMC

    		Caspase Infection
    Ac-YVAD-AMC is an inhibitor for caspase. Ac-YVAD-AMC inhibits bacteria-induced cell death of hypersensitive response (HR) cells .
    Ac-YVAD-AMC
  • HY-135070
    Ac-RLR-AMC

    AC-Arg-Leu-Arg-AMC

    		 Proteasome Others
    Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes .
    Ac-RLR-AMC
  • HY-P10201A
    Ac-GpYLPQTV-NH2 acetate

    		STAT Cancer
    Ac-GpYLPQTV-NH2 acetate is a STAT3 inhibitor with an IC50 value of 0.33 μM. Ac-GpYLPQTV-NH2 acetate has antitumor activity .
    Ac-GpYLPQTV-NH2 acetate
  • HY-P1393A
    AC 187 TFA

    		Amylin Receptor Endocrinology
    AC 187 TFA is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 TFA shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 TFA has neuroprotective effects .
    AC 187 TFA
  • HY-P4417
    Ac-IEPD-AMC

    		Fluorescent Dye Others
    Ac-IEPD-AMC is a fluorogenic substrate for the determination of protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
    Ac-IEPD-AMC
  • HY-170534
    Ac-EEVC-OH

    		ADC Linker Cancer
    Ac-EEVC-OH is a ADC Linker that can be used for the synthesis of ADC molecules .
    Ac-EEVC-OH
  • HY-P4846
    Ac-Pro-Gly-Pro-OH
    2 Publications Verification

    		 CXCR Apoptosis IFNAR TNF Receptor Interleukin Related Infection Inflammation/Immunology
    Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and acts as a CXCR2 agonist . Ac-Pro-Gly-Pro-OH exerts bactericidal activity by generating hydrogen peroxide, inhibits pulmonary inflammation, and reduces immune cell apoptosis (apoptosis). Ac-Pro-Gly-Pro-OH promotes the production of IFN-γ and inhibits the production of TNF-α and IL-6 in leukocytes. Ac-Pro-Gly-Pro-OH increases the survival rate of mice in sepsis models, enhances the bactericidal activity of neutrophils, acts as a neutrophil chemoattractant, induces neutrophil polarization, and regulates inflammatory and repair processes. Ac-Pro-Gly-Pro-OH induces chronic inflammation and tissue remodeling through sustained action. Ac-Pro-Gly-Pro-OH is released via alkaline hydrolysis of corneal proteins in alkali-injured eyes, thereby driving the early infiltration of neutrophils into the cornea. Ac-Pro-Gly-Pro-OH is applicable to research related to sepsis, chronic obstructive pulmonary disease, cystic fibrosis, bronchiolitis obliterans syndrome, severe asthma, idiopathic pulmonary fibrosis, and corneal ulcer .
    Ac-Pro-Gly-Pro-OH
  • HY-P10939A
    Ac-DMLD-CMK TFA

    		Caspase Pyroptosis Inflammation/Immunology Cancer
    Ac-DMLD-CMK TFA is a caspase 3 inhibitor and a GSDME inhibitor. Ac-DMLD-CMK TFA binds directly to the catalytic domain of caspase-3, blocks caspase-3-mediated cleavage of GSDME, inhibits the activation of caspase 3 and Gsdme in the caspase 3-Gsdme signaling pathway, and reduces the levels of pyroptosis and apoptosis as well as the expression of LDH, IL-6, IL-1β and IL-18. Ac-DMLD-CMK TFA alleviates renal function deterioration, renal tubular epithelial cell injury, inflammatory cytokine secretion, pulmonary structural damage, and chemotherapy-induced nephrotoxicity .
    Ac-DMLD-CMK TFA
  • HY-136727
    Ac-LEVD-CHO
    1 Publications Verification

    		 Caspase Cancer
    Ac-LEVD-CHO is a caspase-4 inhibitor. Ac-LEVD-CHO is a peptide with the sequence of Ac-Leu-Glu-Val-Asp-al .
    Ac-LEVD-CHO
  • HY-P1098B
    Ac2-26 ammonium
    5+ Cited Publications

    		 IKK Inflammation/Immunology
    Ac2-26 ammonium is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 ammonium induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ammonium ameliorates lung ischemia-reperfusion injury. Ac2-26 ammonium also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .
    Ac2-26 ammonium
  • HY-113963
    Ac-​IETD-​CHO

    		Apoptosis Cancer
    Ac- IETD- CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac- IETD- CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac- IETD- CHO also inhibits cytotoxic T lymphocytes induced cell death .
    Ac-​IETD-​CHO
  • HY-P1118
    Ac9-25

    		Formyl Peptide Receptor (FPR) Inflammation/Immunology
    Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .
    Ac9-25
  • HY-P2091
    Ac-YVAD-pNA

    		Caspase Inflammation/Immunology
    Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes .
    Ac-YVAD-pNA
  • HY-P10201
    Ac-GpYLPQTV-NH2

    		STAT Cancer
    Ac-GpYLPQTV-NH2 is a STAT3 inhibitor with an IC50 value of 0.33 μM. Ac-GpYLPQTV-NH2 has antitumor activity .
    Ac-GpYLPQTV-NH2
  • HY-P10144
    Ac-Orn-Phe-Arg-AMC

    		Biochemical Assay Reagents Others
    Ac-Orn-Phe-Arg-AMC is a potent fluorescent substrate of cd-Tryptase and β 1-Tryptase. Ac-Orn-Phe-Arg-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection .
    Ac-Orn-Phe-Arg-AMC
  • HY-P5983
    Ac-VEID-AFC
    1 Publications Verification

    		 Caspase Cancer
    Ac-VEID-AFC is a caspase-6 fluorogenic substrate, and can be used in the caspase 6 activity assay .
    Ac-VEID-AFC
  • HY-P10939
    Ac-DMLD-CMK

    		Caspase Pyroptosis Inflammation/Immunology Cancer
    Ac-DmLD-CMK is a caspase 3 inhibitor and a GSDME inhibitor. Ac-DmLD-CMK binds directly to the catalytic domain of caspase-3, blocks caspase-3-mediated cleavage of GSDME, inhibits the activation of caspase 3 and Gsdme in the caspase 3-Gsdme signaling pathway, and reduces the levels of pyroptosis and apoptosis as well as the expression of LDH, IL-6, IL-1β and IL-18. Ac-DmLD-CMK alleviates renal function deterioration, renal tubular epithelial cell injury, inflammatory cytokine secretion, pulmonary structural damage, and chemotherapy-induced nephrotoxicity .
    Ac-DMLD-CMK
  • HY-P3115
    Ac-LEVD-AFC

    		Fluorescent Dye Biochemical Assay Reagents Others
    Ac-LEVD-AFC is capspase-4 fluorogenic substrate peptide that can be used for caspase-4 activity studies .
    Ac-LEVD-AFC
  • HY-124680
    AC-263093 free base

    AC-093

    		 Neuropeptide FF Receptor Inflammation/Immunology
    AC-263093 free base (AC-093) functionally activates NPFFR2 and blocks activation of NPFFR1 with pKis of 6.9 and 7.0, respectively. AC-263093 free base has the potential for reversing opiate tolerance research .
    .
    AC-263093 free base
  • HY-P4449A
    Ac-VRPR-AMC TFA

    		Caspase Cancer
    Ac-VRPR-AMC TFA is a fluorogenic metacaspase substrate. Ac-VRPR-AMC TFA can be used to assay metacaspase activity .
    Ac-VRPR-AMC TFA
  • HY-P4417A
    Ac-IEPD-AMC TFA

    		Fluorescent Dye Others
    Ac-IEPD-AMC TFA is a fluorescent substrate used to measure protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC fluoresces under UV light irradiation and can emit fluorescent signals .
    Ac-IEPD-AMC TFA
  • HY-P10145
    Ac-LEVD-pNA

    		Biochemical Assay Reagents Caspase Others
    Ac-LEVD-pNA is a chromogenic substrate for caspase-4 and can be used to detect caspase-4 activity .
    Ac-LEVD-pNA
  • HY-P4532
    Ac-Leu-Val-Lys-Aldehyde

    		Cathepsin Neurological Disease
    Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II .
    Ac-Leu-Val-Lys-Aldehyde
  • HY-P5280
    Ac-KQL-AMC

    		Ser/Thr Protease Others
    Ac-KQL-AMC is a fluorogenic substrate that can be used to quantify Trypsin-like activity, resulting in detectable fluorescence when cleaved by the proteasome .
    Ac-KQL-AMC
  • HY-P5378A
    Ac-KQKLR-AMC TFA

    Cathepsin S substrate TFA

    		 Ser/Thr Protease Others
    Ac-KQKLR-AMC TFA is a substrate peptide of Cathepsin S fluorescently labeled with AMC (Ex/Em=354 nm/442 nm). Ac-KQKLR-AMC TFA can be used to measure Cathepsin S activity) .
    Ac-KQKLR-AMC TFA
  • HY-P11213
    Ac-RYQK(Ac)-AMC

    		Fluorescent Dye Metabolic Disease Cancer
    Ac-RYQK(Ac)-AMC (Compound S5) is a fluorescent substrate for SITR6, that is based on the H3 sequence. Ac-RYQK(Ac)-AMC mimics H3K56 deacetylation site and significantly increases the deacetylation signal with superior signal-to-background ratio. Ac-RYQK(Ac)-AMC can be used for ageing and cancers research .
    Ac-RYQK(Ac)-AMC
  • HY-P3364
    Ac-QPKK(Ac)-AMC

    		Fluorescent Dye Sirtuin HDAC Others
    Ac-QPKK(Ac)-AMC is a p53-derived peptide conjugated with a fluorophore, which serves as a fluorescent peptide substrate for detecting the deacylase activity of zinc-dependent HDACs and sirtuins (Ex = 360 nm; Em = 460 nm) .
    Ac-QPKK(Ac)-AMC
  • HY-P11326
    Ac-FR-AFC TFA

    		Cathepsin Fluorescent Dye Neurological Disease Cancer
    Ac-FR-AFC TFA is a fluorometric substrate for cathepsin L. Ac-FR-AFC TFA can be used for the research of glioblastoma .
    Ac-FR-AFC TFA
  • HY-P5378
    Ac-KQKLR-AMC

    Cathepsin S substrate

    		 Ser/Thr Protease Others
    Ac-KQKLR-AMC is a substrate peptide of Cathepsin S fluorescently labeled with AMC (Ex/Em=354 nm/442 nm). Ac-KQKLR-AMC can be used to measure Cathepsin S activity) .
    Ac-KQKLR-AMC
  • HY-P10236
    Ac-WEHD-pNA

    		Caspase Others
    Ac-WEHD-pNA is a colorimetric substrate for caspase 1, 4, 5 and 14, which is utilized to measure the caspase activity .
    Ac-WEHD-pNA
  • HY-118806A
    AC-42 hydrochloride

    		mAChR Neurological Disease
    AC-42 hydrochloride is the hydrochloride salt form of AC-42 (HY-118806). AC-42 hydrochloride is an allosteric agonist for muscarinic M1 receptor with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. AC-42 hydrochloride stimulates the inositol phosphate (IP)-accumulation and calcium mobilization in CHO cells .
    AC-42 hydrochloride
  • HY-P11491
    Ac2-26 (mouse)

    		Formyl Peptide Receptor (FPR) Reactive Oxygen Species (ROS) Inflammation/Immunology
    Ac2-26 (mouse) is the N-terminal active peptide of Annexin A1 (AnxA1). Ac2-26 (mouse) regulates the inflammatory response by modulating the formyl peptide receptor (FPR) signaling pathway. Ac2-26 (mouse) can promote the release of chemokines and inhibit the production of ROS. Ac2-26 (mouse) can be used for the research of inflammation, such as rheumatoid arthritis .
    Ac2-26 (mouse)
  • HY-P4449
    Ac-VRPR-AMC

    		Caspase Cancer
    Ac-VRPR-AMC is a fluorogenic metacaspase substrate. Ac-VRPR-AMC can be used to tests metacaspase activity .
    Ac-VRPR-AMC
  • HY-P11392
    Ac-IEAR-pNA

    		Cholinesterase (ChE) Biochemical Assay Reagents Others
    Ac-IEAR-pNA is the chromogenic substrate for quantifying endotoxin levels. Ac-IEAR-pNA is cleaved by HuBChE to produce p-nitroaniline product .
    Ac-IEAR-pNA
  • HY-P10241
    Ac-LEHD-CHO

    		Apoptosis Caspase Cancer
    Ac-LEHD-CHO is an inhibitor for caspase 8/9. Ac-LEHD-CHO prevents GalN/TNF-α-induced hepatotoxicity and hepatocyte apoptosis .
    Ac-LEHD-CHO
  • HY-P2285
    AC 253

    		Amyloid-β Neurological Disease
    AC 253, an amylin antagonist, inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM .
    AC 253
  • HY-P11297
    AC-SDKP-NH2

    		Angiotensin-converting Enzyme (ACE) Cardiovascular Disease
    AC-SDKP-NH2 is a substrate peptide of Angiotensin converting enzyme (ACE). AC-SDKP-NH2 has anti-inflammatory and anti-fibrotic activities. AC-SDKP-NH2 directly acts on tissues and prevents or reverses them from excessive fibrosis, but fails to reduce blood pressure and left ventricular hypertrophy (LVH). AC-SDKP-NH2 attenuates inflammation and cell differentiation, proliferation and migration, therefore reducing fibrosis in the heart, vessels and kidneys in mice model. AC-SDKP-NH2 can be used for cardiovascular diseases such as hypertension research .
    AC-SDKP-NH2
  • HY-P4443
    Ac-GAK-AMC

    		Fluorescent Dye Others
    Ac-GAK-AMC is a fluorescent substrate that can be used to measure protease activity. AMC (7-amino-4-methylcoumarin) is a fluorescent group. In the presence of protease, the protease will hydrolyze Ac-GAK-AMC into a fluorescent product .
    Ac-GAK-AMC
  • HY-P11325
    Ac-RR-AFC TFA

    		Cathepsin Fluorescent Dye Others
    Ac-RR-AFC TFA is a Cathepsin B fluorogenic substrate (Ex=400 nm, Em=505 nm). Cathepsin B activity in cells lysates is determined by measuring cleavage of Ac-RR-AFC TFA and its cleavage occurs at the RR-AFC amide bond. Ac-RR-AFC TFA can be used for activity assays and mechanistic studies on cathepsin B .
    Ac-RR-AFC TFA
  • HY-P10144A
    Ac-Orn-Phe-Arg-AMC acetate

    		Biochemical Assay Reagents Others
    Ac-Orn-Phe-Arg-AMC acetate is a potent fluorescent substrate of cd-Tryptase and β 1-Tryptase. Ac-Orn-Phe-Arg-AMC acetate releases amino-4-methylcoumarin (AMC) for fluorescence detection .
    Ac-Orn-Phe-Arg-AMC acetate
  • HY-P10231
    Ac-Phe-Thiaphe-OH

    		Carboxypeptidase Others
    Ac-Phe-Thiaphe-OH is a modified peptide, which is utilized as substrate for carboxypeptidase A (CPA) .
    Ac-Phe-Thiaphe-OH
  • HY-P11406
    Ac-RSLK-AMC

    		Fluorescent Dye Others
    Ac-RSLK-AMC is a fluorogenic substrate, can be used to measure the enzymatic activities of site-1 protease (S1P) .
    Ac-RSLK-AMC
  • HY-16021
    AC-430

    		JAK Inflammation/Immunology
    AC-430 is a JAK2 inhibitor. AC-430 can be used in the research of rheumatoid arthritis .
    AC-430
  • HY-157235
    AC Antibody affinity resin

    		Biochemical Assay Reagents Inflammation/Immunology
    AC Antibody affinity resin is AC commonly used packing. AC Antibody affinity resin has highly cross-linked agarose matrix with 85 μm of average particle size. AC Antibody affinity resin has alkali-resistant protein A derivative (E. coli) ligand. AC Antibody affinity resin can be used for antibody affinity chromatography .
    AC Antibody affinity resin

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