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Results for "

NSCs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) ADC Linker (1) Adenosine Kinase (2) Adenosine Receptor (1) Adrenergic Receptor (1) Akt (9) Amino Acid Derivatives (2) Aminopeptidase (2) AMPK (4) Amyloid-β (1) Angiotensin Receptor (1) Antibiotic (18) Antifolate (2) Apoptosis (109) Arp2/3 Complex (2) Aryl Hydrocarbon Receptor (6) Atg4 (1) ATP Synthase (2) Autophagy (31) Bacterial (40) Bcl-2 Family (7) Bcr-Abl (4) BCRP (2) Beta-secretase (1) Biochemical Assay Reagents (17) c-Met/HGFR (1) c-Myc (6) Calcium Channel (8) Carbonic Anhydrase (5) Carboxypeptidase (1) Caspase (9) CCR (1) CDK (6) Checkpoint Kinase (Chk) (3) Chloride Channel (5) Cholinesterase (ChE) (1) Claudin (2) Collagen (1) COX (18) Cuproptosis (1) CXCR (1) Cytochrome P450 (4) Deubiquitinase (3) Dihydrofolate reductase (DHFR) (3) Dipeptidyl Peptidase (2) DNA Alkylator/Crosslinker (15) DNA Methyltransferase (5) DNA Stain (2) DNA/RNA Synthesis (51) Dopamine Receptor (1) Drug Derivative (17) Drug Intermediate (15) Drug Isomer (4) Drug Metabolite (7) E1/E2/E3 Enzyme (8) EBV (1) EGFR (8) Endogenous Metabolite (44) Environmental Pollutants (8) Epigenetic Reader Domain (4) ERK (5) Estrogen Receptor/ERR (1) Ferroptosis (7) FGFR (3) Flavivirus (1) Fluorescent Dye (5) FOXO (2) Fungal (17) G-quadruplex (1) GABA Receptor (6) Gli (1) GLUT (2) Glutamate Dehydrogenase (GLDH) (1) Glutathione Peroxidase (1) GSK-3 (1) HCV (2) HDAC (1) Histamine Receptor (5) Histone Acetyltransferase (5) Histone Demethylase (3) Histone Methyltransferase (4) HIV (15) HPV (2) HSP (4) HSV (3) iGluR (7) IKK (1) Indoleamine 2,3-Dioxygenase (IDO) (2) Influenza Virus (3) Insecticide (1) Integrin (4) Interleukin Related (4) IRE1 (2) Isotope-Labeled Compounds (72) JAK (3) JNK (7) Keap1-Nrf2 (1) Kinesin (2) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (2) Liposome (1) LPL Receptor (1) mAChR (1) MDM-2/p53 (13) mGluR (1) Microtubule/Tubulin (11) Mitophagy (1) Mitosis (6) MMP (3) MOFs (7) Monoamine Oxidase (1) mTOR (7) nAChR (2) Necroptosis (1) NF-κB (11) NO Synthase (1) NOD-like Receptor (NLR) (1) Notch (2) Nucleoside Antimetabolite/Analog (17) Opioid Receptor (1) Orthopoxvirus (4) P-glycoprotein (5) P2Y Receptor (2) p38 MAPK (7) p97 (2) PANoptosis (1) Parasite (12) PARP (4) PD-1/PD-L1 (1) PERK (1) PGC-1α (5) Phosphatase (9) Phosphodiesterase (PDE) (1) Phospholipase (5) PI3K (4) Pim (1) PKC (6) Potassium Channel (6) PROTACs (2) Proteasome (1) Quinone Reductase (2) RANKL/RANK (1) Ras (11) Reactive Oxygen Species (ROS) (8) Reference Standards (72) RET (1) Reverse Transcriptase (4) RIO Kinase (1) ROCK (1) RUNX (1) SARS-CoV (5) Ser/Thr Protease (2) SGLT (2) SHP1 (2) SHP2 (3) Sigma Receptor (1) Sirtuin (1) Sodium Channel (1) SOS1 (3) Src (1) STAT (7) Stearoyl-CoA Desaturase (SCD) (1) Steroid Sulfatase (1) STING (1) Syk (1) TET Protein (3) TGF-β Receptor (1) TNF Receptor (3) Topoisomerase (22) Transmembrane Glycoprotein (1) UGT (1) VDAC (2) VEGFR (2) Virus Protease (1) Wnt (4) YAP (1) β-catenin (3)
By Research Areas:	Cancer (334) Cardiovascular Disease (26) Endocrinology (8) Infection (75) Inflammation/Immunology (73) Metabolic Disease (32) Neurological Disease (55)
Oligonucleotides:	Adenosine (1) Nucleoside Analogs (2) Cytidine (1)

560

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15036

Diclofenac 20+ Cited Publications	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15038

Diclofenac potassium 20+ Cited Publications	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15827

NSC 405020 3 Publications Verification	MMP	Cardiovascular Disease Cancer
NSC 405020 is a specific MMP14 inhibitor. NSC 405020 can directly interact with the hemopexin domain of MMP14. NSC 405020 reduces the expression of full length and active cleaved Notch3 (NICD3). NSC 405020 can be used to research vestibular schwannoma, hemostasis and thrombosis .

HY-18756

NSC-87877 3 Publications Verification	SHP2 SHP1 Phosphatase Apoptosis	Others
NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26) .

HY-120782

Yhhu-3792 2 Publications Verification	Notch	Neurological Disease
Yhhu-3792 is a Notch activator. Yhhu-3792 enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 promotes the expression of Hes3 and Hes5. Yhhu-3792 increases the spatial and episodic memory abilities of mice. Yhhu-3792 can be used for the study of neurodegenerative diseases (such as Alzheimer's disease) or for neural regeneration after brain injury .

HY-15037

Diclofenac Sodium 20+ Cited Publications GP 45840	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-16933

L-Alanosine 1 Publications Verification NSC-153353; SDX-102	Antibiotic DNA/RNA Synthesis	Infection Cancer
L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine is the inhibitor for methylthioadenosine phosphorylase (MTAP) .

HY-115492

NSC668394 3 Publications Verification	PKC	Cancer
NSC668394 is a potent ezrin (Thr567) phosphorylation inhibitor, with a K_d of 12.59 μM. NSC668394 inhibit ezrin T567 phosphorylation caused by PKCΙ primarily via their binding to ezrin. NSC668394 can be used to prevent tumor metastasis .

HY-15036A

Diclofenac diethylamine 20+ Cited Publications	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-19387

Didox 10+ Cited Publications NSC-324360	DNA/RNA Synthesis	Cancer
Didox (NSC-324360) is a synthetic ribonucleotide reductase (RR) inhibitor.

HY-122258

NSC-370284	STAT TET Protein	Cancer
NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5 .

HY-107194

NSC12	FGFR c-Myc DNA/RNA Synthesis Caspase Reactive Oxygen Species (ROS)	Cancer
NSC12 is an orally active pan-FGF trap. NSC12 inhibits the interaction between FGF2/FGFR. NSC12 suppresses the phosphorylation of FGFR3. NSC12 reduces c-Myc levels, induces DNA damage, triggers the cleavage of Caspase 3, and promotes ROS production. NSC12 exhibits anticancer activity against lung cancer and multiple myeloma .

HY-108638

NSC 146109 hydrochloride 2 Publications Verification XI-011 hydrochloride	MDM-2/p53 Apoptosis PARP	Cancer
NSC 146109 hydrochloride (XI-011 hydrochloride) is a p53 activator and MDMX inhibitor. NSC 146109 hydrochloride inhibits MDMX gene transcription, downregulates MDMX mRNA and protein levels, stabilizes p53 and activates the transcriptional activity of p53. NSC 146109 hydrochloride induces cancer cell apoptosis (apoptosis) and inhibits the growth of transformed cells. NSC 146109 hydrochloride inhibits the growth of xenograft tumors. NSC 146109 hydrochloride can be used in research related to breast cancer and cervical cancer .

HY-W016794

NSC3852	Reactive Oxygen Species (ROS) Apoptosis	Cancer
NSC3852 exhibits anti-proliferative activity against cancer cell MCF-7. NSC3852 promotes the ROS generation, DNA damage, and apoptosis in MCF-7. NSC3852 exhibits anti-tumor against leukemia in mouse model

HY-141687

NSC 107512 1 Publications Verification	CDK Apoptosis	Cancer
NSC 107512 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9). NSC 107512 is a class of sangivamycin-like molecules (SLM). NSC 107512 inhibits growth and induces apoptosis of multiple myeloma tumors .

HY-122066

NSC47924	Others	Infection
NSC47924 is a laminin receptor (LR) inhibitor. NSC47924 affects 37/67 kDa LR cell surface localization and interaction with the cellular prion protein. NSC47924 can be used for testing prion diseases .

HY-18756A

NSC-87877 disodium 3 Publications Verification	SHP2 SHP1 Phosphatase Apoptosis	Cancer
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26) .

HY-15036R

Diclofenac (Standard)	Reference Standards COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (Standard) is the analytical standard of Diclofenac. This product is intended for research and analytical applications. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-145330

NSC639828 2 Publications Verification	DNA/RNA Synthesis	Cancer
NSC639828 is a potent inhibitor of DNA polymerase α with an IC₅₀ of 70 μM. NSC639828 has high antitumor activity. NSC639828 has the potential for researching cancer disease .

HY-160638

NSC-311068	TET Protein	Cancer
NSC-311068 is TET1 inhibitor. NSC-311068 selectively suppress TET1 transcription and 5-hydroxymethylcytosine (5hmC) modification. NSC-311068 represses the level of TET1 expression and the global 5hmC level. NSC-311068 effectively inhibits cell viability in AML cells with high expression of TET1 .

HY-Y0124S

NSC 16590-d6 α,α-Dimethylglycine-d₆; α-Aminoisobutanoic acid-d₆	Isotope-Labeled Compounds Endogenous Metabolite	Others
NSC 16590-d₆ is the deuterium labeled NSC 16590. NSC 16590 inhibits the production of endogenous ethylene in the cotyledonary segments of cocklebur.

HY-160793

NSC80734	Interleukin Related	Inflammation/Immunology
NSC80734 is a IL- 18 inhibitor. NSC80734 disrupts hIL-18 binding to the ectromelia virus IL-18BP. NSC80734 inhibits IL-18-induced production of IFN-γ .

HY-176902

NSC126188	ROCK Akt FOXO Apoptosis	Cancer
NSC126188 is a RhoB inducer. NSC126188 can induce apoptosis by inhibiting Akt/FoxO3 signaling. NSC126188 can be used for the research of cancer, such as prostate cancer .

HY-171152A

NSC 357754 dihydrochloride	Claudin	Metabolic Disease
NSC 357754 dihydrochloride is an inhibitor of Claudin. NSC 357754 dihydrochloride can increase the transepithelial electrical resistance of cells and reduce the permeability of specific cations. NSC 357754 dihydrochloride can be used in the research of intestinal diseases mediated by Claudin-2 and/or Claudin-15 .

HY-18594

NSC-41589	Drug Derivative	Others
NSC-41589 is N-[2-(methylsulfanyl) phenyl]acetamide.

HY-Y0219S1

1,2,4-Triazole-d3 s-Triazole-d₃; Pyrrodiazole-d₃	Isotope-Labeled Compounds	Others
NSC 83128-d₃ is the deuterium labeled NSC 83128 .

HY-19820

NSC45586	Akt Ser/Thr Protease	Neurological Disease Cancer
NSC45586 is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 can activate AKT in neurons .

HY-120782A

Yhhu-3792 hydrochloride	Notch	Neurological Disease
Yhhu-3792 hydrochloride is a Notch activator. Yhhu-3792 hydrochloride enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 hydrochloride promotes the expression of Hes3 and Hes5. Yhhu-3792 hydrochloride increases the spatial and episodic memory abilities of mice. Yhhu-3792 hydrochloride can be used for the study of neurodegenerative diseases (such as Alzheimer's disease) or for neural regeneration after brain injury .

HY-15038R

Diclofenac potassium (Standard)	Reference Standards COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (potassium) (Standard) is the analytical standard of Diclofenac (potassium). This product is intended for research and analytical applications. Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15036AR

Diclofenac diethylamine (Standard)	Reference Standards COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (diethylamine) (Standard) is the analytical standard of Diclofenac (diethylamine). This product is intended for research and analytical applications. Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-124486

NSC-88915	Phosphodiesterase (PDE)	Others
NSC-88915 is an inhibitor of Tdp1 with an IC₅₀ of 7.7 μM. NSC-88915 is a C21-subsitited progesterone derivative .

HY-N16121

12-Deoxyphorbol 13-isobutyrate	PKC	Neurological Disease
12-Deoxyphorbol 13-isobutyrate (ER272) (DPB), a diterpene, is a PKCα activator. 12-Deoxyphorbol 13-isobutyrate can be isolated from Euphorbia resinifera's latex. 12-Deoxyphorbol 13-isobutyrate facilitates neural stem cells (NSCs) proliferation and activation as well as TGFα release in a reaction dependent on PKCα activation. 12-Deoxyphorbol 13-isobutyrate increases cognitive performance and hippocampal neurogenesis in senescence-accelerated mouse-prone (SAMP8) models. 12-Deoxyphorbol 13-isobutyrate can be used for neurodegenerative diseases research .

HY-176433

NSC-323241	Flavivirus	Infection
NSC-323241 is a potent STT3A-mediated mega protein complex assembly inhibitor. NSC-323241 disrupts he endoplasmic reticulum (ER) mega complex nucleated by STT3A during dengue virus (DENV) and Zika virus (ZIKV) infection. NSC-323241 targets the binding of STT3A subcomplex with viral nonstructural proteins (e.g., NS2B, NS3) and host translocon proteins, disrupting the formation of viral replication microenvironment. NSC-323241 is promising for research of flavivirus infection, such as dengue fever and Zika virus .

HY-134309

NSC 288387	Virus Protease	Infection
NSC 288387 is a pan-flavivirus MTase inhibitor. NSC 288387 binds to the SAM-binding pocket. NSC 288387 inhibits ZIKV with an IC₅₀ of 0.2 μM. NSC 288387 also inhibits viral replication in cell culture .

HY-Y1675S

NSC 65593-d4 m-Acetylanisole-d₄; m-Methoxyacetophenone-d₄	Isotope-Labeled Compounds	Others
NSC 65593-d₄ is the deuterium labeled NSC 65593 .

HY-144445

NSC114126	EGFR	Cancer
NSC114126 is a potent and orally active inhibitor of EGFR tyrosine kinase (EGFR-TK). NSC114126 has strong antiproliferative activities. NSC114126 has the potential for the research of cancer diseases .

HY-168602

NSC-217913	E1/E2/E3 Enzyme	Cancer
NSC-217913 is an inhibitor of WWP1 with an IC₅₀ value of 158.3 μM .

HY-105293

NSC 727357	DNA/RNA Synthesis Topoisomerase	Cancer
NSC 727357 is a DNA intercalator and topoisomerase inhibitor with antitumor activity. NSC 727357 can inhibit cells proliferation and induce G1 phase arrest. NSC 727357 can be used for the research of cancer, such as melanoma .

HY-144105

NSC405640	MDM-2/p53	Cancer
NSC405640 is a potent inhibitor of the MDM2-p53 interaction. NSC405640 rescues structural p53 mutations. NSC405640 selectively inhibits the growth of cell lines with wild-type p53 .

HY-105489

UC-84 NSC-615985	Reverse Transcriptase HIV	Infection
UC-84 (NSC-615985) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with anti-HIV activity .

HY-B1714

NSC 601980 analog	Drug Derivative	Cancer
NSC 601980 analog is an analogue of NSC601980. In yeast screening experiments, NSC 601980 exhibited antitumor activity, effectively inhibiting cell proliferation in both COLO 205 and HT29 cell lines, with Log GI 50 values of -6.6 and -6.9, respectively.

HY-118365

NSC 140873	RUNX	Infection Cancer
NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335) .

HY-180498

NSC 57148	EGFR	Cancer
NSC 57148 is a selective Grb7 SH2 domain antagonist with an IC₅₀ value of 1.1 μM. NSC 57148 reduces cancer cell proliferation and migration. NSC 57148 is promising for research of Grb7-overexpressing malignancies such as breast and pancreatic cancers .

HY-153719

NSC111552	SARS-CoV	Infection
NSC111552 is a potent SARS-CoV-2 NSP14 MTase inhibitor. NSC111552 inhibits the FL-NAH binding to the SARS-CoV-2 NSP14 MTase with an IC₅₀ of 5.1 μM .

HY-101796

NSC-70220	Ras SOS1	Cancer
NSC-70220 is a selective and allosteric SOS1 inhibitor. NSC-70220 inhibits allosteric site activation, and partially inhibited catalytic site activation. NSC-70220 has an anticancer effect .

HY-119172R

NSC-60339 (Standard)	Bacterial	Infection Inflammation/Immunology Cancer
NSC-60339 (Standard) is the analytical standard of NSC-60339. This product is intended for research and analytical applications. NSC-60339, an efflux pump inhibitor and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeutic agent .

HY-117481

NSC-639829	Apoptosis	Cancer
NSC-639829 is a Benzoylphenylurea (BPU) analogue which has antitumor activity. NSC-639829 is promising for research of refractory metastatic cancer .

HY-164402

NSC-124854	DNA/RNA Synthesis	Cancer
NSC-124854 is a DNA polymerase β (Pol-β) inhibitor with an IC₅₀ of 5.3 μM. NSC-124854 has antitumor activity .

HY-117831

NSC-79887	Endogenous Metabolite Bacterial	Infection
NSC-79887 is a nucleoside hydrolase (NH) inhibitor with activity against Bacillus anthracis. NSC-79887 is considered a good candidate inhibitor of nucleoside hydrolases for biological testing and further development. The pharmacokinetic (ADMET) prediction of NSC-79887 showed that all physicochemical parameters were within the acceptable range for human use .

HY-19539

NSC-658497	SOS1 Ras	Cancer
NSC-658497 is an effective inhibitor of Ras-GEF, SOS1. NSC-658497 binds to SOS1, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity. NSC-658497 showed dose-dependent efficacy in inhibiting Ras, downstream signaling activities, and associated cell proliferation .

Cat. No.	Product Name

HY-L013

Neuronal Signaling Compound Library

3,802 compounds

Neuronal Signaling is involved in the regulation of the mechanisms of the central nervous system (CNS) such as its structure, function, genetics and physiology as well as how this can be applied to understand diseases of the nervous system. Every information processing system in the CNS is composed of neurons and glia, neurons have evolved unique capabilities for intracellular signaling (communication within the cell) and intercellular signaling (communication between cells). G protein-coupled receptors (GPCRs), including 5-HT receptor, histamine receptor, opioid receptor, etc. are the largest class of sensory proteins and are important therapeutic targets in Neuronal Signaling. Besides, Notch signaling, such as β- and γ-secretase, also plays multiple roles in the development of the CNS including regulating neural stem cell (NSC) proliferation, survival, self-renewal and differentiation. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Notch signaling in neurons, glia, and NSCs is also involved in pathological changes that occur in disorders such as stroke, Alzheimer's disease and CNS tumors. Thus, targeting Neuronal Signaling, such as notch signaling and GPCRs, can be used as therapeutic interventions for several different CNS disorders.

MCE designs a unique collection of 3,802 Neuronal Signaling-related compounds that act as a useful tool for the research of neuronal regulation and neuronal diseases.

Cat. No.	Product Name	Type

HY-123533

Resorufin NSC 12097	Fluorescent Dye
Resorufin (NSC 12097) is a highly fluorescent pink dye. Resorufin shows favorable properties such as water solubility, red-shifted absorption/emission signals. Resorufin is used for the detection of ROS/RNS and a second analyte .

HY-D0221

2,4,6-Tri-2-pyridinyl-1,3,5-triazine NSC 112125; 2,4,6-Tipyidyl-s-tiazie	Fluorescent Dye
2,4,6-Tri-2-pyridinyl-1,3,5-triazine (NSC 112125) is a colorimetric reagent for detecting iron. 2,4,6-Tri-2-pyridinyl-1,3,5-triazine forms a complex with Fe (II) and can be quantified as a measure of iron concentration by colorimetric detection at 594 nm .

HY-123533A

Resorufin sodium salt NSC 12097 sodium salt	Fluorescent Dye
Resorufin sodium salt (NSC 12097) is a highly fluorescent pink dye. Resorufin sodium salt shows favorable properties such as water solubility, red-shifted absorption/emission signals. Resorufin sodium salt is used for the detection of ROS/RNS and a second analyte .

HY-121986

Yellow AB Solvent yellow 5	Fluorescent Dye
Yellow AB (Solvent yellow 5) is an azo dye that can be used as food dye .

HY-15907

BBD NSC240867; Benzylamino-NBD	Fluorescent Dye
BBD (NSC240867) is a biochemical reagent/chromogenic reagent.

HY-W011422

2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone

NSC 528

Fluorescent Dye

2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone (NSC 528) is a colorimetric dye used for the detection of phenolic compounds. 2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone reacts with phenolic compounds at a pH of about 9.4 to produce an indigo dye. 2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone has been used as a Gibbs reagent for the colorimetric detection of phenolic compounds. 2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone has also been used in a colorimetric reaction for the quantitative colorimetric detection of aflatoxins, turning the colorless aflatoxins green with an absorption band at 673 nm.

Cat. No.	Product Name	Type

HY-Y1217

1-Cyclohexanol Hydroxycyclohexane; NSC 54711; Naxol; Cyclohexanol	Biochemical Assay Reagents
1-Cyclohexanol (Hydroxycyclohexane; NSC 5471) is an orally active Cramer Class I flavor ingredient that can be used in fragrances. 1-Cyclohexanol has a wide margin of safety and is environmentally friendly .

HY-Y1217R

1-Cyclohexanol (Standard) Hydroxycyclohexane (Standard); NSC 54711 (Standard); Naxol (Standard); Cyclohexanol (Standard)	Biochemical Assay Reagents
1-Cyclohexanol (Hydroxycyclohexane; NSC 54711) (Standard) is the analytical standard of 1-Cyclohexanol (HY-Y1217). This product is intended for research and analytical applications. 1-Cyclohexanol is an orally active Cramer Class I flavor ingredient that can be used in fragrances. 1-Cyclohexanol has a wide margin of safety and is environmentally friendly.

HY-W416322

4-Nitrophenyl2,6-di-O-benzoyl-a-D-galactopyranoside	Biochemical Assay Reagents
Diethanolamine (DEOA LF; NSC 4959) is a biochemical assay reagent.

HY-119606

Bacimethrin NSC 66577	Biochemical Assay Reagents
Bacimethrin (NSC 66577) is an antibacterial agent and is thiamin biosynthesis antagonist.Bacimethrin inhibits bacterial and yeast growth .

HY-W311715

4-Methylphenylglyoxal	Biochemical Assay Reagents
4-Methylphenylglyoxal (NSC 402744) is a kind of biological materials or organic compounds that are widely used in life science research.

Cat. No.	Product Name	Target	Research Area

HY-W039756

Boc-Ala-Ala-OH NSC 334362	Amino Acid Derivatives	Others
Boc-Ala-Ala-OH (NSC 334362) is an Alanine derivative. Boc-Ala-Ala-OH is used in the preparation of anti-bacterial agent .

HY-W141916

Pentaglycine Tetraglycylglycine; Gly-Gly-Gly-Gly-Gly; NSC 96353	Amino Acid Derivatives Bacterial	Infection
Pentaglycine (Tetraglycylglycine; NSC 96353) is a bridging structure composed of five glycine residues. Pentaglycine serves as a characteristic peptidoglycan cross-bridge component of staphylococci and a specific substrate for lysostaphin. Pentaglycine maintains the integrity of the peptidoglycan cell wall of Staphylococcus aureus via peptide chain cross-linking and regulates bacterial growth. Pentaglycine expression is downregulated in high-glucose environments, inhibiting bacterial proliferation. Pentaglycine can be applied to studies related to Staphylococcus aureus infection .

HY-W010955

Z-Phe-Leu-OH NSC 334018	Carboxypeptidase	Others
Z-Phe-Leu-OH (NSC 334018) is a dipeptide acid. Z-Phe-Leu-OH undergoes hydrolysis by carboxypeptidase Y to release L-leucine. Z-Phe-Leu-OH acts as a substrate to assay carboxypeptidase Y peptidase activity .

HY-P4644

Tryptophylleucine NSC 286600	Peptides	Others
Tryptophylleucine (NSC 286600) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4663

Val-Gly-Ser-Glu NSC 350591	Peptides	Cancer
Val-Gly-Ser-Glu (NSC 350591) is an ECF-A tetrapeptide. Val-Gly-Ser-Glu dose-dependently increases the number of human eosinophils, but not neutrophils, rosetting with complement-coated sheep erythrocytes (EAC3b) .

HY-P4631

Tryptophylalanine NSC 97949	Peptides	Others
Tryptophylalanine (NSC 97949) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P5024

Cbz-Ile-Pro-OH NSC 333754	Peptides	Others
Cbz-Ile-Pro-OH (NSC 333754) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4698

Tri-valine NSC 35938	Peptides	Metabolic Disease
Tri-valine (NSC 35938) is a polypeptide that can be separated from Creatine kinase (HY-P2799), β-enolase, Triosephosphate isomerase (HY-P2931) and glyceraldehyde 3-phosphate dehydrogenase .

HY-P5012

Cbz-Glu-Gly-OH NSC 186902	Peptides	Others
Cbz-Glu-Gly-OH (NSC 186902) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4711

N-β-Alanyl-β-alanine NSC 97926	Peptides	Others
N-β-Alanyl-β-alanine (NSC 97926) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4647

Tryptophyltryptophan NSC 524592	Peptides	Others
Tryptophyltryptophan (NSC 524592) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

Cat. No.	Product Name	Target	Research Area	Image

HY-16189

Elliptinium acetate NSC 264137; Celiptium	DNA Stain	Cancer
Elliptinium acetate (NSC 264137) is a DNA intercalating agent that is highly cytotoxic to L1 210 cells and covalently binds to nucleic acids from L1210 cells. Elliptinium acetate can be used in cancer research, particularly in metastatic breast cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0488

Vincristine sulfate Maximum Cited Publications 74 Publications Verification Leurocristine sulfate; NSC-67574 sulfate; 22-Oxovincaleukoblastine sulfate	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Anti-aging Plants Disease Research Fields Alkaloid Dimers Catharanthus roseus (L.) G. Don Source Classification Cancer	Apoptosis Microtubule/Tubulin Mitosis
Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) sulfate is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-N0004

Oridonin 25+ Cited Publications NSC-250682; Isodonol	Infection Structural Classification Classification of Application Fields Terpenoids Labiatae Diterpenoids Plants Inflammation/Immunology Disease Research Fields Butea monosperma Kuntze	Akt Bacterial Ligands for E3 Ligase
Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC₅₀s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.

HY-19543

Brusatol 35+ Cited Publications NSC 172924	Structural Classification Simaroubaceae Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Brucea javanica (L.) Merr. Source Classification Cancer	Keap1-Nrf2 Apoptosis
Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent . Brusatol increases cellular apoptosis .

HY-N0142

Phloretin 20+ Cited Publications NSC 407292; RJC 02792	Classification of Application Fields Rosaceae Plants Dihydrochalcones Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms Malus pumila Mill. Phenols Polyphenols Disease Research Fields Source Classification Cancer	SGLT Endogenous Metabolite GLUT
Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill.，has anti-inflammatory activities. Phloridzin is a specific，competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC₅₀values of 49 μM and 61 μM，respectively .Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation .

HY-13764

Tetrandrine 15+ Cited Publications NSC-77037; d-Tetrandrine	Stephania tetrandra S. Moore Alkaloids Classification of Application Fields Plants Menispermaceae Inflammation/Immunology Disease Research Fields Alkaloid Dimers Source Classification	Calcium Channel Potassium Channel Parasite
Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca ²⁺ current (ICa) and Ca ²⁺-activated K ⁺ current.

HY-N0488A

Vincristine Maximum Cited Publications 74 Publications Verification Leurocristine; NSC-67574; 22-Oxovincaleukoblastine	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Plants Disease Research Fields Alkaloid Dimers Catharanthus roseus (L.) G. Don Source Classification Cancer	Apoptosis Microtubule/Tubulin Mitosis
Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-13555

β-Lapachone 10+ Cited Publications ARQ-501; NSC-26326	Quinones other families Classification of Application Fields Plants Naphthalene Quinones Disease Research Fields Source Classification Cancer	Indoleamine 2,3-Dioxygenase (IDO) Topoisomerase Autophagy Apoptosis
β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.

HY-32736

Triptonide 3 Publications Verification NSC 165677; PG 492	Classification of Application Fields Terpenoids Celastraceae Diterpenoids Tripterygium wilfordii Hook. f. Plants Inflammation/Immunology Disease Research Fields Source Classification	Wnt β-catenin Apoptosis Autophagy
Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC₅₀ of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects .

HY-17470

Mizoribine 5 Publications Verification NSC 289637; HE 69	Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	HCV SARS-CoV Antibiotic Parasite
Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-15753

Ellipticine 3 Publications Verification NSC 71795	Apocynaceae Alkaloids Classification of Application Fields Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Disease Research Fields Indole Alkaloids Source Classification Cancer	Topoisomerase
Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-79494

Glyoxalic acid (50%w/w in water) 3 Publications Verification NSC 27785; Formylformic acid; Oxalaldehydic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Endocrine diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Glyoxalic acid (NSC 27785) (50%w/w in water) is an organic compound that is both an aldehyde and a carboxylic acid. Glyoxalic acid (50%w/w in water) induces fluorescence. Glyoxalic acid (50%w/w in water) is used to study neurons . The product has a content (w/w) of 50%, meaning that the mass of Glyoxalic acid in a 250 g Size is 125 g.

HY-107850

Pregnanediol NSC 1612; NSC 47462	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Drug Metabolite UGT
Pregnanediol (NSC 1612) is a Progesterone (HY-N0437) metabolite. Pregnanediol does not affect the transcriptional activity of UGT1A1 enhancer-promoter complex of WT and variant type. pregnanediol inhibits glucuronidation activity of G71R-UGT1A1. Pregnanediol is a cause of breast milk jaundice in carriers of G71R .

HY-B0504

Creatinine 5+ Cited Publications NSC13123	Infection Structural Classification Natural Products Classification of Application Fields Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite GABA Receptor iGluR
Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure .

HY-N0837

Veratramine 1 Publications Verification NSC17821; NSC23880	Alkaloids Piperidine Alkaloids Structural Classification other families Classification of Application Fields Plants Disease Research Fields Source Classification Cancer	PI3K Akt mTOR Autophagy Apoptosis
Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a SIGMAR1 modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT)-related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy .

HY-Y1644

(E)-Crotonic acid 1 Publications Verification (E)-2-Butenoic acid; trans-2-Butenoic acid; trans-Crotonic acid	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
NSC 8751 (trans-2-Butenoic acid; trans-Crotonic acid) is an unsaturated carboxylic acid compound containing α,β-unsaturated carboxylic acid groups. NSC 8751 is one of the important analogs for evaluating the safety of fragrance ingredients and is used to evaluate the toxicological properties of compounds with similar structures. When NSC 8751 is applied to local lymph nodes, a 50% concentration does not cause skin sensitization. Structural analogs of NSC 8751 have been shown to be non-genotoxic. trans-Crotonic acid can be used in the preparation of cosmetics and food additives .

HY-N0026

2'-Acetylacteoside 1 Publications Verification 2'-AA	Structural Classification Classification of Application Fields Simple Phenylpropanols Other Diseases Scrophulariaceae Phenylpropanoids Plants Disease Research Fields Brandisia hancei Hook. f. Source Classification	Monoamine Oxidase RANKL/RANK TNF Receptor NF-κB IKK
2'-Acetylacteoside (2'-AA) is a natural compound with oral activity and blood-brain barrier permeability. 2'-Acetylacteosideexhibits MAO‑B inhibitory activity (IC₅₀ = 17.71 μM, K_i = 13.81 μM). 2'-Acetylacteoside downregulates the expression of RANK, TRAF6, NF‑κB, NFATc1 and IKKβ, disrupts the RANKL/RANK interaction, blocks downstream signaling pathways, and increases the level of phosphorylated Akt. 2'-Acetylacteoside possesses potent anti-osteoclastogenic, anti-bone resorptive, pro-neurogenic, neuroprotective and antioxidant activities. 2'-Acetylacteoside can be used in the research of osteoporosis, ischemic stroke and Parkinson's disease .

HY-N6746

Citrinin NSC 186	Infection Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Bacterial Fungal Endogenous Metabolite Apoptosis
Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-15753A

Ellipticine hydrochloride 3 Publications Verification NSC 71795 hydrochloride	Apocynaceae Alkaloids Classification of Application Fields Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Disease Research Fields Indole Alkaloids Cancer Source Classification	Topoisomerase
Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-B0751

Fumagillin 1 Publications Verification Amebacilin; NSC9168	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Parasite HIV Antibiotic
Fumagillin(NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu. Fumagillin can inhibits HIV‐1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity.

HY-N6703

ar-Turmerone (+)-ar-Turmerone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Plants Curcuma longa Inflammation/Immunology Disease Research Fields Source Classification Zingiberaceae	Apoptosis
ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study .

HY-N0863

Methyl protodioscin NSC-698790; Smilax saponin B	Structural Classification other families Classification of Application Fields Plants Disease Research Fields Steroids Source Classification Cancer	Bcl-2 Family Apoptosis Akt c-Myc ERK p38 MAPK JNK FOXO
Methyl protodioscin (NSC-698790; Smilax saponin B) is a multi-target, selective, steroidal diglycoside inhibitor with antitumor activity that induces cell cycle arrest. The mechanism of action of Methyl protodioscin is complex, involving the induction of G2/M cell cycle arrest, regulation of the Bcl-2/Bax apoptotic pathway, inhibition of the Akt1/c-Myc axis and MAPK/ERK signaling, while simultaneously downregulating ADAM15 and inducing FOXO1 to reduce cholesterol synthesis. It also inhibits the JNK/c-Jun pathway, reducing the production of inflammatory factors (IL-6, TNF-α). Methyl protodioscin exhibits significant antitumor (inhibiting proliferation, migration, invasion, and inducing apoptosis), anti-inflammatory, and anti-restenosis activities. Methyl protodioscin can be used in research on lung cancer, prostate cancer, pancreatic cancer, and other tumors, as well as inflammatory diseases such as airway inflammation and enteritis .

HY-114557

NSC 90469 3,5-Diiodo-L-thyronine	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	JNK NF-κB Sirtuin PGC-1α COX TGF-β Receptor Collagen
NSC 90469 (3,5-Diiodo-L-thyronine) is an orally active thyroid hormone derivative. NSC 90469 inhibits JNK phosphorylation and NF-κB acetylation, blocks SIRT1 protein expression, induces elevated PGC-1α levels, and stimulates COX activity. NSC 90469 enhances UCP1-mediated thermogenesis, increases hepatic Dio1 activity, inhibits TSH levels and hypothalamic-pituitary-thyroid axis function, enhances lipid metabolism, and regulates energy metabolism via the mitochondrial pathway. NSC 90469 prevents blood glucose reduction, reduces urinary albumin excretion, inhibits renal matrix expansion, decreases TGF-β1 expression, and reduces renal fibronectin and type Ⅳ collagen deposition. NSC 90469 also increases energy expenditure and prevents diet-induced overweight. NSC 90469 can be used in studies related to diabetic nephropathy, hypothyroidism, non-alcoholic fatty liver disease, and diet-induced obesity .

HY-15733

Lucidin 1 Publications Verification NSC 30546	Quinones Structural Classification Classification of Application Fields Anthraquinones Rubiaceae Phenols Polyphenols Plants Disease Research Fields Rubia cordifolia L. Source Classification Cancer	HPV Caspase Apoptosis
Lucidin (NSC 30546) is a natural component of madder and can induce mutations in bacterial and mammalian cells.

HY-B1556

Benzyl salicylate NSC 6647	Monophenols Cornaceae Classification of Application Fields Cornus walteri Wangerin Other Diseases Phenols Plants Disease Research Fields Source Classification	Environmental Pollutants Apoptosis Drug Derivative p38 MAPK ERK JNK
Benzyl salicylate (NSC 6647)?is a salicylic acid benzyl ester. It can be used as a fragrance additive or UV light absorber .

HY-Y0418

Dulcite Dulcitol; Melampyrit; NSC 1944	Structural Classification Human Gut Microbiota Metabolites Microorganisms Animals Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Saccharides Source Classification	Endogenous Metabolite
Dulcite (Dulcitol; Melampyrit; NSC 1944) is a sugar alcohol. Dulcite is produced by the reduction of galactose by aldose reductase in non-insulin-dependent cells .

HY-N4315

Pomiferin 1 Publications Verification NSC 5113	Classification of Application Fields Phenols Polyphenols Maclura pomifera (Raf.) Schneid. Plants Moraceae Disease Research Fields Cancer Source Classification	HDAC mTOR
Pomiferin (NSC 5113) acts as an potential inhibitor of HDAC, with an IC₅₀ of 1.05 μM, and also potently inhibits mTOR (IC₅₀, 6.2 µM).

HY-118384

Sangivamycin 3 Publications Verification NSC 65346; BA-90912	Natural Products Microorganisms Classification of Application Fields Disease Research Fields Cancer Source Classification	PKC Nucleoside Antimetabolite/Analog
Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an K_i of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers .

HY-101413

Iberin 2 Publications Verification NSC 321801	Natural Products other families Classification of Application Fields Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Apoptosis Endogenous Metabolite Bacterial
Iberin (NSC 321801), a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. Iberin inhibits cell survival with an IC₅₀ of 2.3 μM in HL60 cell. Iberin induces apoptosis.

HY-Y0760

3-Methoxybenzoic acid 3-Anisic acid; NSC 27014; m-Methoxybenzoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate
3-Methoxybenzoic acid (3-Anisic acid; NSC 27014; m-Methoxybenzoic acid) is a substituted benzoic acid and precursor for synthesis of hydrazide-hydrazone derivatives active against Gram-positive bacteria, including Bacillus spp .

HY-N1393

2-Methoxybenzoic acid NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Carbonic Anhydrase Phospholipase
2-Methoxybenzoic acid (NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether) is a natural compound with potential salicylate-like effect. 2-Methoxybenzoic acid inhibits carbonic anhydrase activity, elevates intraplatelet cyclic guanosine monophosphate level, and suppresses cytosolic phospholipase A₂ phosphorylation. 2-Methoxybenzoic acid suppresses platelet reactivity, including decreased spreading, retraction, and aggregation in platelets. 2-Methoxybenzoic acid ameliorates arterial thrombosis in a dose-dependent manner without affecting normal hemostasis in mice. 2-Methoxybenzoic acid can be used for the research of arterial thrombosis .

HY-B0504R

Creatinine (Standard) NSC13123 (Standard)	Infection Structural Classification Natural Products Microorganisms Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite iGluR GABA Receptor
Creatinine (Standard) is the analytical standard of Creatinine. This product is intended for research and analytical applications. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure .

HY-B1476

NSC 42196	Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Source Classification	Endogenous Metabolite
NSC 42196 is an endogenous metabolite.

HY-Y0124

NSC 16590 α,α-Dimethylglycine; α-Aminoisobutanoic acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Pterocarpus soyauxii Taub. Other Diseases Plants Compositae Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
NSC 16590 inhibits the production of endogenous ethylene in the cotyledonary segments of cocklebur.

HY-118166

Gentisein NSC 329491; 1,3,7-Trihydroxyxanthone	other families Xanthones Classification of Application Fields Neurological Disease Phenols Polyphenols Plants Disease Research Fields Source Classification	5-HT Receptor
Gentisein (NSC 329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC₅₀ value of 4.7 µM .

HY-B1777R

Spermine (Standard) NSC 268508 (Standard); Neuridine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Influenza Virus
Spermine (Standard) is the analytical standard of Spermine. This product is intended for research and analytical applications. Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects.

HY-34439

2,5-Dimethylpyrazine NSC 49139	Structural Classification Natural Products Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
2,5-Dimethylpyrazine (NSC 49139) is an endogenous metabolite. 2,5-Dimethylpyrazine in produced in food systems of two whey protein hydrolysates, obtained using either trypsin or proteinase from Aspergillus melleus. 2,5-Dimethylpyrazine can be qualitatively monitored using a stable isotope dilution assay. 2,5-Dimethylpyrazine can also be generated via microbial mechanisms using Bacillus subtilis. 2,5-Dimethylpyrazine can be oxidized to form 5-methylpyrazine-2-carboxylic acid, which is the intermediate in the synthesis of antilipoltic agent. 2,5-Dimethylpyrazine is a volatile compound that can give a roasted peanut flavor .

HY-114502

Chrysanthemic acid NSC 11779	Ketones, Aldehydes, Acids Plants Compositae Phaseolus lunatus Billb. ex Beurl. Source Classification	Insecticide
Chrysanthemic acid (NSC 11779) is an organic compound that is associated with a variety of natural and synthetic insecticides for the prevention of insect-borne diseases, among others .

HY-N1375

Qingyangshengenin	Monophenols Classification of Application Fields Asclepiadaceae Phenols Cynanchum otophyllum Schneid． Plants Disease Research Fields Steroids Cancer Source Classification	Others
Qingyanshengenin (NSC 379666; compound 2), a pregnane glycoside, is a C21 steroidal aglycone isolated from the root of Cynanchumot ophyllum (Asclepiadaceae). Qingyanshengenin has anti-cancer activity .

HY-Y0057

NSC 13138 Cinchoninic acid (6CI,7CI,8CI); 4-Carboxyquinoline	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
NSC 13138 is an endogenous metabolite.

HY-N0837R

Veratramine (Standard) NSC17821 (Standard); NSC23880 (Standard)	Alkaloids Piperidine Alkaloids Structural Classification other families Plants Source Classification	Reference Standards PI3K Akt mTOR Autophagy Apoptosis
Veratramine (NSC17821; NSC23880) (Standard) is the analytical standard of Veratramine (HY-N0837). This product is intended for research and analytical applications. Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a SIGMAR1 modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT)-related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy .

HY-W047478

3-Methylcarbazole NSC 10154	Alkaloids Structural Classification other families Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Source Classification Cancer	Fungal Interleukin Related
3-Methylcarbazole (NSC 10154) is a carbazole alkaloid with an IC₅₀ of 25 μg/mL against human fibrosarcoma cells. 3-Methylcarbazole inhibits mycelial growth and conidial germination of a variety of phytopathogenic fungi. 3-Methylcarbazole exhibits anti-inflammatory and antitumor activities. 3-Methylcarbazole can be used in studies related to fibrosarcoma, phytopathogenic fungal infections and inflammatory diseases .

HY-134000

Emodic acid NSC624610	Quinones Human Gut Microbiota Metabolites Microorganisms Leguminosae Cercis chinensis Bunge Anthraquinones Plants Endogenous metabolite Source Classification	p38 MAPK NF-κB ERK JNK VEGFR MMP
Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells .

HY-17470R

Mizoribine (Standard) NSC 289637 (Standard); HE 69 (Standard)	Alkaloids Structural Classification Microorganisms Other Alkaloids Source Classification	Reference Standards HCV SARS-CoV Antibiotic Parasite
Mizoribine (Standard) is the analytical standard of Mizoribine. This product is intended for research and analytical applications. Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-N3655

Cyclo(D-Phe-L-Pro) NSC 255998	Alkaloids Microorganisms Other Alkaloids Source Classification	Others
Cyclo(D-Phe-L-Pro) (NSC 255998) is a flavonoid product that can be isolated from Rhododendron mucronulatum .

HY-N3272

Methyl levulinate Methyl β-acetylpropionate; NSC 24874	Apocynaceae Natural Products Rauvolfia vomitoria Afzel. Plants Source Classification	Others
Methyl levulinate (NSC 24874) is a Alkaloids product that can be isolated from the stems and leaves of Ervatamia hainanensis. .

HY-N10687

Saprorthoquinone NSC 648341	Quinones Labiatae Plants Naphthalene Quinones Source Classification Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Others
Saprorthoquinone (NSC 648341) is a diterpenoid that can be found in salvia atropatana. Saprorthoquinone shows cytotoxicity for PC3 cells .

HY-105529

Indicine N-oxide (+)-Indicine N-oxide; NSC 132319	Alkaloids Pyrrole Alkaloids Classification of Application Fields Tournefortia argentea Linnaeus f. Plants Boraginaceae Disease Research Fields Source Classification Cancer	Microtubule/Tubulin
Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research .

HY-114772

Methyl reserpate NSC 81464; Me reserpate	Apocynaceae Alkaloids Other Alkaloids Rauvolfia vomitoria Afzel. Plants Source Classification	Others
Methyl reserpate (NSC 81464) is a Yohimbine (HY-12715) type alkaloid that can be isolated from Rauwolfia vomitoria roots and leaves .

HY-105697

Protoveratrine A NSC 7526; Protalba; Protoveratrin	Alkaloids Piperidine Alkaloids Veratrum nigrum Linn. Liliaceae Plants Source Classification	Glutamate Dehydrogenase (GLDH)
Protoveratrine A (NSC 7526; Protalba; Protoveratrin) is an alkaloid with strong cardiostimulant and vasoconstrictive effects, which can be used in the study of hypertension and other cardiovascular diseases .

HY-B0751R

Fumagillin (Standard) Amebacilin (Standard); NSC9168 (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Parasite HIV Antibiotic
Fumagillin (Standard) is the analytical standard of Fumagillin. This product is intended for research and analytical applications. Fumagillin(NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu. Fumagillin can inhibits HIV‐1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity.

Cat. No.	Product Name	Chemical Structure

HY-B0504S

Creatinine-d3

5 Publications Verification

Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure .

HY-B0504S2

Creatinine-d5

Creatinine-d₅ is the deuterium labeled Creatinine. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure .

HY-15036S

Diclofenac-d4
Diclofenac-d₄ is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-W050026S

Phenylacetylglutamine-d5 2 Publications Verification
Phenylacetylglutamine-d₅ (NSC 203800-d₅) is the deuterium labeled Phenylacetylglutamine (HY-W050026). Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation .

HY-W654342

Spermine-d20
Spermine-d₂₀ (NSC 268508-d₂₀) is deuterium labeled Spermine. Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects .

HY-14655S

Sulfasalazine-d4
Sulfasalazine-d₄ is the deuterium labeled Sulfasalazine. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .

HY-17364S

Temozolomide-d3

Temozolomide-d₃ is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .

HY-B0504S1

Creatinine-13C

Creatinine- ¹³C is the ¹³C-labeled Creatinine. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure .

HY-Y0124S

NSC 16590-d6
NSC 16590-d₆ is the deuterium labeled NSC 16590. NSC 16590 inhibits the production of endogenous ethylene in the cotyledonary segments of cocklebur.

HY-B1556S

Benzyl salicylate-d4
Benzyl salicylate-d₄ (NSC 6647-d₄) is the deuterium labeled Benzyl salicylate (HY-B1556). Benzyl salicylate (NSC 6647)?is a salicylic acid benzyl ester. It can be used as a fragrance additive or UV light absorber .

HY-123533S

Resorufin-d6
Resorufin-d₆ is the deuterium labeled Resorufin. Resorufin (NSC 12097) is a highly fluorescent pink dye for the detection of ROS/RNS and a second analyte .

HY-W779017

Thymidine-13C5
Thymidine- ¹³C₅ (DThyd- ¹³C₅; NSC 21548- ¹³C₅) is ¹³C-labeled Thymidine (HY-N1150) .

HY-N1150S11

Thymidine-13C10
Thymidine- ¹³C₁₀ (DThyd- ¹³C₁₀; NSC 21548- ¹³C₁₀) is ¹³C-labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.

HY-15036S1

Diclofenac-13C6
Diclofenac- ¹³C₆ is the ¹³C₆ labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-17393S

Carboplatin-d4
Carboplatin-d₄ is the deuterium labeled Carboplatin. Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.

HY-N5034S

Phosphorylethanolamine-d4
Phosphorylethanolamine-d₄ (Monoaminoethyl phosphate-d₄; NSC 254167-d₄) is a deuterium labeled Phosphorylethanolamine (HY-N5034). Phosphorylethanolamine is an endogenous metabolite.

HY-B0246S3

Carbamazepine-(Ph)d8
Carbamazepine-(Ph)d8 (CBZ-(Ph)d8; NSC 169864-(Ph)d8) is the deuterium labeled Carbamazepine-(Ph) (HY-B0246) .

HY-B0139S

Flucytosine-13C,15N2
Flucytosine- ¹³C, ¹⁵N₂ (NSC 103805- ¹³C, ¹⁵N₂; Ro 2-9915- ¹³C, ¹⁵N₂) is a ¹³C- and ¹⁵N-labeled Flucytosine (HY-B0139).

HY-N0488S

Vincristine-d3 sulfate

Vincristine-d₃ sulfate is the deuterium labeled Vincristine sulfate. Vincristine sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-B0504S5

Creatinine-15N

Creatinine- ¹⁵N (NSC13123- ¹⁵N) is the ¹⁵N-labeled Creatinine (HY-B0504). Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure .

HY-15037S2

Diclofenac-13C6 sodium

Diclofenac- ¹³C₆ (Sodium) is the ¹³C₆ labeled Diclofenac (Sodium). Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-15037S1

Diclofenac-d4 sodium

Diclofenac-d₄ (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-W747491

Triclosan-13C12

Triclosan- ¹³C₁₂ is ¹³C labeled Triclosan (HY-B1119). Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC₅₀s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .

HY-Y0219S1

1,2,4-Triazole-d3
NSC 83128-d₃ is the deuterium labeled NSC 83128 .

HY-W654270A

(rac)-Calcium N5-methyltetrahydrofolate-d3
(rac)-Calcium N5-methyltetrahydrofolate-d₃ ((rac)-NSC173328-d₃) is a deuterium labeled (rac)-Calcium N5-methyltetrahydrofolate.

HY-N1150S10

Thymidine-d14
Thymidine-d₁₄ (DThyd-d₁₄; NSC 21548-d₁₄) is deuterium labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.

HY-13768S1

Topotecan-d6
Topotecan-d₆ is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC₅₀ values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95 μM of GSCs-U87 .

HY-W653962

Triclosan-13C6

Triclosan- ¹³C₆ is ¹³C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC₅₀s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .

HY-Y1675S

NSC 65593-d4
NSC 65593-d₄ is the deuterium labeled NSC 65593 .

HY-N0055S

Chlorogenic acid-13C3

Chlorogenic acid- ¹³C₃ (Heriguard- ¹³C₃; NSC-407296- ¹³C₃) is ¹³C- and ¹⁵N-labeled Chlorogenic acid (HY-N0055). Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb.. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension .

HY-N0488S2

Vincristine-d6 sulfate

Vincristine-d₆ (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-N0488S1

Vincristine-d3-1 sulfate

Vincristine-d₃ sulfate is the deuterium labeled Vincristine sulfate. Vincristine-1 sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine-1 sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine-1 sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine-1 sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-10211S

Tanespimycin-d5

Tanespimycin-d₅ (17-AAG-d₅; NSC 330507-d₅; CP 127374-d₅) is the deuterium labeled Tanespimycin (HY-10211). Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC₅₀ of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90 . Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression .

HY-B1777S

Spermine-15N2

Spermine- ¹⁵N₂ (NSC 268508- ¹⁵N₂) is the ¹⁵N-labeled Spermine (HY-B1777). Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro .

HY-Y1630S

NSC 10281-d4
NSC 10281-d₄ is the deuterium labeled NSC 10281 .

HY-Y0251S

3-Nitrophthalic acid-d3
NSC 3120-d₃ is the deuterium labeled NSC 3120 .

HY-52155S

NSC 89275-d12
NSC 89275-d₁₂ is the deuterium labeled NSC 89275 .

HY-W704348

Diphenyltin Dichloride-d10
Diphenyltin Dichloride-d₁₀ is the deuterium labeled NSC405640 (HY-144105). NSC405640 is a potent inhibitor of the MDM2-p53 interaction. NSC405640 rescues structural p53 mutations. NSC405640 selectively inhibits the growth of cell lines with wild-type p53 .

HY-Y0219S

1,2,4-Triazole-13C2,15N3
NSC 83128- ¹³C₂, ¹⁵N₃ is the ¹³C and ¹⁵N labeled NSC 83128 .

HY-W699526

Dimebutic acid-d6

Dimebutic acid-d₆ (NSC-16045-d₆; NSC-741804-d₆) is the deuterium labeled Dimebutic acid (HY-W015881). Dimebutic acid is a fatty acid derivative. Dimebutic acid is an orally active short-chain fatty acid. Dimebutic acid stimulates fetal globin production and alters the balance of Bcl family proteins. Dimebutic acid prolongs red blood cell survival. Dimebutic acid exhibits toxicity in rats. Dimebutic acid is used in the study of β-thalassemia and sickle cell disease .

HY-W022039S

(Benzyloxy)benzene-d2
(Benzyloxy)benzene-d2 (NSC 77971-d2) is the deuterium labeled Benzyloxybenzene (HY-W022039) .

HY-W701362

Glurate-d5

Glurate-d₅ (4-Acetylbutyric acid-d₅; 5-Oxohexanoic acid-d₅; NSC-5281-d₅) is the deuterium labeled Glurate (HY-W001957). Glurate (4-Acetylbutyric acid) is an acylating agent. Glurate can be used in the development of antiviral compounds, especially those targeting retroviruses such as herpes virus and HIV. Glurate can be used in the synthesis of acyclic nucleoside derivatives and 5-hydroxyhexanoic acid .

HY-W727919

2-Carbamoylbenzoic acid-d4
2-Carbamoylbenzoic acid-d₄ (NSC 5344-d₄; Phthalamide acid-d₄; Phthalamidic acid-d₄) is the deuterium labeled 2-Carbamoylbenzoic acid (HY-111196).

HY-N6746S1

Citrinin-13C13

Citrinin- ¹³C₁₃ (NSC 186- ¹³C₁₃) is the ¹³C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-W777033

Tegafur-13C,15N2
Tegafur- ¹³C, ¹⁵N₂ (FT 207- ¹³C, ¹⁵N₂) is the ¹³C- and ¹⁵N-labeled Tegafur (HY-17400). Tegafur (FT 207; NSC 148958) is a chemotherapeutic 5-FU proagent used in the treatment of cancers; is a component of tegafur-uracil.

HY-14655S1

Sulfasalazine-d3,15N
Sulfasalazine-d₃, ¹⁵N is ¹⁵N and deuterated labeled Sulfasalazine (HY-14655). Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .

HY-Y0484S

1-Indanamine-d9 hydrochloride
1-Indanamine-d₉ (1-Aminoindan-d₉; 1-Aminoindane-d₉; NSC 186227-d₉; 1-Aminoindane-d₉) hydrochloride is deuterium-labeled 1-Indanamine hydrochloride (HY-Y0484) .

HY-Y1217S

1-Cyclohexanol-d12
1-Cyclohexanol₁₂ (Hydroxycyclohexane₁₂; NSC 54711₁₂) is the deuterium labeled 1-Cyclohexanol (HY-Y1217). 1-Cyclohexanol is an orally active Cramer Class I flavor ingredient that can be used in fragrances. 1-Cyclohexanol has a wide margin of safety and is environmentally friendly.

HY-W751834

6-Amino-5-nitropyrimidine-2,4(1H,3H)-dione-13C3
6-Amino-5-nitropyrimidine-2,4(1H,3H)-dione- ¹³C₃ (NSC 99321- ¹³C₃) is the ¹³C-labeled 6-Amino-5-nitropyrimidine-2,4(1H,3H)-dione (HY-W016913).

HY-W778920

5α-Cholestan-3β-ol-d7
5α-Cholestan-3β-ol-d₇ (Dihydrocholesterol-d₇; 5α-Cholestanol-d₇; NSC 18188-d₇) is the deuterium labeled 5α-Cholestan-3β-ol (HY-107819). 5α-Cholestan-3β-ol is a derivitized steroid compound.

Cat. No.	Product Name		Classification

HY-131818

5'-Amino-5'-deoxyadenosine NH2dAdo; Nsc 238990		Nucleoside Analogs Adenosine
5'-Amino-5'-deoxyadenosine (NH2dAdo; Nsc 238990) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-W130466

N4-Methylcytidine		Nucleoside Analogs Cytidine
N4-Methylcytidine (Nsc518744) is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

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