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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
221 Results for "
LOX
" in MedChemExpress (MCE) Product Catalog:
Products (221)
221 Results for "LOX" in MCE Product Catalog:
258
258 Publications Verification
Synonyms: Angiotensin II; Ang II; DRVYIHPF
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258
258 Publications Verification
Synonyms: Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate
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Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
258
258 Publications Verification
Synonyms: Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA
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26
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Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Extract Disease Research Fields Inflammation/Immunology
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19
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8
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Neurological Disease Anti-aging Lignans Plants Other Families Extract Phenols Polyphenols Phenylpropanoids Disease Research Fields Cancer
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8
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Onvoloxastat (ML355) is an orally active selective 12-LOX inhibitor with an IC50 of 0.34 μM. Onvoloxastat inhibits platelet activation by blocking thrombin- or thromboxane A2-induced phosphorylation of Akt, PI3K and Erk1/2. At low doses (1-20 μM), it mainly acts by reducing ROS levels, while at high doses (50 μM), it functions via activating the cAMP pathway. Onvoloxastat can be used in research related to thrombosis and diabetes .
7
7 Cited Publications
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JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and an active metabolite of GPX4 inhibitor ML-210. JKE-1674, an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. JKE-1674 can convert into a nitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML-210 and is completely rescued by ferroptosis inhibitors .
5
5 Cited Publications
Cat. No.: HY-N0232
CAS No.: 18642-23-4
5
5 Cited Publications
Cat. No.: HY-N1996
CAS No.: 23094-71-5
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Combretaceae Extract Phenols Polyphenols Terminalia chebula Retz. Plants Disease Research Fields Inflammation/Immunology
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4
4 Cited Publications
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ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2 . ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D .
4
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Rutaceae Extract Flavonoids Neurological Disease Flavones Plants Disease Research Fields Citrus Cancer
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3
3 Cited Publications
Synonyms: LOX-IN-3 dihydrochloride
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PXS-5505 anhydrous (LOX-IN-3 dihydrochloride) is an orally active lysyl oxidase (LOX) inhibitor. PXS-5505 anhydrous can be used for fibrosis, cancer and angiogenesis research .
3
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PXS-5505 free base (LOX-IN-3) is an orally active lysyl oxidase (LOX) inhibitor. PXS-5505 free base can be used for fibrosis, cancer and angiogenesis research .
3
3 Cited Publications
Cat. No.: HY-138625B
CAS No.: 2414974-55-1
Synonyms: LOX-IN-3 dihydrochloride monohydrate
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PXS-5505 (LOX-IN-3 dihydrochloride monohydrate) (Compound 33) is an orally active lysyl oxidase (LOX) inhibitor. PXS-5505 can be used for fibrosis, cancer and angiogenesis research .
3
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BI-0115 is a selective inhibitor of LOX-1 (IC50=5.4 μM) that blocks cellular uptake of oxLDL. BI-0115 binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain .
3
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Flavonoids Glycine max (L.) merr Flavones Other Diseases Phenols Polyphenols Leguminosae Extract Plants Disease Research Fields
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2
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2
2 Cited Publications
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12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway .12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
