146 Results for "

Hepatoprotective activity

" in MedChemExpress (MCE) Product Catalog:
Products (146)

146 Results for "Hepatoprotective activity" in MCE Product Catalog:

38
Chlorogenic acid
Chlorogenic acid
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38 Publications Verification
Cat. No.: HY-N0055
CAS No.: 327-97-9
Synonyms: 3-O-Caffeoylquinic acid; Heriguard; NSC-407296
Category:  

Caprifoliaceae Anti-aging Lonicera japonica Thunb. Plants Endogenous metabolite Infection Human Gut Microbiota Metabolites Microorganisms Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Disease Research Fields Inflammation/Immunology Cancer

Target:  

HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Bacterial Influenza Virus Endogenous Metabolite

Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound .
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35
Rutin
Rutin
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35 Cited Publications
Cat. No.: HY-N0148
CAS No.: 153-18-4
Synonyms: Rutoside; Quercetin 3-O-rutinoside
Category:  

Flavonols Plants other families Flavonoids Leguminosae Sunscreen Phenols Polyphenols Cosmetic Research Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer

Target:  

Amyloid-β Autophagy Apoptosis Endogenous Metabolite

Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .
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35
Rutin hydrate
Rutin hydrate
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35 Cited Publications
Cat. No.: HY-N0148A
CAS No.: 207671-50-9
Synonyms: Rutoside hydrate; Quercetin 3-O-rutinoside hydrate
Category:  

Flavonols other families Flavonoids Phenols Polyphenols Plants

Target:  

Amyloid-β Autophagy Apoptosis Endogenous Metabolite

Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. Rutin hydrate attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .
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15
Thymoquinone
Thymoquinone
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15 Cited Publications
Cat. No.: HY-D0803
CAS No.: 490-91-5
Category:  

Quinones Nigella sativa L. Ranunculaceae Benzene Quinones Plants Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis VEGFR PI3K Akt

Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation .
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13
Cucurbitacin B
Cucurbitacin B
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13 Cited Publications
Cat. No.: HY-N0416
CAS No.: 6199-67-3
Category:  

Triterpenes Terpenoids Cucurbitaceae Trichosanthes cucumerina L. Plants Endogenous metabolite Disease Research Fields Cancer

Target:  

HIF/HIF Prolyl-Hydroxylase Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX

Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .
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11
Aucubin
Aucubin
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11 Cited Publications
Cat. No.: HY-N0664
CAS No.: 479-98-1
Category:  

Infection Eucommia ulmoides Oliver Neurological Disease Iridoids Terpenoids Eucommiaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

Bacterial

Aucubin is an iridoid glycoside component that acn be found in E. ulmoides. Aucubin can cross the blood-brain barrier (BBB) and has anti-anxiety, antidepressive and anti-neuroinflammatory effects. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .
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11
Ligustrazine
Ligustrazine
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11 Cited Publications
Cat. No.: HY-N0264
CAS No.: 1124-11-4
Synonyms: Chuanxiongzine; Tetramethylpyrazine
Category:  

Cardiovascular Disease Natural Products Neurological Disease Metabolic Disease Dicerothamnus rhinocerotis Plants Umbelliferae Disease Research Fields Inflammation/Immunology

Target:  

Reactive Oxygen Species (ROS) Akt NO Synthase Aminotransferases (Transaminases)

Ligustrazine (Chuanxiongzine) is an orally active, blood-brain barrier-permeable alkaloid. It can be isolated from Ligusticum striatum DC. Ligustrazine reduces ROS, upregulates the levels of p-Akt/Akt and p-eNOS/eNOS, and decreases ALT and AST. It inhibits glutamate excitotoxicity, calcium overload, oxidative stress, ischemia-reperfusion injury and atherosclerotic plaque progression, enhances synaptic plasticity, and improves neurological function, cerebral infarct volume and brain water content. Ligustrazine possesses anti-inflammatory, antioxidant, lipid-lowering, endothelial protective and hepatoprotective activities. It can be used in studies related to ischemic stroke, cerebral ischemia-reperfusion injury and atherosclerosis .
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11
Ligustrazine hydrochloride
Ligustrazine hydrochloride
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11 Cited Publications
Cat. No.: HY-N0935
CAS No.: 76494-51-4
Synonyms: Chuanxiongzine hydrochloride; Tetramethylpyrazine hydrochloride
Category:  

Alkaloids Other Alkaloids Other Diseases Dicerothamnus rhinocerotis Plants Umbelliferae Disease Research Fields

Target:  

Reactive Oxygen Species (ROS) Akt NO Synthase Aminotransferases (Transaminases)

Ligustrazine hydrochloride (Chuanxiongzine hydrochloride) is an orally active, blood-brain barrier-permeable alkaloid. It can be isolated from Ligusticum striatum DC. Ligustrazine hydrochloride reduces ROS, upregulates the levels of p-Akt/Akt and p-eNOS/eNOS, and decreases ALT and AST. It inhibits glutamate excitotoxicity, calcium overload, oxidative stress, ischemia-reperfusion injury and atherosclerotic plaque progression, enhances synaptic plasticity, and improves neurological function, cerebral infarct volume and brain water content. Ligustrazine hydrochloride possesses anti-inflammatory, antioxidant, lipid-lowering, endothelial protective and hepatoprotective activities. It can be used in studies related to ischemic stroke, cerebral ischemia-reperfusion injury and atherosclerosis .
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10
Silybin
Silybin
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10 Cited Publications
Cat. No.: HY-N0779A
CAS No.: 802918-57-6
Synonyms: Silibinin
Category:  

Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Flavanonols Glycine soya Flavonoids Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis

Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity .
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10
3,4-Dicaffeoylquinic acid
3,4-Dicaffeoylquinic acid
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10 Cited Publications
Cat. No.: HY-N0057
CAS No.: 14534-61-3
Synonyms: 3,4-Di-O-caffeoylquinic acid; Isochlorogenic acid B
Category:  

Infection Caprifoliaceae Ketones, Aldehydes, Acids Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields

Target:  

Free Radical Scavengers Glycosidase Influenza Virus Apoptosis Endogenous Metabolite

3,4-Dicaffeoylquinic acid (3,4-Di-O-caffeoylquinic acid), naturally isolated from Laggera alata, has antioxidative, DNA protective, neuroprotective and hepatoprotective properties. 3,4-Dicaffeoylquinic acid exerts apoptosis-mediated cytotoxicity and α-glucosidase inhibitory effects. 3,4-Dicaffeoylquinic acid possesses a unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL .
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10
Avicularin
Avicularin
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10 Cited Publications
Cat. No.: HY-N0222
CAS No.: 572-30-5
Category:  

Flavonols Flavonoids Phenols Polyphenols Plants Lauraceae Disease Research Fields Inflammation/Immunology Lindera aggregata (Sims) Kosterm.

Target:  

COX NF-κB PPAR ERK GLUT Apoptosis

Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities .
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8
Corilagin
Corilagin
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8 Cited Publications
Cat. No.: HY-N0462
CAS No.: 23094-69-1
Synonyms: NP-004255
Category:  

Infection Phyllanthus urinaria Linn. Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

Toll-like Receptor (TLR) Reverse Transcriptase Bacterial Apoptosis Autophagy

Corilagin, a gallotannin, has anti-tumor, anti-inflammatory and hepatoprotective activities. Corilagin inhibits activity of reverse transcriptase of RNA tumor viruses. Corilagin also inhibits the growth of Staphylococcus aureus with a MIC of 25 μg/mL. Corilagin shows anti-tumor activity on hepatocellular carcinoma and ovarian cancer model. Corilagin shows low toxicity to normal cells and tissues .
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7
Bergenin
Bergenin
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7 Cited Publications
Cat. No.: HY-N0017
CAS No.: 477-90-7
Synonyms: Cuscutin
Category:  

Infection Bergenia purpurascens (Hook. f. et Thoms.) Engl. Phenols Polyphenols Plants Saxifragaceae Disease Research Fields Inflammation/Immunology

Target:  

NF-κB Autophagy Apoptosis Bacterial Fungal Virus Protease

Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties .
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7
Farrerol
Farrerol
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7 Cited Publications
Cat. No.: HY-N0344
CAS No.: 24211-30-1
Synonyms: (-)-Farrerol
Category:  

Neurological Disease  Rhododendron dauricum Linn. Plants Flavonoids Flavonones Phenols Polyphenols Ericaceae Disease Research Fields Inflammation/Immunology

Target:  

Others

Farrerol is a bioactive constituent of Rhododendron, with broad activities such as anti-oxidative, anti-inflammatory, anti-tumor, neuroprotective and hepatoprotective effects .
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6
Lithospermic acid
Lithospermic acid
0 Images
6 Cited Publications
Cat. No.: HY-N0823
CAS No.: 28831-65-4
Synonyms: (+)-Lithospermic acid
Category:  

Labiatae Samanea saman (Jacq.) Merr. Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology

Target:  

NO Synthase AMPK Keap1-Nrf2 Xanthine Oxidase Apoptosis

Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo .
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5
Linalool,98% (stabilized with MEHQ)
Linalool,98% (stabilized with MEHQ)
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5 Cited Publications
Cat. No.: HY-N0368
CAS No.: 78-70-6
Category:  

Cardiovascular Disease Other Monoterpenes Terpenoids Amberboa moschata (L.) DC. Plants Umbelliferae Endogenous metabolite Disease Research Fields

Target:  

Apoptosis iGluR Endogenous Metabolite Bacterial TNF Receptor

Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .
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5
Curcumenol
Curcumenol
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5 Cited Publications
Cat. No.: HY-N2259
CAS No.: 19431-84-6
Synonyms: (+)-Curcumenol
Category:  

Neurological Disease Terpenoids Sesquiterpenes Plants Curcuma phaeocaulis Valeton Disease Research Fields Inflammation/Immunology Cancer Zingiberaceae

Target:  

Cytochrome P450 NF-κB MMP Interleukin Related TNF Receptor Akt p38 MAPK Ferroptosis Apoptosis CXCR COX Caspase Bcl-2 Family TGF-β Receptor

Curcumenol ((+)-Curcumenol) is a natural compound with oral efficacy, exhibiting an IC50 of 12.6 μM and a Ki of 10.8 μM against human CYP3A4. Curcumenol inhibits TNFα-induced phosphorylation/degradation of IκBα, phosphorylation/nuclear translocation of NF-κB p65, as well as the upregulation of MMP3, MMP9, MMP13, TRAF3, IL1RL1, TNFα and IL-1β. Curcumenol suppresses LPS-induced phosphorylation of Akt and p38 MAPK, as well as the production of pro-inflammatory mediators/proteins, and downregulates the SLC7A11/NF-κB/TGF-β pathway. Curcumenol binds to and inhibits the activation of Fyn and Lyn, blocks the function of downstream FcεRI signaling components, and reduces the release of allergic mediators/cytokines. Curcumenol upregulates the expression of KDM6B, and promotes chondrocyte proliferation and cartilage repair. Curcumenol induces ferroptosis and apoptosis, regulates the EMT process, and inhibits tumor growth and metastasis of triple-negative breast cancer. Curcumenol possesses anti-inflammatory, neuroprotective, antioxidant, antitumor, antiviral and hepatoprotective activities. Curcumenol can be used in research related to intervertebral disc degeneration, cancer, inflammation, central nervous system neurodegenerative diseases, allergic reactions and knee osteoarthritis .
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4
Schisandrin
Schisandrin
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4 Cited Publications
Cat. No.: HY-N0691
CAS No.: 7432-28-2
Synonyms: Schizandrin; Schizandrol; Schizandrol-A
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Autophagy

Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .
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4
Tubuloside A
Tubuloside A
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4 Cited Publications
Cat. No.: HY-N2155
CAS No.: 112516-05-9
Category:  

Simple Phenylpropanols Cistanche deserticola Ma Metabolic Disease Orobanchaceae Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields

Target:  

Others

Tubuloside A is a phenylethanoid glycoside with antioxidative effect and hepatoprotective activity.
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4
Alisol B 23-acetate
Alisol B 23-acetate
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4 Cited Publications
Cat. No.: HY-N0805
CAS No.: 26575-95-1
Synonyms: 23-Acetylalismol B; 23-O-Acetylalisol B; Alisol B monoacetate
Category:  

Triterpenes Alisma plantago-aquatica Linn. Terpenoids Other Diseases Plants Alismataceae Disease Research Fields

Target:  

Apoptosis Reactive Oxygen Species (ROS) CDK MMP PARP FXR Syk

Alisol B 23-acetate is an orally active prototerpane-type triterpenoid. Alisol B 23-acetate can be isolated from Alisma orientalis. Alisol B 23-acetate induces Apoptosis, promotes ROS generation, downregulates CDK4/6, MMP-2/9, upregulates cleaved PARP, activates FXR and inhibits Syk. Alisol B 23-acetate has anti-inflammatory and hepatoprotective activities. Alisol B 23-acetate protects the kidney from ischemia-reperfusion injury. Alisol B 23-acetate has anticancer activity against ovarian cancer, colon cancer, lung cancer, and gastric cancer. Alisol B 23-acetate can be used in the study of atherosclerosis and allergic asthma .
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