1 Result for "

ANCM-RMI interaction

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "ANCM-RMI interaction" in MCE Product Catalog:

Cat. No.: HY-P11224
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

RMI-L4 is an efficient cyclic peptide inhibitor that can specifically disrupt the interaction between FANCM and RMI proteins with an IC50 of 54 nM. RMI-L4 engages the FANCM-binding pocket of RMI1/2 with nanomolar affinity (KD = 2.5 nM). RMI-L4 cannot penetrate the cell membrane and can be used to study the FANCM-RMI pathway targeting cancer with alternate lengthening of telomeres (ALT) .
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