585 Results for "

NSCs

" in MedChemExpress (MCE) Product Catalog:
Products (585)

585 Results for "NSCs" in MCE Product Catalog:

202
202 Publications Verification
Referencia número: HY-17364
No. CAS: 85622-93-1
Synonyms: NSC 362856; CCRG 81045; TMZ
Áreas de investigación:  

Cancer

Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .
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177
177 Cited Publications
Referencia número: HY-A0004
No. CAS: 2353-33-5
Synonyms: 5-Aza-2'-deoxycytidine; 5-AZA-CdR; NSC 127716
Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell Apoptosis. Decitabine has potent anticancer activity .
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111
111 Cited Publications
Referencia número: HY-B0069
No. CAS: 21679-14-1
Synonyms: F-ara-A; NSC 118218
Áreas de investigación:  

Cancer

Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes .
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95
95 Cited Publications
Referencia número: HY-17393
No. CAS: 41575-94-4
Synonyms: NSC 241240
Áreas de investigación:  

Cancer

Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.
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84
84 Cited Publications
Referencia número: HY-14655
No. CAS: 599-79-1
Pureza:  98.75%
Synonyms: NSC 667219; Salicylazosulfapyridine
Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .
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77
77 Cited Publications
Referencia número: HY-N0488A
No. CAS: 57-22-7
Synonyms: Leurocristine; NSC-67574; 22-Oxovincaleukoblastine
Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .
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77
77 Cited Publications
Referencia número: HY-N0488
No. CAS: 2068-78-2
Synonyms: Leurocristine sulfate; NSC-67574 sulfate; 22-Oxovincaleukoblastine sulfate
Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) sulfate is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .
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67
67 Cited Publications
Referencia número: HY-15146
No. CAS: 501919-59-1
Pureza:  98.35%
Synonyms: S3I-201
Target:  

STAT

Áreas de investigación:  

Cancer

NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 μM .
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56
56 Cited Publications
Referencia número: HY-15723A
No. CAS: 1177865-17-6
Pureza:  99.41%
Target:  

Ras Apoptosis

Áreas de investigación:  

Cancer

NSC 23766 trihydrochloride is an inhibitor of Rac1 activation.
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56
56 Cited Publications
Referencia número: HY-15723
No. CAS: 733767-34-5
Pureza:  99.86%
Target:  

Ras

Áreas de investigación:  

Cancer

NSC 23766 is a cell-permeable, reversible and specific inhibitor of Rac GTPase, used for cancer treatment.
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45
45 Cited Publications
Referencia número: HY-19543
No. CAS: 14907-98-3
Synonyms: NSC 172924
Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent . Brusatol increases cellular apoptosis .
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39
39 Cited Publications
Referencia número: HY-13768
No. CAS: 123948-87-8
Synonyms: SKF 104864A; NSC 609669
Áreas de investigación:  

Cancer

Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity .
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37
37 Cited Publications
Referencia número: HY-15695
No. CAS: 58-60-6
Pureza:  99.86%
Synonyms: NSC 3056
Puromycin aminonucleoside (NSC 3056) is the aminonucleoside portion of the antibiotic puromycin, and used in nephrosis animal models . Puromycin aminonucleoside induces apoptosis . Puromycin aminonucleoside is a reversible inhibitor of dipeptidyl peptidase II and cytosol alanyl aminopeptidase . Puromycin aminonucleoside induces secretion of cell migrasome .
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29
29 Cited Publications
Referencia número: HY-N0142
No. CAS: 60-82-2
Synonyms: NSC 407292; RJC 02792
Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill.,has anti-inflammatory activities. Phloridzin is a specific,competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM,respectively .Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation .
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27
27 Cited Publications
Referencia número: HY-N0004
No. CAS: 28957-04-2
Synonyms: NSC-250682; Isodonol
Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.
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24
24 Cited Publications
Referencia número: HY-15036
No. CAS: 15307-86-5
Pureza:  99.92%
Target:  

COX Apoptosis

Áreas de investigación:  

Inflammation/Immunology Cancer

Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
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24
24 Cited Publications
Referencia número: HY-15038
No. CAS: 15307-81-0
Pureza:  99.99%
Target:  

COX Apoptosis

Áreas de investigación:  

Inflammation/Immunology Cancer

Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
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24
24 Cited Publications
Referencia número: HY-15037
No. CAS: 15307-79-6
Pureza:  99.94%
Synonyms: GP 45840
Target:  

COX Apoptosis

Áreas de investigación:  

Inflammation/Immunology Cancer

Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
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24
24 Cited Publications
Referencia número: HY-15036A
No. CAS: 78213-16-8
Pureza:  99.95%
Target:  

COX Apoptosis

Áreas de investigación:  

Inflammation/Immunology Cancer

Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
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23
23 Cited Publications
Referencia número: HY-101084
No. CAS: 113104-25-9
Pureza:  ≥98.0%
Áreas de investigación:  

Cancer

NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR . NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM .
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